Micro Flashcards
mech of tetracycline
inhibits tRNA binding to A site during protein translation
mech of erythromycin/clindamycin
block protein elongation (5’-3’) in translation
mech of streptomycin
binds 30s ribosome changing its conformation and preventing it from binding 50s ribosome and forming the initiation complex for protein translation
mech of chloramphenicol
blocks peptidyl transferase from moving AA from A to E site and forming peptide bonds during protein synthesis
megaloblastic anemia + high orotic aciduria
orotic acidemua
defect in pyrimidine synthesis
treat with uridine supplementation
defect in orotate phosphoribyl tranferasse and OMP decarboxylase
Parkin, Pink-1, DJ 1
mt leading to defect in ubiquitin genes-do not get effective destruction of misfolded proteins and therefore get cytosol accumualtion of bad proteins in the cell
aldolase B def
intolerance to fructose
get buildup of fructose 1 phosphate
tx: no fructose
pompes disease
alpha glucasidase deificiency
-used in glycogenolysis
hypontia, cardiomyopathy
galastosemia
galactose 1 phosphate uridyl transferase deficiency, AR, hepatomegaly, ftt, jaundice, feeding intolerance soon with breastfeeding
hereditary fructose intolerance
-aldolase B deficiency
severe life threatening form of fructose intolerance, non functional fructokinase enzyme with inability to metabolize fructose get severe hypoglycemia 20-30min after ingestion of fructose (due to accumulation of fructose 1 phosphate and depletion of inorganic phosphate)
PKU
defect in phenylalanine hydroxylase
acyclovir
used to treat herpes simplex (+ tzanck) incorporates itself into viral DNA (acyclovir monophos to triphos) and ends Viral DNA synthesis, does not affect nml cells because has much less affiniity and is not phosphrylated as much in normal cells
