Micro - POSITIVE Single Stranded RNA Flashcards
What is the smallest of all RNA viruses?
Picornavirus
Is Picornavirus group double or single stranded?
Single
Is Piconavirus positive or negative?
Positive
What is the shape of Picornavirus group capsid?
Icosahedral
Does Picornavirus group have an envelope?
NO
Is Picornavirus replicated in the nucleus or cytoplasm?
Cytoplasm
Does Picornavirs use RDRP?
YES
Does Picornavirus group carry their RDRP?
NO
What are the two subcategories of Picornavirus?
- Rhinoviruses (nose - respiratory)
- Enteroviruses (intestine)
Which subcatagory virus of Picornavirus prefers cooler temp, can’t tolerate acid pH, is common cold virus and has over 150 serological types?
Rhinovirus
What subcatagory virus of Picornavirus prefers hotter temp and can tolerate acid pH?
Enterovirus
What are the major examples of Enterovirus?
- Hepatitis A virus
- Polio virus
- Coxsackie A virus
What specific virus of Enterovirus group is a causative agent of hepatitis A, spread fecal/oral and are common in day care and resaurants
Hepatitis A virus (Enterovirus 72)
What specific virus of Enterovirus group is a causative agent of polio, spread fecal/oral and replicates in nerve cells?
Polio virus
What are the two vaccines to the specific virsu Polio virus?
- Salk - Inactive
- Sabine - Active
Which specific virus of Enterovirus group has symptoms of fever, sore throat, rash that progress to blisters mainly on the hands, foot and mount?
Coxsackie A Virus (A16)
What is unique about Picornavirus group?
Smallest of RNA viruses
PICO = SMALL
Is Togavirus group positive or negative?
Positive
Is Togavirus group double or single stranded RNA?
Single
What is the shape of the Togavirus group capsid?
Icosahedral
Does the Togavirus group have a capsid?
YES - from the plasma membrane
Do the Togavirus group replicate in the nucleus or cytoplasm?
Cytoplasm
Does Togavirus group use RDRP?
YES
Does Togavirus group carry their RDRP?
NO
What are the two subcatagories of Togavirus group?
- Alphavirus
- Flavivirus
What are the specific viruses that fall under Flavivirus group?
- Hepatitis C virus
- Arthropod borne flaviviruses
What is the specific virus of the Flavivirus group that is a causative agent of hepatitis C, spread via STD or blood/blood products and implicated in chronic liver ds.?
Hepatitis C virus
Arthropod Borne Falviviruses
Arthorpod borne Alphaviruses
What specific virus of Togavirus group is known as “german measles, part of TORCH and is only harmful to a fetus?
Rubella virus
What persistent slow viral infection do you see with Rubella?
Progressive Rubella Panencephalitis
with this you see Subacute Sclerosing Panencephalitis (SSPE)
What is unique about Togavirus group?
Nothing for the group
BUT know what is unique about the specific viruses that fall under it (i.e. spread, symptoms, who is affected etc.)
Is Coronavirus group positive or negative?
Positive
Is Coronavirus group double or single stranded RNA?
Single
What is the shape of the Coronavirus group capsid?
Helical
Does the Coronavirus group have a envelope?
YES - from cytoplasmic vessels
Does the Coronavirus group replicate in the nucleus or cytoplasm?
Cytoplasm
Does Coronavirus group use RDRP?
YES
Does Coronavirus group carry their RDRP?
NO
What special charateristic does Coronavirus group have?
outter covering of pedal like projections that resemble fring (these are NOT spikes)

What is SARS
Severe Acute Respiratory Syndrom
What is the causative agent of SARS?
Unspecified Cornonavirus
What is unique about Coronavirus group?
- Pedal like projections
- Helical capsid
Is Calicivirus group positive or negative?
Positive
Is Calicivirus double or single stranded?
Single
What is the shape of Calicivirus group capsid?
Icosahedral - cup like indentations “wine glass”

Does the Calicivirus have an envelope?
NO
Does Calicivirus replicate in the nucleus or cytoplasm?
Cytoplasm
Does Calicivirus use RDRP?
YES
Does Calicivirus group carry their RDRP?
NO
What is the specific virus that falls under Calicivirus group?
Norovirus “cruise ship” virus
what specific virus of Calicivirus group causes mild diarrhea, flu symptoms, spread through fecal/oral and is the cause of 1/3 of all viral gastrointestinal ds.?
Norovirus
What is unique about Calicivirus group?
Nothing for the group
BUT know what is unique for the specific virus (i.e. spread, nickname, symptoms etc.)
Is Oncornavirus group positive or negative?
Positive
Is Oncornavirus double or single stranded?
Single
What is the shape of Oncornavirus group capsid?
Icosahedral
Does Oncornavirus group have an envelope?
Yes - from plasma membrane
Does Oncornavirus replicate in the nucleus or cytoplasm?
NUCLEUS
Does Oncornavirus use RDRP?
NO
- They use RDDP to change from RNA to DNA
- Then use DDDP to turn in to the ds. DNA
- Then once they have turned to ds. DNA they insert into host choromosome and stay latent
Does Oncornavirus carry RDRP?
NO - b/c they use RDDP
They carry RDDP
What is a specific virus of Oncornavirus group?
HIV - Human immunodeficiency virus
What specific virus of Oncornavirus group is sexually transmitted and attacks CD4 antigen on helper T-cells?
HIV
HIV uses RDDP and RDDP does not “proof read” so mistakes are made. What is the signifigance of those mistakes?
- May turn RNA to DNA but it’s not very usefull
- May allow virus to enter your chromosomes but as long as it remains latent, you won’t encouter problems. Problems only occur when the virus come back out of the chromosome and picks up where replication left off
What is unique about Oncornovirus group?
- Replicates in the NUCLEUS
- Carries RDDP (instead of RDRP)