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pharmacology 2 Midterm > midterm 1 pq 2022 > Flashcards

midterm 1 pq 2022 Flashcards

1
Q

Amikacin is active against…

A: MRSA
B: Both of them
C: Pasteurella multocida
D: None of them

A

B: Both of them

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2
Q

what is the mechanism of action of lincosamides?

A: Time- dependent bactericidal
B: Inhibition of folic acid synthesis
C: inhibition of protein synthesis
D: cell wall synthesis inhibition

A

C: inhibition of protein synthesis

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3
Q

which agent can be effective against Pseudomonas aeruginosa among the following drug?

A: Tobramycin
B: Amoxicillin with clavulanic acid
C: None of them
D: Spectinomycin

A

A: Tobramycin

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4
Q

which agent can be used in Lawsonia intracellularis infection?

A: Both of them
B: None of them
C: Tylosin
D: Ceftiofur

A

C: Tylosin

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5
Q

inhibition of dihydrofolate- reductase is a ………………… in antimicrobial therapy.

A: None of them
B: Common target
C: Unique target
D: Similar target

A

D: Similar target

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6
Q

Amoxicillin is NOT effective against:

A: Chlamydophila spp
B: Pseudomonas spp
C: Mycoplasma spp
D: None of them

A

D: None of them

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7
Q

Cephalosporins are excreted ….

A: Both of them
B: Via the bile
C: Via the kidney
D: None of them

A

A: Both of them

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8
Q

It has the broadest spectrum from the listed agents:

A: Cefadroxil
B: Cefazolin
C: Cefquinome
D: Cefalexin

A

C: Cefquinome

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9
Q

what is the mechanism of action of aminoglycosides?

A: Cell wall synthesis inhibition
B: Bacteriostatic
C: Inhibition of bacterial cell wall synthesis
D: inhibiton of protein synthesis

A

D: inhibiton of protein synthesis

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10
Q

which bacterium is ab ovo resistant to the beta- lactam antibiotics?

A: Escherichia coli
B: Mycoplasma hyopneumoniae
C: Pseudomonas aeruginosa
D: Staphylococcus aureus

A

B: Mycoplasma hyopneumoniae

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11
Q

what is the mechanism of action of macrolides?

A: inhibition of deoxyribonucleic acid synthesis

B: Inhibition of protein synthesis on the 50S ribosome subunit

C: Concentration dependent bactericidal

D: inhibition of peptidoglycan synthesis

A

B: Inhibition of protein synthesis on the 50S ribosome subunit

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12
Q

Which of the following agents has postantibiotic effect?

A: All of them
B: Piperacillin
C: Phenoxymethylpenicillin
D: Cefalexin

A

A: All of them

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13
Q

which agent would you use in an Escherichia coli UTI ( urinary tract infection)?

A: Amoxicillin
B: Oxacillin
C: Phenoxymethylpenicillin
D: None of them

A

A: Amoxicillin

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14
Q

what is the mode of action of aminoglycosides in general?

A: Concentration - dependent bactericidal

B: Time - dependent bactericidal

C: inhibition of protein synthesis on the 50S ribosome subunit

D: None of these

A

A: Concentration - dependent bactericidal

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15
Q

Piperacillin is NOT effective against:

A: Both of them
B: Mycoplasma spp
C: Pseudomonas spp
D: None of them

A

B: Mycoplasma spp

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16
Q

Cefalexin belongs to the ….

A: 1st generation cephalosporins
B: 4th generation cephalosporins
C: 2nd generation cephalosporins
D: 3rd generation cephalosporins

A

A: 1st generation cephalosporins

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17
Q

which statement is NOT true for chloramphenicol?

A: It can cause dose- independent aplastic anaemia
B: It cannot be given to food- producing animals
C: it can be used topically in ophthalmic products
D: It is effectively used in sheep foot rot

A

D: It is effectively used in sheep foot rot

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18
Q

Which cephalosporin has pronounced elimination via the bile as well?

A: Cefuroxime
B: Cefalexin
C: None of the answers is correct
D: None of any cephalosporins eliminated via the bile, because they are only eliminated via the urine

A

C: None of the answers is correct

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19
Q

Which combination can lead to antagonistic effect?

A: All of them
B: Tylosin + valnemulin
C: Amikacin + metronidazole
D: Lincomycin + spectinomycin

A

B: Tylosin + valnemulin

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20
Q

which combination can lead to additive effect?

