Microbiology Flashcards

1
Q

Meningitis in HIV

A

Cryptococcus

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2
Q

Main side effect of isoniazid

A

peripheral neuropathy

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3
Q

Peyer’s patches, gram negative non lactose fermenter

A

Yersinia

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4
Q

Rash begins on face, lymphadenopathy

A

Rubella

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5
Q

well formed spherical lung cavity

A

aspergillus

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6
Q

HBsAg

A

Positive in acute or chronic hepatitis

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7
Q

Trauma, open wound, gas gangrene, what organism?

A

Clostridium

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8
Q

LLL pneumonia, haemoptysis, cavitation, gram –ve

A

h. influenzae

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9
Q

encapsulated bacteria

A

h. influenza
meningococcus
strep pneumoniae

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10
Q

Sewage worker + microscopic agglutination test

A

Leptospirosis

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11
Q

Gram positive lower urinary tract symptoms in a woman

A

Staphylocccus saprophyticus

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12
Q

Treatment for gonorrhoea?

A

IM ceftriaxone and stat dose oral azithromycin

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13
Q

Haemorrhagic cystitis, virus

A

Adenovirus

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14
Q

Inactive vaccines?

A

rabies
hepatitis A
influenza (intramuscular)

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15
Q

Patient with sore throat develops rash after taking amoxicillin, what does she have?

A

infectious mononucleosis (EBV)

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16
Q

Schaffners dots on blood film

A

Malaria vivax/ovale

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17
Q

Nigeria, rats, haemorrhagic

A

Lassa fever

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18
Q

What on non culture samples shows contamination?

A

Squamous epithelial cell

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19
Q

Antibiotic for mastitis during breastfeeding

A

flucloxacillin

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20
Q

Chlamydia treatment

A

doxycycline (7 day course) or azithromycin (single dose)

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21
Q

Co receptors involved with HIV

A

CXCR5/CCR5

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22
Q

Transmitted by sandfly

A

Leishmania; skin ulcer at site of bite

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23
Q

Drug to treat falciparum malaria?

A

Artesunate

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24
Q

malarial merozites are where?

A

Blood cells (from ‘M’arrow)

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25
Q

IgM anti-HBc

A

Indicates acute infection

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26
Q

Unpasteurised dairy/animal contact

A

Brucellosis

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27
Q

14-3-3 positive in CSF

A

Sporadic CJD

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28
Q

Negri bodies

A

Rabies

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29
Q

Meningitis in kids younger than 3 months

A

S. pneumoniae

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30
Q

CSF in bacterial meningitis?

A

Cloudy
Low glucose
High protein
Polymorphs

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31
Q

Beta lactam with anti-pseudomonal activity

A

Piperacillin

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32
Q

silver stain / flying saucers/ boats

A

PCP

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33
Q

EEG shows periodic triphasic changes

A

Sporadic CJD

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34
Q

HBeAg

A

Currently infective

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35
Q

How to diagnose variant CJD

A

tonsillar biopsy

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36
Q

Insect bite: pains, facial nerve palsy, palpitations, headaches and fever. Organism?

A

Borelia burgdorferi

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37
Q

Infection that carries risk of hydrops fetalis if acquired before 20 weeks?

A

Parvovirus b19

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38
Q

Tx for campylobacter

A

Erythromycin

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39
Q

coccobaccili

A

haemophilus influenzae (gram neg)
chlamydia
bordatella

40
Q

What part of HIV binds to CD4 on T cells?

A

Gp120

41
Q

Syphilis treatment

A

IM BenPen

42
Q

Abx for listeria?

A

amoxicillin / ampicillin

43
Q

Malaria hypnozoites are where?

A

in Hepatic cells

44
Q

Organism that can cause osteomyelitis

A

Salmonella

45
Q

Tx of Hep B?

A

PegIFN alpha 2a

46
Q

Arbovirus, America, mosquitoes, polio-like

A

West Nile Virus

47
Q

Abx for Legionella ? Class?

A

Clarithromycin (macrolide)

48
Q

gram positive rods

A
actinomyces
bacillus cereus
clostridium
diphtheria
listeria
49
Q

anti-HBs

A

Indicates immunity after infection has been cleared, either from natural or vaccine

50
Q

Which type of hepatitis viruses are RNA viruses?

A

Hep A, C

51
Q

Guidelines for women who present with a primary herpes infection in their third trimester of pregnancy?

