Micro toxins Flashcards
Inactivates elongation factor 2 (EF2)
Diptheria toxin and exotoxin A (from pseudomonas)
MOA of Shigella toxin and shiga-like toxin (EHEC)
Inactivate 60s ribosome by removing adenine from rRNA
2 toxins from ETEC
Heat labile (LT) and heat-stable (ST) toxins
MOA of heat-labile toxin (LT) from ETEC
overactivates adenylate cyclase to increase cAMP; leads to increase Cl- secretion in the gut and H2O efflux
MOA of heat-stable (ST) from ETEC
Overactivate guanylate cyclase to increase cGMP levels; leads to decreased resorption of NaCl from the gut (and thus decreased H2) resorption
Diptheria toxin and Toxin A from pseudomonas are what kind of toxin
A-B toxin; B is for Binding to the host cell, A is the Active component
Bacillus anthracis toxin
Edema factor
MOA of edema factor in anthrax
Mimics adenylate cyclase enzyme to increase cAMP
Cholera toxin MOA
Overactivate adenylate cyclase to increase cAMP by permanently activating Gs
Leads to Cl- secretion in the gut and H2O efflux
Pertussis toxin MOA
Overactivate adenylate cyclase to incease cAMP by disabling Gi
Toxins that cleave the SNARE protein required for neurotransmitter release
Tetanospasmin and botulinum toxin
If tetanus and botulinum toxins both have same MOA, why do the produced different effects
Tetanospasmin acts on inhibitory NTs (GABA and glycine) while botox prevents excitatory ACh release
Clostridium perfringens toxin
Alpha toxin (aka lecithinase)
MOA of alpha toxin from C. perfringens
Phospholipase that degrades tissues and cell membranes
Streptolysin O MOA
Degrades cell membrane (responsible for the B-hemolysis of Strep pyogenes)
Superantigen from S. aureus
Toxic shock syndrome Toxin (TSST-1)
MOA of TSST-1
Bind MHC II and TCR outside of the binding site to cause non-specific release of IFN-gamma and IL-2. This leads to shock
Superantigen in s. pyogenes
Bind MHC II and TCR outside of the binding site to cause non-specific release of IFN-gamma and IL-2. This leads to shock.
C. dif toxin
Toxin A and B
MOA of toxin A in C. dif
Binds to the brush border of the gut
MOA of toxin B in C. dif
Destroys cytoskeletal structure of enterocytes; is what cause the pseudomembranous colits
TB virulence factor
Cord factor
MOA of cord factor
Inhibits macrophage release and induce release of TNF-alpha
S. aureus virulence factor
Protein A
MOA of protein A on S. aureus
Binds to IgG at the Fc region to prevent compliment fixation and phagocytosis