A: All of them
B: Tylosin + tulathromycin
C: Ceftiofur + tulathromycin
D: Metronidazole + gentamicin

A

D: Metronidazole + gentamicin

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21
Q

Lincomycin can be used in….

A: Mycoplasmosis in poultry
B: None of them
C: Both of them
D: Strangles in horses

A

A: Mycoplasmosis in poultry

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22
Q

Doxycycline can be effective against:

A: Borellia burgdorferi
B: Anaplasma phagocytophilum
C: Mycoplasma haemofelis
D: All of them

A

D: All of them

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23
Q

Which agent can be used in Lawsonia intracellularis infection?

A: Ceftiofur
B: Tylosin
C: None of them
D: Both of them

A

B: Tylosin

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24
Q

which substance belongs to CIA Highest Priority (AMEG B) of antibiotics category?

A: Lincomycin
B: Streptomycin
C: Cefuroxime
D: Colistin

A

D: Colistin

25
Q

if a Pseudomonas aeruginosa strain is resistant to gentamicin, the following agent can still be effective:

A: Neomycin
B: Amikacin
C: Streptomycin
D: None of them can be effective, they are all aminoglycosides

A

B: Amikacin

26
Q

Clindamycin can be used in…

A: oral cavity infections
B: All of them
C: Osteomyelitis
D: Anal sacculitis

A

A: oral cavity infections

27
Q

What is the mode of action of lincosamides?

A: time - dependent bactericidal
B: None of these
C: concentration - dependent bactericidal
D: Bacteriostatic

A

D: Bacteriostatic

28
Q

which agent can be used in lawsomnia intracellularis infection?

A: Tiamulin
B: Lincomycin
C: None of them
D: Both of them

A

D: Both of them

29
Q

which aminoglycosides is the safest among the following?

A: Spectinomycin
B: Streptomycin
C: Tobramycin
D: Neomycin

A

A: Spectinomycin

30
Q

which is NOT true for cefalexin?

A: it is concentration - dependent bactericidal
B: it is a first - generation cephalosporin
C: it has postantibiotic effect
D: it is not inactivated by beta- lactamase producing staphylococcus pseudointermedius

A

A: it is concentration - dependent bactericidal

31
Q

it has the broadest spectrum from the listed agents:

A: Cefazolin
B: Cefadroxil
C: Cefakexin
D: Cefquinome

A

D: Cefquinome

32
Q

select the correct answer! aminoglycosides body distribution is generally ….

A: Poor, they can barely cross the special barriers

B: Excellent, they can cross both the special barriers and the cell membrane

C: Poor, they are quickly eliminated from the body even if they are given in injections

D: Good, they can barely enter the cells, but they can cross the blood - milk barrier

A

A: Poor, they can barely cross the special barriers

33
Q

most effective in bacterial meningitis from the listed agents

A: Cefovecin
B: Ceftriaxone
C: Pivampicillin
D: Amoxicillin + clavulanic acid

A

B: Ceftriaxone

34
Q

what is the mode of action of pleuromutilins?

A: Concentration - dependent bactericidal
B: None of these
C: bacteriostatic
D: Time - dependent bactericidal

A

C: bacteriostatic

35
Q

which agent(s) would you use in a Pseudomonas aeruginosa infection?

A: Piperacillin + tazobactam
B: none of them
C: flucloxacillin
D: Amoxicillin + clavulanic acid

A

A: Piperacillin + tazobactam

36
Q

what is the mechanism of action of lincosamides?

A: inhibition of protein synthesis on the 50S

B: inhibition of protein synthesis on the 30S ribosome subunit

C: innhibition of peptidoglycan synthesis

D: inhibition of deoxyribonucleic acid synthesis

A

A: inhibition of protein synthesis on the 50S

37
Q

There´s NO glycoside bond in the structure of this antibiotic:

A: Spectinomycin
B: Streptomycin
C: Amikacin
D: All of them have glycoside bonds

A

A: Spectinomycin

38
Q

Doxycycline can be effective against:

A: both of them
B: Bordetella bronchiseptica
C: Escherichia coli
D: None of them

A

A: both of them

39
Q

which statement is true for tetracyclines?

