Microbiology: Hepatitis virus 4

Question 1

Which hepatitis viruses cause Cirrhosis?

Answer 1

HBV
HCV
HDV

Question 2

Which hepatitis viruses cause acute liver failure?

Answer 2

HAV
HBV
HEV

Question 3

Which hepatitis viruses can be cured?

Answer 3

HCV

Not HBV

Question 4

When should you always screen for HBV?

Answer 4

Cancer chemotherapy

HIV treatment

Question 5

What two drugs are used for HBV?

Answer 5

Entecavir
Tenofovir
need CT scan every 6 months b/c of HCC risk

Question 6

Which hepatitis viruses can be vaccinated against?

Answer 6

HAV

HBV

Question 7

What are the signs and symptoms of acute hepatitis?

Answer 7

From HAV, HEV, HBV
Fever, fatigue, abd pain
enlarged liver
AST/ALT > 1000, increased PT, Increased bilirubin

Question 8

What are the relative outcomes for acute hepatitis?

Answer 8

Resolution&raquo_space; Chronic HBV&raquo_space;»»> fulminant hepatic failure (encephalopathy)

Question 9

What hepatitis viruses cause chronic hepatitis?

Answer 9

HBV
HCV
HBV + HDV

Question 10

What is the most common hepatitis virus worldwide?

Answer 10

HBV

Question 11

What is the most common hepatitis virus in the US?

Answer 11

HCV

Question 12

What is the HCV test of choice?

Answer 12

Ab-HepC –> PCR

Question 13

Review all the HBV tests?

Answer 13

1. HBsAg: acutely infected or carriers = screening test; all chronic cases have this
2. Anti-HBs: past infection (resolved) or vaccinated
3. HBeAg: active infection, ↑risk of transmission; ↑DNA viral levels
4. Anti-HBe: carrier with ↓risk
5. Anti-HBc: past infection (notice there is no core capsid marker); this is how you distinguish past infection vs. vaccine
6. IgM Anti-HBc: acute infection
7. HBV DNA