Microbio Exam 4 Flashcards
To study for Exam 4 of Micro
What does B19 Cause?
erythema infectiosum
What is the squamous epithelial growth that is either a wort or a verruca?
Papilloma
What variant of hepatitis needs assistance form HBV, and therefore cannot work if you’re vaccinated?
HDV
What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis E?
Abbreviation - HEV
Family Name - Hepeviridae
Nucleic Acid - RNA
Coating - Naked
Transmission - FO (Fecal Oral?)
What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis D?
Abbreviation - HDV
Family name - Unassigned (No family name)
Nucleic Acid - RNA
Coating - ENV
Transmission - blood/sex
What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis C?
Abbreviation - HCV
Family Name - Flaviviridae
Nucleic Acid - RNA
Coating - Envelope
Transmission - Blood/sex
What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis B?
Abbreviation - HBV
Family Name - Hepadnaviridae
Nucleic Acid - DNA
Coating- Envelope
Transmission- Blood/sex
What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis A?
Abbreviation - HAV
Family Name - Picornaviridae
Nucleic Acid - RNA
Coating - Naked
Transmission - FO
What causes a yellow tinge in skin and eyes
Jaundice
This is an inflammatory disease of liver cells that may result from infection by several viruses
Hepatitis
Malignancy of Epithelial cells is?
nasopharyngeal carcinoma
B cell malignancy is?
Burkitt Lymphoma
Infectious mononucleosis is dormant where?
B Cells
Sore throat, high fever, cervical lymph lymphadenopathy that develops after a 30-50 day incubation period is called?
Infectious mononucleosis
What is the primary infection of V2V
Varicella (chickenpox)
Humans as the only natural host, with infection transmitted by respiratory droplets and contact is called what?
Varicella - Zoster virus
What causes inflammation of the eye, latent virus that travels into the ophthalmic rather than the mandibular branch of trigeminal nerve?
Herpetic Keratitis
What is inflammation of the oral mucosa, especially in young children?
herpetic gingivostomatitis
What is the most common recurrent HSV-1 Infection?
Herpes labials
otherwise known as cold sores
What causes lesions on the genitalia, possibly oral - Occurs in the ages of 14-29 and can be spread without visible lesions?
HSV-2
What causes lesions on the oropharynx, cold sores, fever blisters, and usually only occurs in early childhood?
HSV-1
What was implicated in Kaposi sarcoma?
Herpesvirus 8 (KSHV)
Roseola is
Human herpesviruses 6 and 7
Cytomegalovirus (CMV) that infects the salivary glands and other viscera is
Herpesvirus 5
The Epstein-barr virus (EBV) associated with infection of the lymphoid tissue is called?
Herpesvirus 4
The varicella-zoster virus (V2V) Chickenpox and shingles
Herpesvirus 3
Fever blisters and genital infections caused by which herpes variant?
Herpes Simplex 1 and 2 (HSV)
What is the genus of virus that all show latency and cause recurrent infection?
Herpesviruses
What is the common transmission route for smallpox?
Respiratory
What is the first disease to be eliminated by vaccination?
Smallpox
What produces eruptive skin pustules that leave scars
Pox
What is it called when a virus crosses placenta and affects the fetus?
Teratogenic
What is a virus that causes cancer called
oncogenic
What are the enveloped RNA viruses (Note: There are a LOOOOOOOT of them)
ORTHOMYXOVIRIDAE
BUNYAVIRIDAE
ARENAVIRIDAE
PARAMYXOVIRIDAE
RHABDOVIRIDAE
FILOVIRIDAE
CORONAVIRIDAE
TOGAVIRIDAE
FLAVIVIRIDAE
RETROVIRIDAE
What are the naked RNA viruses? (Matching, there are 4)
Picornaviridae
Caliciviridae
Hepeviridae
Reoviridae
What are the naked DNA viruses?(there are 3)
Adenoviridae
Papillomaviridae
Parvoviridae
What are the envelope DNA viruses? (Only two)
Poxviridae
Herpesviridae
variola major last date and location was
75, bangladesh (south asia)
variola minor last date and location was
77, Somalia (East africa)
Edward Jenner is matched to
cowpox, smallpox
HPV-16 and HPV-18 was linked to what scientist
Harald zur Hausen
What virus causes hydrous fetalis
B19
Orthomyxoviridae is
h influenza virus
Bunyaviridae is
h hantavirus
Arenaviridae is
h lassa Fever virus
The 15 substypes that are the most important virulence factors that bind to host cells is called
Hemaglutnin
9 Subtypes - Hydrolyzes mucus and assists viral budding and release
neuraminidase
What is the difference between antigenic drift and antigenic shift
Drift is a minor change, Shift is a major change
What is the most virulent influenza
Influenzae A
What is the transmission by insects and tics
Bunyaviruses
American bunyavirus is a ________
hantavirus, Sin Nombre (no name)
Arenaviridae is
Lassa fever
Argentine hemorrhagic fever, Bolivian hemorrhagic fever etc
Closely associated with rodent host
Transmission through aerosols and contact
What are the enveloped nonsegmental ssRNA viruses
Paramyxoviruses
Rhabdoviruses
Coronaviruses
Togaviruses
Flaviviruses
Filoviruses
What are mumps caused by
Mumps virus
Measles is also known as
Red measles and/or rubeola
Rabies is transmitted via
rabid animal biting you
What do people look for in people who die from rabies?
