GI physiology: Regulation of appetite

Question 1

What is the effect of CCK on appetite?

Answer 1

CCK –> decreased appetite, decreased gastric emptying

Question 2

What is the role of PYY in appetite regulation?

Answer 2

SI –> PYY –> Blocks NPY/AgRP –> Decreased food intake, increased gastric emptying

Question 3

What are the roles of leptin and insulin in appetite regulation?

Answer 3

Leptin + insulin –> Block NPY, stimulate POMC –> Decreased food intake, increased metabolism

Question 4

What is the role of grehlin in appetite regulation?

Answer 4

Ghrelin –> stimlulates NPY –> stimlulate food intake, decreased gastric emptying.

Question 5

What is the role of alpha-MSH in appetite regulation?

Answer 5

Arcuate nucleus –> POMC –> alpha-MSH –> MC4R neurons –> Increased metabolism, decreased food intake.

Question 6

What is the role of AgRP in appetite regulation?

Answer 6

Arcuate nucleus –> AgRP –> Blocks MC4R –> decreased metabolism, increased food intake

Question 7

What is the role of NPY in appetite regulation?

Answer 7

Arcuate nucleus –> NPY –> Y, R neurons –> decreased metabolism, increased food intake

Question 8

What factors stimulate hunger?

Answer 8

NPY
AgRP
Ghrelin

Question 9

What blocks NPY and AgRP?

Answer 9

Metabolism and satiety

Question 10

What factors suppress hunger?

Answer 10

Leptin
Insulin
PYY
CCK