Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Tech 4 > Mice- MUS MUSCULUS > Flashcards

Mice- MUS MUSCULUS Flashcards

1
Q

4 types of genetic strains

A
  1. Outbred
  2. Inbred
  3. Congenic
  4. Transgenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Results from random mating to achieve genetic variations; genetically heterogeneous and are used to represent diversity of the human population

A

Outbred Strain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Are the result of brother/sister/father/daughter/mother/son matings for a min of 20 consecutive generations

A

Inbred Strain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

BALB/c Strain-

C57BL-

A

Albino

Black

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Animals genetically different at one particular locus

A

Congenic Strains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Are the result of microinjection of DNA into mouse eggs for the production of very specific dz models

A

Transgenic Strains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

5 eccological types

A
  1. Germ free or axenic
  2. Gnotobiotic
  3. Specific pathogen free
  4. Conventional
  5. Sentinel animals
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Free of all detectable microflora; mice housed in filtered cages and on specific diets

A

Germ free or axenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

associated known mircroflora

A

Gnotobiotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

free of specific pathogens

A

Specific pathogen free

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

animals with undefined microflora and housed with no special precautions (dont know health status)

A

Conventional

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

healthy animal placed in a room with other animals as a means of detecting the presence of dz

A

Sentinel animals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

7 uses for mice

A
  1. Short life span
  2. Short gestation
  3. Large litter sizes
  4. Great genetic diversity
  5. Inexpensive
  6. Easy to maintain
  7. Make good models for toxicity tests
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Shoe box caging holds __females & __ males

A

5;4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Behavior of mice:

A

Nocturnal but easily awakened
Social animals
Handle gently/continence
Male mice have more tendency to fight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When a dominant mouse in a group will remove the facial hair from all other mice in the cage; source of stress

A

Barbering

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mice have a ______ developed sense of smell and acutely ________ sense of hearing

A

highly; sensitive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Life span of mice is _______ years

A

1-3 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Body temp of mice is ________degrees F

A

98-101 degrees F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

HR of mice is ________bmp

RR of mice is ________rpm

A

300-750bpm

70-120rpm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Gestation period for mice is ________days

A

19-21 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Weaning age of mice is ________days

A

21-28 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

When tail tissue/.muscle breaks off the bone

A

degloving injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Rodent dental formula:

