Mieloma Multiple Flashcards

1
Q

Edad media del mieloma multiple

A

68 años

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2
Q

Sintoma mas comun

A

Dolor oseo 70% por la destruccion del hueso

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3
Q

Causa mas frecuente de I renal en MM

A

Excrecion de cadenas ligeras o proteinuria de Bence Jones

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4
Q

Que es el MM

A

Acumulacion de celulas plasmaticas o linfos B en MO

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5
Q

Laboratorial mas frecuente

A

Hipercalcemia

VSG elevada

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6
Q

Dx para MM

A
Componente M serigo >30- gold standar 
Prtoteina M en orina 
Plasmocitoma
>10% de celulas plasmaticas en MO 
LESIONES osteoliticas
CA elevado
Anemia normo normo
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7
Q

Mieloma por iGM uq eprovoca

A

Hiperviscosidad

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8
Q

Indicadores de estadiaje

A

B 2 microglobulina

Albumina

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9
Q

Tto de eleccion en < 65 años

A

Transpalnte autologo

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10
Q

Tto >65 años sintomaticos con MM

A

Melfalan + Talidomida+ prednisona

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11
Q

Inmunoglobulina mas comun en elevarse en MM

A

Ig G

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12
Q

Inmunoglobulina producida en la enfermedad de Waldenstrom

A

IgM - provoca hiperviscosidad y su tto es plasmaferesis

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13
Q

Diferencia de la enfermedad de Walndenstrom con MM

A

No hay lesion renal ni lesiones osteoliticas

Si hay adenopatias, esplenomegalia y purputa

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14
Q

Criterios de una gamapatia Monoclonal con significado incierto

A
Proteinuria de Bence Jones minima 
Plasmocitosis en MO > 10 %
IgG <3 
Ig A <2
Puede evolucionar a MM
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15
Q

Ennfermedades que se puede realizar un transplante autologo

A

MM
LINFOMA
Neuroblastoma

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16
Q

ENfermedades en que se realiza un transplante alogenico

A

Leucemia
Anemia aplasica severa
Talasemias

17
Q

Que es el sindrome de lisis tumoral

A
Hiperuricemia
Hiperfosfatemia
Hiperpotasemia
Hipocalcemia 
Falla renal