MICRO EXAM 3

Question 1

Mycobacteria family

Answer 1

• slim bacilli
• acid fast
• mycolic acid & lipoarabinomannan

Question 2

Mycobacteria tuberculosis

Answer 2

• niacin
• person-to-person via inhalation of respiratory droplets
• middle & lower lobes
• surface proteins (ESAT-6)
• alveolar macrophage receptors (complement receptors CR1, CR2, CR4)
• urease
• antioxidants
• TNF, IL-12, INF gamma
• TH1 response
• CD8+ cytotoxic T cells
• DTH response
• tubercles/granulomas
• caseous lesions (cheese-like consistency)
• Gohn complex
• under hypoxic conditions -> latency genes activated
• resuscitation-promoting factor
• dry cough -> sputum
• cryptic disseminated tb
• Mantoux tuberculin skin test, LJ medium (brown), IGRA (IFN), acid fast/fluorescent staining, PCR (esp for MDR)
• RIPE