Microbiology 11: Zoonoses Flashcards

1
Q

Which 2 organisms are transmitted from UK farm/wild animals e.g chickens, cows ?

A

Campylobacter
Salmonella

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2
Q

Which bacteria is commonly transmitted from poorly BBQd poultry ?

A

Campylobacter

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3
Q

Which 4 organisms are transmitted from companion animals in the UK ?

A

Bartonella (kittens)
Toxoplasmosis
Ringworm
Psittacosis (parrot fever)

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4
Q

What is the treatment of a campylobacter infection ?

A

Supportive treatment- lots of water, paracetamol etc
Avoid contact with others and make sure regular hand washing

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5
Q

Which disease is caused by bartonella henselae infection in an immunocompetent patient ?

A

Cat scratch disease (mainly kittens)

  • transmitted from the cat into the persons mouth causing a Macule which may start to ouse
  • This can then cause regional adenopathy and even systemic systems such as fever, weight loss and night sweats.
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6
Q

What disease is caused by bartonella in an immune-compromised patient (HIV pt)?

A

Bacillary angiomatosis

  • You get skin Papules, Hepatitis and multi organ/vasculature involvement
  • Can be fatal especially in HIV patients.
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7
Q

Which disease transmitted from cats can cause foetal abnormalities in pregnant women ?

A

Toxoplasmosis (from the faeces)

Can cause still birth, progressive visual loss, motor and cognitive function loss

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8
Q

Which signs can toxoplasmosis cause in immunocompromised people ? (2)

A
  • Neuropathy
  • Seizures
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9
Q

A goat farmer from India presents with a month long history of fever, lethargy, loss of appetite, weight loss and sweating. On examination you notice he has one enlarged testicle. He admits to drinking unpasteurised milk from his goats.

Which organism is the likely cause of his infection ?

A

Brucella (he has brucellosis)

  • Presents almost exactly like extra pulmonary TB
  • comes from cattle and goats
  • Transmission: Unpasteurised milk, Undercooked meat
  • NB key difference is the big testicles / orchitis
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10
Q

This disease is transmitted from aerosolisation and inhalation of cattle excrement especially goats. There was an outbreak in Dutch goat farms. It presents with high fever, flu like symptoms and can cause hepatitis and endocarditis.

What is this disease ?

A

Q-fever

  • from goats, sheep, cattle
  • presents similar to brucellosis: fever, flu Sx - differences = pneumonia, hepatitis, endocarditis
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11
Q

What is the management of a patient that was bitten by a rabid looking dog in Thailand? (2)

A

Post exposure vaccination
AND
Immunoglobulin

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12
Q

A patient has been bitten by a rat and presents with fever, polyarthalgia and a purpurin rash.

What is the most likely diagnosis ?

A

Rat bite fever

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13
Q

A patient from the US has been bitten by a rat and presents with signs of ARDS and also has fever and myalgia. Dx?

A

Hantavirus pulmonary syndrome

  • The same type of virus found in SE Asia causes bleeding and renal failure instead of pulmonary failure
  • Key feature = resp failure
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14
Q

This disease is transmitted by rats, bats and ticks. It presents with fever, myalgia, flu-like symptoms and bleeding. This can be caused by Ebola…

What is the most likely disease ?

A

Viral haemorrhagic fever

  • Bleeding is key feature
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15
Q

A 35 year old patient presents with abdominal cramps and diarrhoea after a BBQ what is the most likely source?

A

chicken

  • This is most likely to be a case of campylobacter
  • get diarrhoea, blating, cramps
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16
Q

A 35 year old patient presents with fever after a bat bite. What potential infection is the most concerning?

A

Rabies virus (causes by Lyssa virus)

  • NB can come from dogs, cats, bats
17
Q

Patient died of encephalitis. Histology shows neural cells with Negri bodies. This finding is pathognomonic for ………..

A

Rabies!

Negri bodies are ribosomal inclusion bodies that make the cells look eosinophilic.

