Microbiology Flashcards
rabies morphology
bullet shaped, negative sense ssRNA
RNA dependent RNA polymerase E
coated
Boaintang causes:
rabies
stages of rabies
- incubation period : averages depending on the site of wound, asymptomatic , retrograde
- prodrome : 2-10 days with non specific symptoms and corresponds to invasion of dorsal root gang.
- neurological phase : 2-7 days , correspond to invsion of the CNS and might be encephalitic or initial paralytic
- coma : always death
encephalitic furious rabies symptoms
hypersalivation > ANS dysfunction
hydrophobia and aerophobia > contraction of throat and respiratory muscles
foaming mouth
most common sensitive technique for lab diagnosis of rabies is
PCR
Negri bodies are seen in
pyramidal cells and purkinje cells
positive. only when condition is almost fatal
rodent borne viruses are
arenaviridae
bunyaviridae (hentavirus)
arenaviride members and their conditions
lessa virus > lessa fever
machupo virus > bolivian hemorrhage fever
jeinin virus > argentine hemorrhage, fever
choriomeningitis v. > lymphatic choriomeningitis
bunyaviridae members and their dizs
hentavirus > hemorrhagic fever and renal syn.
sin nombre virus > hentavirus cardiopulmonary syn.
arboviruses families are:
togavirus
flavivirus
reovirus
bunyavirus
togavirus members, diz and vector
WEV, EEV, VEV > encephalitis
chickungunya v. , ross river fever > febrile
all caused by mosquitos
flavivirus, what members cause febrile , what members are carried by ticks
dengue, west, zika > febrile
powassan annd tick borne encephalitis virus > ticks
the rest are carried by mosquitoes and cause encephalitis
reovirus members and vector
colorado tick fever viruses and cause by ticks
bunyaviruses members and vectors
on arboviruses
rift valley , sand fly > febrile by sandfly
crimean congo > febrile by ticks
california > encephalitis by mosquitoes
- arenaviruses and filoviruses that cause hemorrhagic fevers
- bunyaviruses that cause encephalitis
- all but the choriomeningitis \ ebola and marburg v.
- la crosse encephalitis
ribavirin is used as a
treatment of hentavirus and sin nombre viruses
- horses , australia , respiratory and meningitis and highly fatal
- pigs , south asia , encephalitis and respiratory and highly fatal mortality
hendra virus
nipah virus
life cycle of ticks is :
ELNA
(egg, larva , nymph , adult )
how much does it take to see clinical signs of tick paralysis and where do tick usually bite
2- 7 days and starts with weakness of legs then ascending
nick or head
ixodes usually causes
anaplasmosis , lyme , tbrf , babesiosis, powassan
TB LAP
ambylyommma causes :
ehrlichiosis , heartland virus, stari, tularemia
SHET
Dermacentor causes :
colorado tick fever and rocky mountain spotted fever
ornithodors cause
TBRF tick borne relapsing fever
most common type of prion disease in humans is”:
sporadic CJD
cerebellar syndrome and ataxia are seen in
iatrogenic CJD
common age for vCJD, accumulates in _____, transmitted by_____.
27 years,
lymphoid tissue (tonsils )
surgical instruments and oral and tonsillectomy
afflict nervous system via guts,
ph is from 3-9
positive sense ssRNA
enterovirus or picornavirus
enterovirus. infection is common in ____ and it usually is ____
children and asymptomatic
post polio syndrome is in surviving cases of paralytic poli and happens after ____
20-40years after infection
is a polio vaccine thats
used less, have higher risk of vaccination ass diz , lifelong immunity with no need for repeated bosters
sabin
live attinuated
a polio vaccine thats:
more used, no risk of vaccine ass diz, repeated boosters are needed
salk
inactivated or killed
type a coxackieviruse causes
falccid in mice
aseptuc meningitis, febrile illness,
herpania and HFM (16)
type b coxackievirus causes
spastic in mice
neonatal diz, myalgia, bornholm diz, myocarditis, pericarditis, hepatiits, meningitis
boston fever cause is:
parechovirus type 16
——: pneumonia & bronchiolitis
——: Not yet associated with clinical diseases
——: acute hemorrhagic conjunctivitis
——: HFM disease (second most common cause)
——: paralysis & meningo-encephalitis
——: hepatitis A → Hepatovirus
68 \69 \70 \71 \ 70 & 71 \72
main syndrome is paroritis and might cause:
meningitis, orchitis, oophoritis, pancreatitis
mumps
paramyxovirus vaccine is:
MMR (live attenuated)
fever, cough, kopliks spots, conjuctivitis are all seen in
its complications can be
measles
pneumonia , otitis media, enchephalitism, SSPE
most common causes od tick paralysis are
dermacentor andersoni and varibils
