MIDTERM Flashcards
The study of structural and functional manifestations of disease
Pathology
The study of disease that can cause abnormalities in the structure or function of various organ systems.
PATHOLOGY
Branch of the study disease causes, where it was, development and effect on the body.
PATHOLOGY
examine the dead body, under part of the pathology
autopsy
BRANCHES OF PATHOLOGY: where examine tissue sample, example covid and biopsy
ANATOMICAL PATHOLOGY
4 BRANCHES OF PATHOLOGY:
ANATOMICAL PATHOLOGY
CLINICAL PATHOLOGY
FORENSIC PATHOLOGY
MOLECULAR PATHOLOGY
disrupt of body and brain, not normal functioning
Disease
BRANCHES OF PATHOLOGY: where examine bodily fluids
CLINICAL PATHOLOGY
certain types of disease:
- Infection
- Acute diseaes - example: saglit lang pero malala, heart attack, stroke, diabetes, autoimmune disease
- Genetic disease
- Metabolic disease
BRANCHES OF PATHOLOGY: where dead body, cause of death, use for legal purposes
FORENSIC PATHOLOGY
BRANCHES OF PATHOLOGY: study of molecular level example: pregnant find abnormality of baby the gender of the baby
MOLECULAR PATHOLOGY
what extract fluid that causes of fluid in lungs
THORACENTESIS
Study of various pathologic conditions and its effect on radiologic procedures, techniques and overall radiographic image.
RADIOLOGIC PATHOLOGY
are often known to be medical conditions that are associated with specific symptoms and signs.
DISEASE
observable changes
PATHOGENESIS
is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not due to any immediate external injury.
DISEASE
The sequence of events producing cellular changes that ultimately lead to observable changes.
PATHOGENESIS
Is any objective evidence of a disease that can be observed by others (for example a skin rash or lump)
SIGN
Is subjective, that is, apparent only to the patient (for example back pain or fatigue)
SYMPTOM
Observable changes resulting from cellular changes in the disease process.
MANIFESTATIONS
the study of the cause of a disease
ETIOLOGY
A group of sign and symptoms that characterizes a specific abnormal disturbance.
SYNDROME
Means there are no symptoms
ASYMPTOMATIC
Combination, cause of chromosome, physical features and lack development
SYNDROME
Which has been acquired while the patient is in hospital.
NOSOCOMIAL INFECTION
Those adverse responses that occur from medical treatment itself.
example : chemotherapy
IATROGENIC REACTIONS
The prediction of the course and outcome of the disease
prognosis
Usually have a quick onset and last a short period of time.
ACUTE DISEASES
Describe disease of unknown cause.
Rare disease
IDIOPATHIC
Present more slowly and last a very long time.
CHRONIC DISEASES
Determination of the diseases than an individual has.
DIAGNOSIS
shrinking of lungs
COPD
The investigation of disease in large group
Example : MPOX or covid
EPIDEMIOLOGY
A disease which simultaneously affects large numbers of people in a community
EPIDEMIC
The number of cases found in a given population
PREVALANCE
The number of new cases found in given population
INCIDENCE
Disease of high prevalence in an area where a given causative organism
ENDEMIC
Ratio of actual deaths to expected death from a given disease
MORTALITY RATE
The rate of deaths caused by a particular disease averaged over a population
MORTALITY RATE
DISEASES CLASSIFICATIONS
CONGENITAL DISEASE
HEREDITARY DISEASE
INFLAMMATORY DISEASE
DEGENERATIVE DISEASE
METABOLIC DISEASE
TRAUMATIC DISEASE
NEOPLASTIC DISEASE
Diseases that are present at birth and result from genetic or environmental factors.
CONGENITAL DISEASE
also known as a congenital disorder, is a condition present at birth regardless of its cause. It may result in disabilities that may be physical, intellectual, or developmental.
Birth defects
Most birth defects are caused by
genetic or environmental factors or a combination of the two (multifactorial birth defects). In most cases, however, the cause is unknown.
3 reasons of congenital disease:
Genetics
Environmental factor
Combination of two the genetics and environmental factor - multifactorial
An environmental cause can include a drug, alcohol or a disease the mother has that can increase the chance for the baby to be born with a birth defect. An agent that can cause a birth defect is known as a
teratogen.
