Midterm 1 - Neuroanatomy, Blood Supply, MCDB, CNS, PNS, CNs Flashcards
Sectioning the Brain
(Image)
Directions and the Brain
Top of Brain - Dorsal (also the back)
Bottom of Brain - Ventral (also the belly)
Front - Rostral (anterior)
Back - Caudal (posterior)
Lateral - Towards side
Medial - Towards middle
Planes of the Brain
(Image)
Lobes of the Brain
(Image)
Sulcus vs. Fissure vs. Gyrus
Brain is gyrencephalic.
Sulcus
- Groove
Fissure
- Deep groove
Gyrus
- Bump
Ventricles
(Image)
- Lateral (2)
- 3rd
- 4th
- Cerebral Acqueduct
Corpus Callosum
- Thick bundle of axons that facilitates the transmission of information from one hemisphere to the other.
- Connects like areas of brain.
CSF
- Fills ventricles
- Made by choroid plexus of each ventricle. The CP of each ventricle gets a blood supply and takes what it wants to make CSF (clear part of blood).
- Drains to 4th ventricle where it becomes a part of the blood supply again.
Meninges in the CNS
- Protective sheaths around brain and spinal cord.
- Pia Mater - thin, delicate layer on top of brain
- Arachnoid Layer - Hollow space where the blood vessels supply the brain with blood
- Dura Mater (outermost) - Beneath skull; thick, tough
Meninges in the PNS
No arachnoid layer, just dura and pia.
What does blood carry to the brain?
- Glucose
- Oxygen
Brain is only 2% of body’s weight but uses 20% of body’s oxygen and 20% of body’s glucose.
7 min w/o oxygen and neurons begin to die.
Arteries Going to Brain
- Carotid (2) - come off front of heart, go up front of spinal cord, go to front of brain
- Vertebral (2) - come off heart and go up spinal cord, supplying blood to the back 1/2 of the brain (go thru hole in bottom of skull: “foramen magnum”).
Primary Vein Leaving Brain
Jugular (carries de-oxygenated blood away)
2 Ways Blood Supply to Brain Is Interrupted
- Stroke/CVA - Plaque in large artery breaks free and gets stuck in smaller branch (in brain).
- Anneurism - Outpouching of artery. Bursts and blood doesn’t get to the neurons it needs to get to.
Blood-Brain Barrier
Comprised of tight junctions of epithelial cells that make up the walls of arteries in the brain. Actually the lining of the arteries themselves.
MCDB
Molecular Cellular Developmental Biology
- We start as a tube and develop from the inside out, forming 6 layers that become the brain.
- Proliferation of neural stem cells in SVZ
- Migrate to radial glia cells
- Differentiate as climb up radial glia