Microtubule Motor Proteins Flashcards

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1
Q

Which direction do kinesins transport cargo along microtubules? What is the term for this?

A

Positive end of microtubules ( anterograde)

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2
Q

Which direction do dyneins transport cargo along microtubules? What is the term for this?

A

Negative end (reterograde)

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3
Q

Do dyneins and kinesins require ATP to transport cargo?

A

Yes

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4
Q

What speed do kinesins tend to travel?

A

Travel approx 600nm / s

[can span most cells (10 - 100 um) in seconds]

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5
Q

What is the function of kinesin-1?

A

Organelle transport

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6
Q

What is the function of kinesin-2?

A

Organelle transport

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7
Q

What is the function of kinesin-5?

A

Sliding microtubules past each other, eg; in relation to chromosome separation and polar microtubules

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8
Q

What is the function of kinesin-13?

A

Disassmebly of microtubules from positive and negative ends by hydrolysing ATP

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9
Q

How are dyneins linked to their cargo?

A

Via the large protein complex, dynactin

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10
Q

What kind of cargo do dyneins transport?

A

Vesicles and chromosomes

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11
Q

Which of kinesins and dyneins are larger?

A

Dyneins are larger than kinesins

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12
Q

What are tau tanlges?

A

Abnormal tau aggregates and causes tau tangles which block microtubule transport

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13
Q

What disease are tau tangles associated with?

A

Alzheimer’s disease

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14
Q

Which end of the spindle microtubules are associated with the spindle poles?

A

Negative

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15
Q

What are the names of the microtubules that make up the spindle?

A

Kinetochore microtubules
Polar microtubules
Astral microtubules

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16
Q

What is the purpose of the kinetochore microtubules?

A

To connect chromosomes to the spindle poles, via the kinetochore attachment site

17
Q

What is the purpose of the polar microtubules?

A

To hold the poles together and regulate the distance between them