Negri bodies
What disease causes Kolpik’s spots?
Measles
For the vector matching on exam 4, the answer is
Mosquito (professor admitted to fucking up and making all of the answers mosquito)
There’s a _______ for hepatitis B, but not for hepatitis C
vaccine
With symptoms very similar to infection with the chikungunya virus or dengue viruses, this cause birth defects
Zika viruses
What fever causes Jaundice?
Yellow fever
What fever is nicknamed “breakbone” fever, and makes you feel like your bones are breaking?
Dengue fever
Marburg (1967) is where what virus was discovered?
Marburg virus
Filoviridae virus marburg and ebola virus are
BSL-4
What are the five species of ebolavirus?
Zaire
Sudan
Bundibugyo
Tai forest
Reston
HIV classification
Family - Retroviridae
Genus - Lentivirus
Species - Human immunodeficiency virus
Types - HIV-1 (worldwide) and HIV-2 (only small parts of west Africa). HIV-2 is less transmissible and reduced likelihood to progress to AIDs.
What are the three enzymes of HIV
Reverse transcriptase
Integrase
Protease
What is the virion structure of HIV?
Enveloped RNA
Icosahedral
72 spikes
What are the transmissions of HIV
Sex
Blood
Perinatal transmission
- Placenta 25%
- Birth 50%
- Breast milk 25%
Parentheral
What is the pathogenesis of HIV?
Helper T cells
Macrophages
Monocytes
B cells
Microglial brain cells
Intestinal cells
Suppression of cell-mediated immunity
Opportunistic infection
What are the 3 stages of infection for HIV?
ACUTE - 2-4 weeks, mononucleosis like symptoms
Latent - 7 to 11 year, asymptomatic
Late - Decrease in CD4 cells to below 400/ul
AIDs is when CD4 cells fall below to 200/ul
What does the treatment for HIV target?
Targets viral replication
What are the nonenveloped nonsegmental ssRNA viruses(there are 4)
Picornaviruses
Enterovirus
Rhinovirus
Cardiovirus
What is the acute enteroviral infection of the spinal cord that can cause neuromuscular paralysis (although it is quite rare)
Poliomyelitis
Hepatitis A is transmitted how?
Fecal-Oral
Norwalk agent best known, believed to cause 1/3rd of all viral gastroenteritis cases and is transmitted by fecal-oral is called?
Caliciviruses
What unusual double stranded RNA genome is transmitted oral-fecal transmission, and is the primary viral cause of mortality and morbidity resulting from diarrhea in infants and children?
Rotavirus
What are the proteinaceous infetious particles that are highly resistant to multiple forms of treatment?
Prions
Who was the scientist that created the smallpox vaccination (also potentially child abuser)
Edward Jenner
Who won the nobel piece prize for discovering the link between HPV and cancer?
Harald Zur Hausen
Clara maass is
The only woman volunteer who died after experimental mosquito exposure and developed severe yellow fever. Her death led to a public outcry that ended human experimentation.
Mikhail Surenovich Balayan is
Russian virologist who incubated feces in yogurt and ate it like a weirdo, incubating HEV in his body.
Who discovered prions
Stanley B. Prusiner
HHV-1 Is ______ and causes _______
Herpes Simplex 1, usually lesions on the oropharynx, cold sores, fever blisters. Occurs in early childhood.
HHV-2 is ________ and causes _______
Herpes Simplex 2 , Lesions on the genitalia, possibly oral.
