Diazepam (Valium)

Question 1

Diazepam (Valium)
Classification

Answer 1

Anticonvulsant
Sedative
Benzodiazepine
Anxiolytic

Question 2

Diazepam (Valium)
Mechanism of Action

Answer 2

Postive allosteric modulator for GABAa receptors. Binds to benzo receptor sites on chloride channels and potentiales binding and effects of GABA (increases intracellular Cl concentration leading to hyperpolarization of the cell)

Question 3

Diazepam (Valium)
Onset of Action

Answer 3

1-5 min IV
15-30 min IM

Question 4

Diazepam (Valium)
Peak Effects

Answer 4

10 min IV
30-45 min IM

Question 5

Diazepam (Valium)
Duration of Effect

Answer 5

15-60 min

Question 6

Diazepam (Valium)
Half-life

Answer 6

20-50 hrs

Question 7

Diazepam (Valium)
Indications/Field Use

Answer 7

Major motor seizures
Premedication for cardioversion or TCP
Acute Anxiety

Question 8

Diazepam (Valium)
Contraindications

Answer 8

Hypersensitivity

Question 9

Diazepam (Valium)
Side Effects/Adverse Reactions

Answer 9

Hypotension
Hallucinations
Drowsiness
Amnesia
Respiratory depression
Blurred Vision
AMS
N/V

Question 10

Diazepam (Valium)
Adult Dose

Answer 10

Anxiety 2-5mg slow IV/IO
Seizure 5-10mg slow IV/IO
Sedative 5-15mg slow IV/IO

Question 11

Diazepam (Valium)
Pedi Dose

Answer 11

0.2mg/kg IV/IO (max 5mg)

Question 12

Diazepam (Valium)
Precautions

Answer 12

May cause CNS and respiratory depression
Caution with acute alcohol intoxication

Question 13

Diazepam (Valium)
Drug-drug interactions

Answer 13

Additive effects with CNS depressants and alcohol