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Pharmacology III > Gout > Flashcards

Gout Flashcards

1
Q

Indomethacin and Colchicine are used for _________ management of Gout

A

acute

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2
Q

probenecid, allopurinol, febuxostat, rasburicase and prgloticase are used for ___________ of gout

A

chronic prevention

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3
Q

Other than indomethacin, which NSAID can be used for acute gout flares?

A

naproxen

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4
Q

Which NSAIDs are C/I for gout and why?

A

ASA/Salicylates

acidic = decreased urate excretion via OAT-2 competition

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5
Q

Does colchicine has analgesic effects?

A

no

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6
Q

Mechanism of action for colchicine?

A

binds tubulin and inhibits leukocyte migration and phagocytosis

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7
Q

How long for colchicine to take effect?

A

12-24 hours

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8
Q

major adverse effect of colchicine?

A

diarrhea

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9
Q

Which drugs for gout are uricosuric agents?

A

probenecid

lesinurad

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10
Q

Uricosuric agents have what mechanism?

A

block active reabsorption of uric acid in PCT

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11
Q

uricosuric agents must be administered with adequate hydration due to this potential SE

A

stone formation

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12
Q

Urine pH must be above _______ when administering uricosuric agents…

A

6.0

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13
Q

major SE of uricosuric agents?

A

GI irritation

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14
Q

Which uricosuric agent?

decrease excretion of many acidic compounds or metabolites like PCN

PO admin

A

probenecid

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15
Q

When should probenecid be started?

A

2-3 weeks after acute attack

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16
Q

Which uricosuric agent?

URAT1 inhibitor

combine with XOI

A

lesinurad

17
Q

this class is effective in both primary and secondary gout.

initial therapy may provoke gouty attack

administer with colchicine prophylaxis

A

XOIs (allopurinol, febuxostat)

18
Q

Mechanism of allopurinol and febuxostat…

A

inhibit uric acid synth via xanthine oxidase inhibition

19
Q

SEs of allopurinol and febuxostat? (3)

A

vasculitis
agranulocytosis
hypersensitivity

20
Q

aluminum hydroxide _______ the absorption of allopurinol

A

decreases

21
Q

Allopurinol increases the effects of which three drugs?

A

Mercaptopurines (6MP, azathioprine)

Cyclphosphamide

22
Q

Allpurinol inhibits the elimination of…

A

chlorpropamide

23
Q

Allopruinol inhibits metabolism of which 2 drugs?

A

warfarin and probenecid

24
Q

Allopurinol inhibits the activation of…

A

5FU

25
Q

This is a recombinant form of urate oxidase, which isn’t present in humans.

A

Rasburicase

26
Q

Rasburicase catalyzes oxidation of uric acid to ________, which has what effect?

A

uric acid to allantoin, readily excreted

27
Q

Major SE of rasburicase…

A

anaphylaxis

28
Q

rasburicase can be used for those at risk of…

A

TLS

29
Q

“Me too” drug of rasburicase…

recombinant mammalian urate oxidase

A

pegloticase

30
Q

This drug is a URAT 1 inhibitor, which decreases the reabsorption of uric acid

A

lesinurad

31
Q

Lesinurad has a warning on acute renal failure… this is more common when administered how?

A

monotherapy, higher doses

32
Q

What should lesinurad be combined with?

A

XOI

Pharmacology III (15 decks)

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