Midazolam (Versed)

Question 1

Midazolam (Versed)
Classification

Answer 1

Benzodiazepine
Anticonvulsant
Sedative
Hypnotic

Question 2

Midazolam (Versed)
Mechanism of Action

Answer 2

Postive allosteric modulator for GABAa receptors. Binds to benzo receptor sites on chloride channels and potentiales binding and effects of GABA (increases intracellular Cl concentration leading to hyperpolarization of the cell)

Question 3

Midazolam (Versed)
Onset of Action

Answer 3

3-5 min IV
15 min IM

Question 4

Midazolam (Versed)
Peak Effects

Answer 4

20-60 min

Question 5

Midazolam (Versed)
Duration of Effect

Answer 5

<2hrs IV
1-6 hrs IM

Question 6

Midazolam (Versed)
Half-life

Answer 6

1-4 hrs

Question 7

Midazolam (Versed)
Indications/Field Use

Answer 7

Pre-medication for cardioversion or TCP
Post-intubation sedation
Seizure

Question 8

Midazolam (Versed)
Contraindications

Answer 8

Hx of narrow-angle glaucoma
Hypotension

Question 9

Midazolam (Versed)
Side Effects/Adverse Reactions

Answer 9

Hypotension
Drowsiness
Amnesia
Respiratory depression
AMS
Blurred Vision
N/V

Question 10

Midazolam (Versed)
Adult Dose

Answer 10

Pre-medication 2-5mg (0.5mg/kg) slow IV, IO, IM
Post-intubation 2-5mg q 5-10 min slow IV/IO
Seizure 2-6 mg IV; 10mg IM; 0.2mg/kg IN (max 10mg)

Question 11

Midazolam (Versed)
Pedi Dose

Answer 11

0.2mg/kg slow IV (max 10mg)

Question 12

Midazolam (Versed)
Precautions

Answer 12

May cause CNS and respiratory depression
caution with acute alcohol intoxication

Question 13

Midazolam (Versed)
Drug-drug Interactions

Answer 13

Additive effects with CNS depressants and alcohol