Common congenital disorders:
cleft lip and cleft palate
cerebral palsy
Fragile X syndrome
Down syndrome
spina bifida
cystic fibrosis
heart conditions
cause can include a drug, alcohol or a disease the mother has that can increase the chance for the baby to be born with a birth defect.
environmental
Genetic or inherited causes include:
- Chromosomal defects caused by too few or too many chromosomes, or problems in the structure of the chromosomes, such as Down syndrome and extra copy of chromosome 21 and sex chromosome abnormalities
- Single gene defects
- Dominant inheritance
- Recessive inheritance
The chromosomes in the humans are responsible for passing the traits from the parent to the offspring.
Example: alzheimer’s disease or asthma
. HEREDITARY DISEASE
It is a disease or disorder that is inherited genetically.
. HEREDITARY DISEASE
are caused by a combination of genes and environmental exposures. In other words, a person can inherit a gene that increases sensitivity to an environmental trigger. Examples include cleft lip or palate, certain heart defects, and neural tube defects.
Multifactorial birth defects
in CLASSIFICATION of hereditary disease: Transmitted by a single gene from either parent chromosomes
DOMINANT INHERITANCE
are passed on from one generation to another through defective genes
. HEREDITARY DISEASE
CLASSIFICATION of hereditary disease:
- SEX-LINKED -A genetic abnormality present on the sex chromosome
- AUTOSOMAL INHERITANCE- A genetic abnormality present on one of the other 22 chromosomes
- DOMINANT INHERITANCE -Transmitted by a single gene from either parent chromosomes
- RECESSIVE INHERITANCE -Transmitted by both parents to an offspring
in CLASSIFICATION of hereditary disease: Transmitted by both parents to an offspring
RECESSIVE INHERITANCE
in CLASSIFICATION of hereditary disease: A genetic abnormality present on the sex chromosome
SEX-LINKED
These diseases are transmitted in the same family.
. HEREDITARY DISEASE
is a hereditary disease caused by mutations in one of the genes that encode the hemoglobin protein. Red blood cells with the abnormal hemoglobin protein take on a sickle shape. The disease leads to chronic anemia and significant damage to the heart, lungs and kidneys.
Sickle cell disease
is caused by a gene mutation that affects the cells that produce mucus, sweat, and digestive juices. The mucus becomes thick and sticky, causing severe damage to the respiratory, digestive and reproductive systems.
Cystic fibrosis (CF)
in CLASSIFICATION of hereditary disease: A genetic abnormality present on one of the other 22 chromosomes
AUTOSOMAL INHERITANCE
Multifactorial birth defects are caused by a combination of genes and environmental exposures. In other words, a person can inherit a gene that increases sensitivity to an environmental trigger. Examples include
cleft lip or palate, certain heart defects, and neural tube defects.
6 COMMON HEREDITARY DISEASES
- SICKLE CELL DISEASES
- CYSTIC FIBROSIS
- TAY-SACHS
- HEMOPHILIA
- HUNTINGTON’S DISEASE
- MUSCULAR DYSTROPHY
tay sachs disease another term
Destroy nervous system or bench double
Children who inherit only one copy of the defective gene are carriers who could pass the gene on to their own children. But children who inherit two copies of the defective gene one copy from each parent will develop
cystic fibrosis
Is a well-known hereditary disease in which proper clotting is absent.
HEMOPHILIA
Tay-Sachs disease (TSD) is a fatal genetic disorder that results in progressive destruction of the nervous system. It is caused by gene defects that lead to the absence of a vital enzyme called
hexosaminidase-A (Hex-A).
what disease Destroy nervous system or bench double
Tay-Sachs disease (TSD)
is a fatal genetic disorder that results in progressive destruction of the nervous system. It is caused by gene defects that lead to the absence of a vital enzyme called hexosaminidase-A (Hex-A).
Tay-Sachs disease (TSD)
INFLAMMATORY DISEASE
Results from the body’ reaction to a localized injurious agent.
Examples include
allergy, asthma, autoimmune diseases, coeliac disease, glomerulonephritis, hepatitis, inflammatory bowel disease, preperfusion injury and transplant rejection.
defective genes interfere with the production of proteins necessary for healthy muscle development. Such symptoms as progressive muscle weakness and loss of muscle mass often begin in childhood, though the disease can affect all ages, and all races.
muscular dystrophy
Is an inherited condition that comes on in mid-life. It causes the progressive breakdown of nerve cells in the brain, leading to a loss of brain and muscle function.