18
Q

features of campylobacter

A
  • poultry/ cattle
  • contaminated food esp. chicken
  • presentation: diarrhoea, bloating, cramps
  • inv: stool culture
  • man: supportive
19
Q

features of salmonella

A
  • poultry, reptiles/ amphibians
  • contaminated food, poor hygiene
  • presentation: diarrhoea, vomiting, fever
  • inv: stool
  • man: supportive, cipro, azithromycin
20
Q

features of bartonella henselae

A
  • kittens> cats
  • scratches, bikes, licks of wounds, fleas
  • causes - cat scratch disease (immunocompetent)
  • bacillary angiomatosis (immunocompromised)
21
Q

features of cat scratch disease

A
  • macule at site
  • pustular
  • regional adenopathy
  • systemic symptoms
  • inv: serology
  • man: erythromycin + doxy
22
Q

features of bacillary angiomatosis

A
  • skin papules, disseminated organ failure, bursting of vessels, can be fatal
  • inv: histopath, serology
  • man: erythromycin, doxy + rifampicin
23
Q

features of toxoplasmosis

A
  • cats, sheep
  • infected meat, faecal cont.
  • fever, adenopathy, still-birth, seizures, neuropathy
  • inv: serology
  • man: spiramycin, pyrimethamine + sulfadiazine
24
Q

features of brucellosis

A
  • cattle, goats
  • unpasteurised milk, undercooked meat
  • fever, back pain, orchitis, focal abscess (psoas, liver)
  • inv: blood/ pus culture, serology
  • man: doxy + gentamicin/rifampicin
25
Q

features of Q fever

A
  • cause = COXIELLA BURNETTI
  • goats, sheep, cattle
  • aerosolisation/ inhalation of secretions, waste, milk of infected animals
  • pres: fever, flu, pneumonia, hepatitis, endocarditis, focal abscesses
  • inv: serology
  • man: doxy
26
Q

features of rabies

A
  • lyssa virus
  • dogs, cats, bats
  • bites, scratches, contact with infected fluid
  • seizures, salivation, agitation, confusion, fever, headache
  • inv: serology, brain biopsy
  • man: IG, vaccine
27
Q

features of rat bite fever

A
  • streptobacillus moniliformis/ spirillum minus
  • rats
  • bites, contact with urine/ droppings
  • fevers, polyarthralgia, maculopapular progressing to purpuric rash, endocarditis
  • inv: joint fluid microscopy , blood culture
  • man: penecillins
28
Q

fetures of hentavirus pulmonary syndrome

A
  • deer mouse, white footed mouse, cotton rat, rice rat
  • contact with urine/droppings, aerosolisation
  • fever, myalgia, resp failure, bleeding + renal failure
  • inv: serology, PCR
  • man: supportive
29
Q

features of viral haemorrhagic fever

A
  • ebola, margurg,lass
  • contact with infected fluids
  • fever, myalgia, flu, bleeding
  • inv: serology, PCR
  • man: supportive
30
Q

Prognosis of rabies once Sx have started?

A

Near 100% mortality

31
Q

Name of virus that causes rabies

A

Lyssa Virus

32
Q

2 salmonella organism in humans

Does this need Tx?

A
  • S. typhi
  • S. paratyphi

Needs Tx of ABx (DON’T need for campylobacter): Ciprofloxacin, Azithromycin

33
Q

Mx of Cat scratch disease

A
  • Erythromycin
  • Doxycycline
34
Q

Mx of Bacilliary Angiomatosis

A
  • Erythromycin
  • Doxycycline
  • PLUS rifampicin
  • So first 2 is same as cat scratch disease, but add rifampicin for this one (NB both are from Bartonella henselae, which comes from cats)
35
Q

Mx of Toxoplasmosis

A
  • pregnant: Spiramycin
  • non-pregnant: Pyrimethamine + sulfadiazine
36
Q

First Ix to obtain in zoonoses

A

Blood culture