A: They are highly active antibiotics resistance is rare
B: Divalent cations decrease their oral bioavailability
C: They have direct anthelminthic activity
D: They have wide spectrum of activity, but mycoplasma spp are ab ovo resistant

A

B: Divalent cations decrease their oral bioavailability

40
Q

which cephalosporin has pronounced elimination via the bile as well?
A: Cefuroxime
B: None of any cephalosporins eliminated via the bile, because they are eliminated via the urine
C: None of these answers is correct
D: Cefalexin

A

C: None of these answers is correct

41
Q

which agent can be used in Lawsonia intracellularis infection?

A: None of them
B: Ceftiofur
C: Both of them
D: Tylosin

A

D: Tylosin

42
Q

which substance belongs to CIA Highest Priority (AMEG B) category?

A: Streptomycin
B: Cefuroxime
C: Colistin
D: Lincomycin

A

C: Colistin

43
Q

Neomycin is active against…..

A: None of them
B: Clostridium perfringens
C: Fusobacterium necrophorum
D: Both of them

A

A: None of them

44
Q

Inhibition of cell wall synthesis is….

A: Unique target
B: Similar target
C: None of them
D: Common target

A

A: Unique target

45
Q

What is the mode of action of pleuromutilins?

A: Bacteriostatic
B: Time-dependent bactericidal
C: Concentration-dependent bactericidal
D: Agent-dependent bactericidal

A

A: Bacteriostatic

46
Q

Which agent can be given IV?

A: Amoxicillin trihydrate
B: Benzathine benzylpenicillin
C: Procaine benzylpenicillin
D: Benzylpenicillin sodium

A

C: Procaine benzylpenicillin

47
Q

Which combination can lead to decreased efficacy?

A: Colistin + amoxicillin
B: Amoxicillin + clavulanic acid
C: Phenoxymethylpenicillin + florfenicol
D: Doxycycline + tulathromycin

A

C: Phenoxymethylpenicillin + florfenicol

48
Q

Which substance belongs to the CIA Highest Priority (AMEG B) category?

A: Cefapirin
B: Ceftiofur
C: Cefadroxil
D: Cefalexin

A

B: Ceftiofur

49
Q

Amoxicillin is active against….

A: Pseudomonas spp.
B: Chlamydophila spp.
C: None of them
D: Mycoplasma spp.

A

C: None of them

50
Q

Cefalexin belongs to the…

A: 4th generation cephalosporins
B: 1st generation cephalosporins
C: 3rd generation cephalosporins
D: 2nd generation cephalosporins

A

B: 1st generation cephalosporins

51
Q

Prevalence of resistance is highest in case of this agent amoung followings:

A: Amikacin
B: Tobramycin
C: Neomycin
D: streptomycin

A

D: streptomycin

52
Q

what is the aim when colistin is used?

A: Both should be achieved
B: None of them is true
C: The drug concentration should be above the MIC as long as possible
D: The drug concentration should be above the MIC as much as possible

A

D: The drug concentration should be above the MIC as much as possible

53
Q

Effective against Pseudomonas aeruginosa:

A: Cefoperazon
B: Ceftiofur
C: Cefovecin
D: Cefuroxime

A

A: Cefoperazon

54
Q

what does MIC stand for?

A: Median inhibitory concentration
B: Maximum inhibitory concentration
C: Minimum inhibitory concentration
D: Mean inhibitory concentration

A

C: Minimum inhibitory concentration

55
Q

Phenicols can be used in….

A: None of them
B: Bovine respiratory disease complex
C: Both of them
D: Aeromonas salmonidae infection

A

C: Both of them

56
Q

What is the mode of action of tetracyclines?

A: Time-dependent bactericidal
B: Concentration-dependent bactericidal
C: Agent-dependent bactericidal
D: Bacteriostatic

A

D: Bacteriostatic

57
Q

This bacterium usually does not produce beta- lactamase enzymes

A: Streptococcus suis
B: Staphylococcus aureus
C: Pseudomonas aeruginosa
D: Escherichia coli

A

A: Streptococcus suis

58
Q

This side effect is NOT characteristic to phenicols

A: Severe kidney damage
B: Dose-dependent anaemia
C: Tissue irritation
D: Immunosuppression

A

A: Severe kidney damage

59
Q

Which combination can lead to antagonistic effect?

A: All of them
B: Metronidazole + gentamicin
C: Tetracycline + tulathromycin
D: Ceftiofur + doxycycline

A

D: Ceftiofur + doxycycline

pharmacology 2 Midterm (5 decks)

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