Midlife age 30 -40
HUNTINGTON’S DISEASE
is female or male Most common among , hemophilia is characterized by a deficiency in blood clotting leading to abnormal bleeding.
males
is characterized by a deficiency in blood clotting leading to abnormal bleeding.
No normal blood clotting
HEMOPHILIA
THREE TYPES OF INFLAMMATORY DISEASE:
INFECTIVE DISEASE: Result from invasion by microorganisms such as viruses, bacteria, or fungi
TOXIC DISEASE: Result from poisoning by biologic substances
ALLERGIC DISEASE: An overreaction of the body’s own defenses.
Results from the body’ reaction to a localized injurious agent.
INFLAMMATORY DISEASE
THREE TYPES OF INFLAMMATORY DISEASE: Result from invasion by microorganisms such as viruses, bacteria, or fungi
INFECTIVE DISEASE.
Any of the diseases or disorders that disrupt normal metabolism, the process of converting food to energy on a cellular level. Thousands of enzymes participating in numerous interdependent metabolic pathways carry out this process.
METABOLIC DISEASE
THESE INCLUDE ENDOCRINE DISORDERS AND DISTURBANCES OF FLUID AND ELCTROLYTE BALANCE.
METABOLIC DISEASE
THREE TYPES OF INFLAMMATORY DISEASE: An overreaction of the body’s own defenses.
ALLERGIC DISEASE
may consist of hypersecretion, causing an overactivity of the target organ or insufficient secretion, resulting in underactivity.
ENDOCRINE DISORDERS
the most common disturbance of fluid balance.
DEHYDRATION
Caused by deterioration of the body. is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time. In neurodegenerative diseases cells of the central nervous system stop working or die via neurodegeneration.
DEGENERATIVE DISEASES
is the sum of all physical and chemical processes in the body.
METABOLISM
THREE TYPES OF INFLAMMATORY DISEASE: Result from poisoning by biologic substances
TOXIC DISEASE
Although they are usually associated with the aging process, some degenerative condition may exist in what patients
younger patients.
Give a relief from pain but no healing
DEGENERATIVE DISEASES
May result from mechanical forces such as crushing or twisting of a body part.
TRAUMATIC DISEASES
In addition, disorders resulting in
fractures
TRAUMATIC DISEASES
May result from mechanical forces such as crushing or twisting of a body part.
In addition, disorders resulting in fractures. It may also injure what
soft tissues
it may injure soft tissues even if the skin is not broken.
Traumatic injuries
an injury of soft parts associated with rupture of the skin.
WOUND
Are conditions that cause tumor growth: both benign and malignant.
NEOPLASTIC DISEASE
are noncancerous growths. They usually grow slowly and can’t spread to other tissues.
Benign tumors
THREE DISEASES COMMONLY ASSOCIATED WITH THE AGING PROCESS:
ATHEROSCLEROSIS
OSTEOPOROSIS
OSTEOARTHRITIS
are cancerous and can grow slowly or quickly.
Malignant tumors
general term often used to denote various types of malignant neoplasms.
CANCER
bleeding into the tissue spaces as a result of capillary rupture
BRUISE OR CONTUSION:
the spread of cancer cells.
METASTASIS.
one type of cancer and is derived from epithelial tissue.
CARCINOMA
another cancer which arises from connective tissue.
SARCOMA
can be serious or life-threatening. It depends on the type. Most of them have no cure. Treatments may help Improve symptoms, relleve pain, and Increase mobility.
Degenerative nerve diseases
The choice of which modality or combination of modalities depends on many factors, including the type of
cancer, its location and stage, and treating oncologist.
THE PRIMARY TREATMENT MODALITIES ARE:
SURGERY
CHEMOTHERAPY
RADIATION THERAPY
THE GOAL OF TREATMENT MAY BE:
CURATIVE: allowing the patient to remain free of disease for 5 years or more.
PALLIATIVE: designed to relieve pain when curing isn’t possible.
THE GOAL OF TREATMENT MAY BE:
designed to relieve pain when curing isn’t possible.
PALLIATIVE
THE GOAL OF TREATMENT MAY BE:
CURATIVE: allowing the patient to remain free of disease for how many years
5 years or more.
THE GOAL OF TREATMENT MAY BE:
allowing the patient to remain free of disease for 5 years or more.
CURATIVE