Microbiology

Question 1

rabies morphology

Answer 1

bullet shaped, negative sense ssRNA
RNA dependent RNA polymerase E
coated

Question 2

Boaintang causes:

Answer 2

rabies

Question 3

stages of rabies

Answer 3

1. incubation period : averages depending on the site of wound, asymptomatic , retrograde
2. prodrome : 2-10 days with non specific symptoms and corresponds to invasion of dorsal root gang.
3. neurological phase : 2-7 days , correspond to invsion of the CNS and might be encephalitic or initial paralytic
4. coma : always death

Question 4

encephalitic furious rabies symptoms

Answer 4

hypersalivation > ANS dysfunction
hydrophobia and aerophobia > contraction of throat and respiratory muscles
foaming mouth

Question 5

most common sensitive technique for lab diagnosis of rabies is

Answer 5

PCR

Question 6

Negri bodies are seen in

Answer 6

pyramidal cells and purkinje cells
positive. only when condition is almost fatal

Question 7

rodent borne viruses are

Answer 7

arenaviridae
bunyaviridae (hentavirus)

Question 8

arenaviride members and their conditions

Answer 8

lessa virus > lessa fever
machupo virus > bolivian hemorrhage fever
jeinin virus > argentine hemorrhage, fever
choriomeningitis v. > lymphatic choriomeningitis

Question 9

bunyaviridae members and their dizs

Answer 9

hentavirus > hemorrhagic fever and renal syn.
sin nombre virus > hentavirus cardiopulmonary syn.

Question 10

arboviruses families are:

Answer 10

togavirus
flavivirus
reovirus
bunyavirus

Question 11

togavirus members, diz and vector

Answer 11

WEV, EEV, VEV > encephalitis
chickungunya v. , ross river fever > febrile

all caused by mosquitos

Question 12

flavivirus, what members cause febrile , what members are carried by ticks

Answer 12

dengue, west, zika > febrile
powassan annd tick borne encephalitis virus > ticks

the rest are carried by mosquitoes and cause encephalitis

Question 13

reovirus members and vector

Answer 13

colorado tick fever viruses and cause by ticks

Question 14

bunyaviruses members and vectors
on arboviruses

Answer 14

rift valley , sand fly > febrile by sandfly
crimean congo > febrile by ticks
california > encephalitis by mosquitoes

Question 15

• arenaviruses and filoviruses that cause hemorrhagic fevers
• bunyaviruses that cause encephalitis

Answer 15

• all but the choriomeningitis \ ebola and marburg v.
• la crosse encephalitis

Question 16

ribavirin is used as a

Answer 16

treatment of hentavirus and sin nombre viruses

Question 17

• horses , australia , respiratory and meningitis and highly fatal
• pigs , south asia , encephalitis and respiratory and highly fatal mortality

Answer 17

hendra virus
nipah virus

Question 18

life cycle of ticks is :

Answer 18

ELNA
(egg, larva , nymph , adult )

Question 19

how much does it take to see clinical signs of tick paralysis and where do tick usually bite

Answer 19

2- 7 days and starts with weakness of legs then ascending
nick or head

Question 20

ixodes usually causes

Answer 20

anaplasmosis , lyme , tbrf , babesiosis, powassan

TB LAP

Question 21

ambylyommma causes :

Answer 21

ehrlichiosis , heartland virus, stari, tularemia
SHET

Question 22

Dermacentor causes :

Answer 22

colorado tick fever and rocky mountain spotted fever

Question 23

ornithodors cause

Answer 23

TBRF tick borne relapsing fever

Question 24

most common type of prion disease in humans is”:

Answer 24

sporadic CJD

Question 25

cerebellar syndrome and ataxia are seen in

Answer 25

iatrogenic CJD

Question 26

common age for vCJD, accumulates in _____, transmitted by_____.

Answer 26

27 years, lymphoid tissue (tonsils ) surgical instruments and oral and tonsillectomy

Question 27

afflict nervous system via guts, ph is from 3-9 positive sense ssRNA

Answer 27

enterovirus or picornavirus

Question 28

enterovirus. infection is common in ____ and it usually is ____

Answer 28

children and asymptomatic

Question 29

post polio syndrome is in surviving cases of paralytic poli and happens after ____

Answer 29

20-40years after infection

Question 30

is a polio vaccine thats used less, have higher risk of vaccination ass diz , lifelong immunity with no need for repeated bosters

Answer 30

sabin live attinuated

Question 31

a polio vaccine thats: more used, no risk of vaccine ass diz, repeated boosters are needed

Answer 31

salk inactivated or killed

Question 32

type a coxackieviruse causes

Answer 32

falccid in mice aseptuc meningitis, febrile illness, herpania and HFM (16)

Question 33

type b coxackievirus causes

Answer 33

spastic in mice neonatal diz, myalgia, bornholm diz, myocarditis, pericarditis, hepatiits, meningitis

Question 34

boston fever cause is:

Answer 34

parechovirus type 16

Question 35

——: pneumonia & bronchiolitis ——: Not yet associated with clinical diseases ——: acute hemorrhagic conjunctivitis ——: HFM disease (second most common cause) ——: paralysis & meningo-encephalitis ——: hepatitis A → Hepatovirus

Answer 35

68 \69 \70 \71 \ 70 & 71 \72

Question 36

main syndrome is paroritis and might cause: meningitis, orchitis, oophoritis, pancreatitis

Answer 36

mumps

Question 37

paramyxovirus vaccine is:

Answer 37

MMR (live attenuated)

Question 38

fever, cough, kopliks spots, conjuctivitis are all seen in its complications can be

Answer 38

measles pneumonia , otitis media, enchephalitism, SSPE

Question 39

most common causes od tick paralysis are

Answer 39

dermacentor andersoni and varibils