A

Oral aciclovir 400 mg TDS until delivery

IV aciclovir for infant if vaginal del/SROM

52
Q

Malaria spherocytes are where?

A

Skin

53
Q

Neonatorum ophthalmia

A

Chlamydia trachomatis

54
Q

IVDU, dry cough, Bilateral interstitial shadowing

A

PCP

55
Q

Gram +ve grape clusters with cavitation

A

S. Aureus

56
Q

Tx of hep b?

A

Interferon alpha and lamivudine

57
Q

Fungal pneumonia in immunocompromised

A

Aspergillus

58
Q

Undulant fever, malaise, rigors, sweating, animal contact

A

brucellosis

59
Q

Which common condition can be treated with drugs that target with TNF, IL-17 and IL-12/23?

A

Psoriasis

60
Q

Mechanisms of Abx resistance?

A

Bypass - bypass antibiotic sensitive step in pathway e.g MRSA
Enzyme - Enzyme-mediated drug inactivation e.g beta-lactamases.
Accumulation - Impairment of accumulation of the drug, e.g. tetracycline resistance.
Target - Modification of the drugs target in the microbe e.g. quinolone resistance

61
Q

Bat’s wing on CXR

A

PCP

62
Q

TB treatment

A

R and I for 6 month, P and E for first 2

63
Q

What on non culture sample shows infection with coliform

A

Nitrite

64
Q

Liver cysts, dogs, sheep

A

hydatid disease

65
Q

Malarial gametocytes are where?

A

Mosquitoes (‘G’obbled back up)

66
Q

Target shaped rash, hiking outdoors

A

Lyme disease

67
Q

Abx for haemophilus influenza?

A

Amoxicillin (beta lactam)

68
Q

Rash starts behind the ears, Koplik spots

A

Measles

69
Q

Tx for c diff. colitis?

A

Metronidazole

70
Q

Optochin sensitive

A

Strep. pneumoniae

71
Q

Herpes viruses that cause cervical cancer vs warts?

A

HHV 16 and 18 = cancer
HHV 6 and 11 = warts

GARDASIL is quadravalent

72
Q

ground glass x ray

A

PCP

73
Q

Bird contact, cytoplasmic inclusions

A

Psittacosis

74
Q

CSF in TB meningitis?

A

Clear
Low glucose
High +++ protein
Lymphocytes

75
Q

Subacute infective endocarditis

A

S. viridians

76
Q

Disease which if transmitted to baby: they can initially be symptomless but then come down with problems

A

CMV

77
Q

Acute infective endocarditis

A

S. auerus

78
Q

Which type of hepatitis viruses are DNA viruses?

A

Hep B

79
Q

Cause of Kaposi’s sarcoma?

A

HHV 8 in AIDS

80
Q

“spaghetti and meatballs” appearance

A

pityriasis vericolor

81
Q

Abx for Group A Strep? Class?

A

IV benzylpenicillin (beta lactam)

82
Q

Painless round black lesions and rims of oedema

A

Anthrax

83
Q

Tx for septic arthritis

A

IV cefotaxime

84
Q

What would you target with psoriasis Tx?

A

TNF
IL-17
IL-12/23

85
Q

Reactive arthritis, erythema nodosum, enterocolitis

A

Yersinia

86
Q

Meningitis in kids older than 3 months

A

Neisseria meningitidis, Haemophilus in unvaccinated children

87
Q

2m on with fever, elevated LFTs, flagellate organism

A

Toxoplasmosis

88
Q

Abdo pain and fever, no diarrhoea

A

Salmonella

89
Q

What class is Gentamicin? MOA?

A

Gentamicin is an aminoglycoside which works by inhibiting protein synthesis and is used in gram negative sepsis.

90
Q

smokers, gram negative pneumonia

A

M cattarhilis (moraxella)

91
Q

spirochaetes

A
treponema pallidum (syphillus)
leptospirosis
92
Q

Painless genital ulcer, balanitis, proctitis, cervicitis

A

Early LGV

93
Q

CSF in viral meningitis?

A

Clear
60-80% plasma glucose
Normal/raised protein
Lymphocytes

94
Q

Pulmonary infection, immunocompromised, found in soil assoc/ with bat or bird droppings

A

Histoplasmosis

95
Q

Post initial treatment, this strain of malaria requires Primaquine 30mg to eliminate liver parasites?

A

P. Vivax

96
Q

A gram-positive β-haemolytic coccus that can cause pharyngitis, erysipelas and cellulitis.

A

Strep pyogenes