Occurs in ages 14-29, can be spread without visible lesions.
HHV-3 Is ____ and causes ______
Varicella zoster - Causes chickenpox and can be reactivated as shingles.
HHV-4 Is ______ and causes ______
Epstein-Barr, causes mono/kissing disease. Transmitted through direct, oral contact and contamination with saliva.
HHV-5 is _____ and causes _____
Cytomegalovirus - Produces giant cells with nuclear and cytoplasmic inclusions. Transmitted through saliva, respiratory mucus, milk, urine, semen, cervical secretions etc. Causes fever, fatigue.
HHV-8 Is _______ and causes ______
Kaposi’s sarcoma-Associated virus (KSHV), linked with common tumor of AIDs patients; also may be involved in multiple myeloma
(Matching) Name all the Env DNA. (there’s a lot, dont get discouraged missing some)
POXVIRIDAE
*smallpox
*cowpox
*monkeypox
*Molluscum contagiosum
HERPESVIRIDAE
*HHV-1 through 8
HEPADANIVIRIDAE
*HBV
(Matching) Name all the naked DNA
ADENOVIRIDAE
PAPILLOMAVIRIDAE
*HPV 1-4
*HPV6, 11
*HPV 16, 18
PARVOVIRIDAE
*B19
(Matching) Name all the naked RNA.
PICORNAVIRIDAE
*Polio
*HAV
*Rhinovirus
CALCIVIRIDAE
*Norovirus
HEPEVIRIDAE
*HEV
REOVIRIDAE
RotaVirus
(Matching) Name all the Enveloped RNA viruses
ORTHOMYXOVIRIDAE
Influenza A, B, C
BUNYAVIRIDAE
Hantavirus
ARENAVIRIDAE
*lassa fever
PARAMYXOVIRIDAE
*parainfluenza
*Mumps
*Measles
*RSV
RHABDOVIRIDAE
*Rabies
FILOVIRIDAE
*Marburg
*Ebola
CORONAVIRIDAE
Coronavirus
SARS
MERS*
TOGAVIRIDAE
*Rubella
FLAVIVIRIDAE
*HCV
*Yellow Fever
*Dengue Fever
*west Nile
*Zika
RETROVIRIDAE
*HIV
A constant mutation is called ________ that gradually changes their amino acid composition
Antigenic Drift
one of the genes or RNA strands is substituted with a gene or strand from another influenza virus from a different animal host is called _________
Antigenic Shift
Where do pox viruses replicate?
In the Cytoplasm
Most common Route for smallpox is
Respiratory
What is the much more common poxvirus that causes a skin disease?
molluscum contagiosum
What’s the only available vaccine for HPV in the united states?
Gardisal 9
Harald Zur hausen is matched with which HPV?
HPV-16 and 18
Parainfluenza is transmitted by
Respiratory
What is the self-limited illness associated with painful swelling of parotid salivary glands?
Epidemic parotitis
What are the oral lesions associated with measles?
Koplik’s Spots
What is the initial testing for HIV?
ELISA (Enzyme linked immunoabsorbant assay)
What is the confirmatory testing for HIV?
Western blot
transmissible spongiform encephalopathies (TSEs) in humans, Creutzfeldt-Jakob disease (CJD) are the two _______ diseases
Prions
Prion is short for
Protein Infection
Who is the scientist that won a Nobel prize for discovering prions?
Stanley B Prusiner.
list all the diseases transmitted from sex
Hepadnaviridae (HBV/Hepatitis B)
Flaviviridae (HCV/Hepatitis C)
HDV (Hepatitis D)
HIV/Retroviridae
HHV-2
Molluscum Contagiosum
List all the diseases transmitted from vectors
Flaviviridae
-West Nile virus
-yellow fever virus
-Dengue fever virus
-Zika virus
List all the diseases transmitted from Fecal/Oral
-Picornaviridae (HAV/Hepatitis A)
-Hepeviridae (HEV/Hepatitis E)
-Adenoviridae (gastroenteritis)
-Picornaviridae (HAV, poliovirus)
List all the diseases transmitted from respiratory
Smallpox (Poxviridae)
Chickenpox (HHV-3)
Adenoviridae (respiratory infections)
Parvoviridae
Coronaviridae
Togaviridae
Paramyxoviridae (parainfluenza, mumps, measles, pneumonia and bronchitis)
Orthomyxoviridae
Bunyaviridae
List all the disease transmitted from ingestion
Any prion disease