Midterm Flashcards
blood supply to the brain
ICA
Vertebral A
Circle of Willis Arteries
Anterior communicating A Anterior Cerebral A Middle Cerebral A Posterior Cerebral A ICA Posterior Communicating A Vertebrobasilar
***Aneurysm
Ant. Communicating
Stroke
Lat. Striate of MCA
Dura layers
2 cranial
1 spinal
Arachnoid
No blood vessels
Spinal cord blood supply
2/3 Ant. Spinal A
1/3 Post. Spinal A
Subarachnoid contents
CSF
Subdural contents
bridging veins
***Epidural hematoma
Middle Meningeal A
- lucid interval
- lens shaped
Subdural Hematoma
no trauma/elderly
crescent shaped
(hyperdense=white/acute)
(hypodense=dark/old)
***Subarachnoid Hemorrhage
aneurysm leakage
“worst headache of life”
blood stained CSF
—Intracranial/Intracerebral Hemorrhage
lenticulostriate of MCA
loses consciousness
paralysis upon awakening
emissary veins
valveless
choroid plexus
produces CSF
formed by ependymal cells
***CSF circulation
Lateral ventricles - foramen of monro Third Ventricle - aqueduct of sylvius Fourth Ventricle - foramen of luschka (lat.) - foramen of magendie (med) Subarachnoid space -> recirculation
lumbar puncture
L4/L5
Non-communicating Hydrocephalus
obstruction within ventricles
(ex. aqueductal stenosis)
enlarged head
—Communicating Hydrocephalus
blockage in subarachnoid space
no reabsorption
—Findings: arachnoid granulation
Normal Pressure Hydrocephalus
(communicatiing)
WACKY
WOBBLY
WET
***Bacterial Meningitis
CLOUDY CSF increased WBC DECREASED GLUCOSE increased protein increased pressure
headache, fever, neck rigidity
Viral encephalitis
clear or cloudy CSF
slightly elevated protein
normal glucase
soma
nucleus
cytoplasm
NISSL BODIES
dendrites
impulses TOWARDS cell body
proximal = NISSL distal = NO NISSL
Axon Hillock
NO NISSL
Action Potential arises here
Multipolar neurons
motor
many processes
from soma
Golgi type 1
long
Golgi type 2
short
glial cells in PNS
Schwann cells
Myelination
increases conductance
decreases energy expense
protection
fast anterograde
KINESIN
fast retrograde
DYNEIN neurotropic viruses (ex. herpes)
Neuropraxia
1st degree
transient block
full recovery
Axonotemesis
Axon damaged, but sheath intact
WALLERIAN DEGENERATION
functional recovery
Neurotemesis
5th degree
complete section of the nerve trunk
***wallerian degeneration
distal to the site of damage on the axon
chromatolysis
cell body swells (edema)
nucleus shifts peripherally
Nerve regeneration location
PNS ONLY
Axodendritic synapse
80% cerebral cortex
Axosomatic synapse
15% cerebral cortex
chemical synapse
one way
slow
electrical synapse
bi-directional
fast
smooth & cardiac muscle
small clear vesicles
Ach
GABA
glycine
glutamate
small dense core vesicles
catecholamines
large dense core vesicles
neuropeptide
T-SNARE
SNAP25, Syntaxin
on Terminal membrane
V-SNARE
Synaptotagmin, Synaptobrevin
on synaptic vesicle
Excitatory Post-synaptic
depol.
ACh, Nor-adrenaline
Inhibitory Post-synaptic
hyperpol.
GABA, Glycine
***Peripheral synapse
nAChR (only excitatory)
***Myesthenia Gravis
nAChR at NMJ
increased anti-MuSK Ab
thymoma
***Lambert Eaton
Ca channels at pre-synaptic terminal
SCLC
***Botulism
cleaves SNARE at pre-synaptic membrane
Infantile Botulism
associated with honey
type A&B
Wound Botulism
associated with black tar heroin
Tetanus
protease cleaves SNARE proteins muscle hyperexcitation (tetanic contractions)
neurotransmitter vs neuromodulator
neurotransmitter
elicits specific response
neuromodulator
not directly cause EPSP or IPSP
excitatory receptor
NMDA
inhibitory receptor
GABA
degradation of neurotransmitter
acetylcholinesterase
ionotropic receptor
ligand gated
metabotropic receptor
GCPR
basal plate
anterior/ventral horn
motor
alar plate
posterior/dorsal horn
sensory
Procencephalon
telencephalon -> cerebral hemispheres
diencephalon -> thal., hypothal., subthal., neuropit.
Mesencephalon
mibrain
Rhombencephalon
Metencephalon -> pons, cerebellum
Myencephalon -> medulla
cyst adjoining choroid plexus
roof plate
decreased CSF
Anencephaly
anterior/rostal neuropore
partial/complete absence of brain
Encephalocele
portions of anterior neuropore
sac-like protrusion
mental retardation
holoprosencephaly
failure of midline cleavage
seen in fetal alcohol & Patau
microcephaly
less than third percentile
Spina bifida
posterior/caudal neuropore
Spina bifida occulta
defect in vertebral arches
tuft of hair
Spina bifida cystica
dysraphism