Micro U2 L1 pt 2. Flashcards
How does transmission of most parasitic infections spread?
mosquitos, ticks, specific flies, other arthropods
What is human to most parasitic infections?
intermediate host. sexual reproduction occurs in vector associated with transmission of agent
Plasmodium
protozoan parasite - malaria
Which area of the world is most affected by malaria and why?
africa - very efficient mosquito (anophele gambiae complex); predominant parasite species is plasmodium falciparum; warm weather = year round
What transmits malaria?
anopheles mosquitos - usually by female mosquitos
What are the four parasite species that cause malaria in humans?
plamodium falciparum, vivax, malariae, ovale
Plasmodium falciparum
most fatal outcomes - sub saharan africa, SE asia, S america
Plasmodium vivax
most common, seen in US - NOT seen in sub saharan africa
Plasmodium malariae
all malarious areas, but spotty
Plasmodium ovale
tropical areas - africa; SE asia, S america
What are the clinical symptoms of malaria due to?
schizont rupture and destruction of erythrocytes
What are the prodromal symptoms of malaria?
fever, chills, headaches, diaphoresis
What are malarial paroxysms?
febrile attacks following the prodromal symptoms - exhibit periodicities (24 hrs for vivax, ovale, falciparum and 72 hr for malariae)
What are natural protections against malaria?
- hg C, S (sickle cell) 2. Duffy antigen - lack this = low incidence 3. thalassemia
What are the stages of the malaria paroxysm?
- cold stage (lysis of RBC) - intense cold feeling, shivering, 15-20 min 2. hot stage - due to circulating and innate immune response - intense heat, dry burning skin, throbbing headache, 2-6 hr 3. sweating stage due to infection of additional erythrocytes and immune system shutting off - profuse sweating, declining temp, exhausted and weak, 2-4 hr
What are the major complications of severe malaria?
cerebral malaria, pulmonary edema, acute renal failure, severe anemia, bleeding
What are the most common metabolic complications of malaria?
acidosis and hypoglycemia
PfEMP-1 antigen
on 100% of RBCs