Lorazepam (Ativan)

Question 1

Lorazepam (Ativan)
Classification

Answer 1

Anticonvulsant
Sedative
Hypnotic
Benzodiazepine

Question 2

Lorazepam (Ativan)
Mechanism of Action

Answer 2

Postive allosteric modulator for GABAa receptors. Binds to benzo receptor sites on chloride channels and potentiales binding and effects of GABA (increases intracellular Cl concentration leading to hyperpolarization of the cell)

Question 3

Lorazepam (Ativan)
Onset of Action

Answer 3

1-5 min IV
15-30 min IM

Question 4

Lorazepam (Ativan)
Peak Effects

Answer 4

15-20 min IV
2 hrs IM

Question 5

Lorazepam (Ativan)
Duration of Effects

Answer 5

6-8 hrs

Question 6

Lorazepam (Ativan)
Half-life

Answer 6

10-20 hrs

Question 7

Lorazepam (Ativan)
Indications/Field Use

Answer 7

Major motor seizures
Pre-medication for cardioversion or TCP
Acute Anxiety
Alcohol withdrawal/delirium tremens
Post-intubation sedation

Question 8

Lorazepam (Ativan)
Contraindication

Answer 8

Hypersensitivity

Question 9

Lorazepam (Ativan)
Side Effects/Adverse Reactions

Answer 9

hypotension, drowsiness, anmesia, respiratory depression, blurred vision, AMS, N/V

Question 10

Lorazepam (Ativan)
Adult Dose

Answer 10

*Seizure 4mg IV, IO
*Pre-med/anxiety, withdrawal 0.5-2mg (0.1mg/kg) slow IV/IO, 1-4mg IM
*Post-Intubation 2-4mg slow IV/IO q 5-10 min

Question 11

Lorazepam (Ativan)
Pedi Dose

Answer 11

0.05mg/kg slow IV/IO

Question 12

Lorazepam (Ativan)
Precautions

Answer 12

May cause CNS and respiratory depression
Caution with acute alcohol intoxication

Question 13

Lorazepam (Ativan)
Drug-Drug Interactions

Answer 13

additive effects with CNS depressants and alcohol