Microglia Flashcards
Do microglia carry action potentials ?
no they are non neural cells in the CNS
What are the four main functions of glia cells?
- support surrounding neurones
- Supply nutrients and oxygen to neurones
- Insulate and facilitate synaptic communication
- Remove cell debris
What are the other roles of glia?
- guide migration in early development
- reg clearance of NT from cleft
- Role in brain disease
Where are microglia derived from? development layer?
the mesoderm/ yolk sac
Where are oligos and astrocytes derived from ?developmental layer?
neuroectoderm
Where are stem HMSCs derived from? developmental layer ?
myeloid
What happens by 6 weeks gestation?
vasculogenesis in the telencephalon
Endothelial BBB formation
What forms from 7 weeks of gestation?
blood-CSF barrier, CSF brain barrier, Pia-arachnoid
All have tight junctions
What progenitors do glia differentiate from in early development ?
neural progenitors
How do oliogodendrites differentiate ?
Stepwise
From Neural glia 2 progenitors to mature myelinating oligodendrities
Where do Schwann cell precursors give rise ?
in the neural crest
peripheral sensory and autonomic neurones
satellite cells of the DRG
Where are multipoint radial-like glia thought to derive?
neural and glia cells
What are the macrophage subpopulations in the brain ?
- microglia
- meninges
- choroid
- perivascular space
- dendritic
What are the characteristics of microglial population ?
Mosaic like
In the parenchyma
variable densities in different regions
What are the roles of microglia in the immune compartment of the brain ? (5)
Surveillance, proliferating, pruning, phagocytosis, neuromodulatory