A

2(I 1/1, C 0/0, P 0/0, M 3/3)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Meaning they continuously grow throughout their lives
open rooted
26
The incisors change color with _____
age
27
Incisors are ______, meaning open rooted
hypsodontic
28
5 paired mammary glands, ____ throacic and ____ abdominal
3; 2
29
Mice DO NOT have _____ glands
sweat
30
2 main purposes of the tail
balance | thermoregulation
31
Males have 2 distinct features
open inguinal canals | os penis
32
Lacrimal glands located behind the eye is what kind of gland?
Harderian
33
Medical term for red tears:
Chromodacroyhea
34
The Harderian gland secretes what?
porphyrin (red tears)
35
Distance between the anus and genitals
Anogenital distance
36
The anogenital distance is longer in _______
males
37
Their polyestrus cycle is ____ days
4-5
38
Postpartum estrus is ____ hours after parturition
24
39
Cage should be cleaned and food/water should be placed ___ week prior to parturition
1
40
Baby mice and rats are called ______
pups
41
They typically have hair at ____ week of age and their eyes open at about ___ weeks of age
1; 2
42
When a group of female mice are exposed to a male, the majority will be in estrous by the ____ night & this is also called what?
third; Whitten Effect
43
This effect is when a pregnant female will return to estrus when exposed to a strange male
Bruce Effect
44
Within ___ hours of copulation the female will release a hormone, get an abortion, and then get impregnated by a new male. Only happens once
48
45
This effect is when a female is bred during postpartum estrus, and she will have an extended gestation
Lee Boot Effect
46
The Lee Boot Effect is _________ days
35-40
47
Their digestive system is divided into 2 parts:
Glandular | Aglandular
48
Recycles B vitamins made by colonic bacteria
Coprophagy
49
Mice are unable to:
regurgitate and vomit
50
Brown fat is located between __________ and around _________
shoulders; kidneys
51
Rodents have a large _______
cecum
52
Brown fat stores energy in the form of
glycogen
53
Cage card should include:
``` PI Contact info Strain (Balbc) Date of birth Bio hazard info* # of mice in the cage* ```
54
5 types of identification methods:
``` Ear notching/punching Cage cards Ink tail markings Microchipping Ear tag ```
55
2 types of sampling of rodents blood:
Gastric gavage | Blood sampling
56
Rodents must are usually awake for which 3 routes:
saphenous lateral tail vein submandibular
57
Rodents MUST be sedated for which 2 routes:
``` Retro-orbital sinus Cardiac puncture (euthanized after) ```
58
Total Body Volume= ____% of body weight in grams
7
59
Low dose: | High dose:
10% | 15%
60
4 types of injections on rodents:
IV IM IP SQ
61
___-____g needles, tuberculin syringes & alcohol swabs are for ___ injections
23-25; IV
62
0.05ml are in mice by which injection
IM
63
____gauge needle/ tuberculin syringe is used in IM
25
64
___ injections allows for larger volumes
IP
65
Animals head for IP should tilted _____ than the rest of the body so the abdominal organs fall forward
lower
66
The needle for IP should be inserted bevel up at a ____ degree angle
20
67
The syringe should be ________ to ensure no organs have been punctured
aspirated
68
SQ injections give _____ ml to mice
2-3
69
Name the max dosing amount for each injection: IP/SQ/IM/IV/PO
``` IP=2.0ml SQ= 2.5ml IM=0.05ml IV=0.125ml PO= 1.0ml ```
70
Some signs of pain rodents show:
``` weight loss, sunken eyes, change in urine, fecal output hunched posture lethargy, depression, isolation change in locomotion ruffled hair coat ocular/nasal discharge change in behavior selfmutilation analgesics may be given ```
71
2 common pain meds given to rodents:
butophanol | buprenex (buprenorphine)
72
This virus is a respiratory dz (morbidity is 100%), can be combined with bacterial infection, seen in young weanlings/stressed mice, rough hair coat, hunched posture, dyspnea, chattering,
Sendai Virus
73
Most common health condition, causes upper respiratory dz (rhinitis, head tilt),both treated with antibiotics in water
Mycoplasma pulmonis, Pasteurella Pneumotropica
74
Corona Virus Common in iummunosuppressed Dehydration, wt loss, d+, sudden death Need to control in colony
Mouse Hepatitis Virus (MHV)
75
Corona virus similar to MHV Causes swelling of lymph nodes/hardarian gland (behind eyes) Animal may have ocular lesions & become photophobic Supportive therapy May also see red tears
Sialodacryodenitis
76
Wild mice Passed by arthropods Hunched posture, photophobia, convulsions Zoonotic by bite wounds, infected tissure/urine
Lymphocytic Choriomeningitis (LCM)
77
Rotavirus Miss less than 2 weeks of age Soft yellow feces Filter top cages, cull affected litters
Epizootic D+ of infant mice (EDIM)
78
Clostridium or bacilus piliformis- bacterium form spores wt loss, rough hair coat, listlessness, sudden death Due to poor housing conditions
Tyzzers Dz
79
2 main types of Mouse Parvoviruses
MPV type 1 | Mouse Minute Virus (MMV)
80
Targets intestinal/lymphoid tissue (subclinical) | Causes immune dysfunction
Mouse Parvoviruses
81
2 Endoparasites/Ectoparasites:
pinworms | mites
82
Aspicularis tetraptera, Syphacia obvelata Fecal float, cellphance tape Anthelminitic=Ivermectin
Pinworms
83
Myobia musculi, Myocoptes musculinus Alopecia, pruritus, dermatitis Pluck fur, scrape skin Ivermectin/Mitaban
Mites
84
2 Misc health conditions:
moist dermatitis | Neoplasia
85
Moist dermatitis= | Neoplasia=
wet housing condition | mammary tumors
86
Nutrition of rodents:
Omnivores pelleted diets are preferable to see mixtures Food should be in crocks or hoppers Fresh water
87
3 ways to euthanize rodents:
1. Overdose of isoflurance, halothane or sevoflurance (last resort)(inhalants) 2. Overdose of injectable barbiturate(euthanasia solution)(clinical setting)(IP) 3. Overdose of CO2 (research setting)
88
Overdose of CO2 will not be successful in mice under ____ weeks of age; resistant to hypoxia
16
89
Never _________ CO2 chamber for euthanasia
preload

Tech 4 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions