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Tech 4 > Mice- MUS MUSCULUS > Flashcards

Mice- MUS MUSCULUS Flashcards

1
Q

4 types of genetic strains

A
  1. Outbred
  2. Inbred
  3. Congenic
  4. Transgenic
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2
Q

Results from random mating to achieve genetic variations; genetically heterogeneous and are used to represent diversity of the human population

A

Outbred Strain

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3
Q

Are the result of brother/sister/father/daughter/mother/son matings for a min of 20 consecutive generations

A

Inbred Strain

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4
Q

BALB/c Strain-

C57BL-

A

Albino

Black

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5
Q

Animals genetically different at one particular locus

A

Congenic Strains

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6
Q

Are the result of microinjection of DNA into mouse eggs for the production of very specific dz models

A

Transgenic Strains

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7
Q

5 eccological types

A
  1. Germ free or axenic
  2. Gnotobiotic
  3. Specific pathogen free
  4. Conventional
  5. Sentinel animals
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8
Q

Free of all detectable microflora; mice housed in filtered cages and on specific diets

A

Germ free or axenic

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9
Q

associated known mircroflora

A

Gnotobiotic

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10
Q

free of specific pathogens

A

Specific pathogen free

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11
Q

animals with undefined microflora and housed with no special precautions (dont know health status)

A

Conventional

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12
Q

healthy animal placed in a room with other animals as a means of detecting the presence of dz

A

Sentinel animals

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13
Q

7 uses for mice

A
  1. Short life span
  2. Short gestation
  3. Large litter sizes
  4. Great genetic diversity
  5. Inexpensive
  6. Easy to maintain
  7. Make good models for toxicity tests
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14
Q

Shoe box caging holds __females & __ males

A

5;4

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15
Q

Behavior of mice:

A

Nocturnal but easily awakened
Social animals
Handle gently/continence
Male mice have more tendency to fight

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16
Q

When a dominant mouse in a group will remove the facial hair from all other mice in the cage; source of stress

A

Barbering

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17
Q

Mice have a ______ developed sense of smell and acutely ________ sense of hearing

A

highly; sensitive

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18
Q

Life span of mice is _______ years

A

1-3 years

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19
Q

Body temp of mice is ________degrees F

A

98-101 degrees F

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20
Q

HR of mice is ________bmp

RR of mice is ________rpm

A

300-750bpm

70-120rpm

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21
Q

Gestation period for mice is ________days

A

19-21 days

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22
Q

Weaning age of mice is ________days

A

21-28 days

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23
Q

When tail tissue/.muscle breaks off the bone

A

degloving injury

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24
Q

Rodent dental formula:

A

2(I 1/1, C 0/0, P 0/0, M 3/3)

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25
Q

Meaning they continuously grow throughout their lives

A

open rooted

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26
Q

The incisors change color with _____

A

age

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27
Q

Incisors are ______, meaning open rooted

A

hypsodontic

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28
Q

5 paired mammary glands, ____ throacic and ____ abdominal

A

3; 2

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29
Q

Mice DO NOT have _____ glands

A

sweat

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30
Q

2 main purposes of the tail

A

balance

thermoregulation

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31
Q

Males have 2 distinct features

A

open inguinal canals

os penis

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32
Q

Lacrimal glands located behind the eye is what kind of gland?

A

Harderian

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33
Q

Medical term for red tears:

A

Chromodacroyhea

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34
Q

The Harderian gland secretes what?

A

porphyrin (red tears)

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35
Q

Distance between the anus and genitals

A

Anogenital distance

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36
Q

The anogenital distance is longer in _______

A

males

37
Q

Their polyestrus cycle is ____ days

A

4-5

38
Q

Postpartum estrus is ____ hours after parturition

A

24

39
Q

Cage should be cleaned and food/water should be placed ___ week prior to parturition

A

1

40
Q

Baby mice and rats are called ______

A

pups

41
Q

They typically have hair at ____ week of age and their eyes open at about ___ weeks of age

A

1; 2

42
Q

When a group of female mice are exposed to a male, the majority will be in estrous by the ____ night & this is also called what?

A

third; Whitten Effect

43
Q

This effect is when a pregnant female will return to estrus when exposed to a strange male

A

Bruce Effect

44
Q

Within ___ hours of copulation the female will release a hormone, get an abortion, and then get impregnated by a new male. Only happens once

A

48

45
Q

This effect is when a female is bred during postpartum estrus, and she will have an extended gestation

A

Lee Boot Effect

46
Q

The Lee Boot Effect is _________ days

A

35-40

47
Q

Their digestive system is divided into 2 parts:

A

Glandular

Aglandular

48
Q

Recycles B vitamins made by colonic bacteria

A

Coprophagy

49
Q

Mice are unable to:

A

regurgitate and vomit

50
Q

Brown fat is located between __________ and around _________

A

shoulders; kidneys

51
Q

Rodents have a large _______

A

cecum

52
Q

Brown fat stores energy in the form of

A

glycogen

53
Q

Cage card should include:

A 
PI 
Contact info 
Strain (Balbc)
Date of birth 
Bio hazard info*
# of mice in the cage*
54
Q

5 types of identification methods:

A 
Ear notching/punching
Cage cards
Ink tail markings 
Microchipping
Ear tag
55
Q

2 types of sampling of rodents blood:

A

Gastric gavage

Blood sampling

56
Q

Rodents must are usually awake for which 3 routes:

A

saphenous
lateral tail vein
submandibular

57
Q

Rodents MUST be sedated for which 2 routes:

A 
Retro-orbital sinus 
Cardiac puncture (euthanized after)
58
Q

Total Body Volume= ____% of body weight in grams

A

7

59
Q

Low dose:

High dose:

A

10%

15%

60
Q

4 types of injections on rodents:

A

IV
IM
IP
SQ

61
Q

___-____g needles, tuberculin syringes & alcohol swabs are for ___ injections

A

23-25; IV

62
Q

0.05ml are in mice by which injection

A

IM

63
Q

____gauge needle/ tuberculin syringe is used in IM

A

25

64
Q

___ injections allows for larger volumes

A

IP

65
Q

Animals head for IP should tilted _____ than the rest of the body so the abdominal organs fall forward

A

lower

66
Q

The needle for IP should be inserted bevel up at a ____ degree angle

A

20

67
Q

The syringe should be ________ to ensure no organs have been punctured

A

aspirated

68
Q

SQ injections give _____ ml to mice

A

2-3

69
Q

Name the max dosing amount for each injection: IP/SQ/IM/IV/PO

A 
IP=2.0ml
SQ= 2.5ml
IM=0.05ml
IV=0.125ml
PO= 1.0ml
70
Q

Some signs of pain rodents show:

A 
weight loss, sunken eyes, change in urine, fecal output
hunched posture
lethargy, depression, isolation
change in locomotion
ruffled hair coat
ocular/nasal discharge
change in behavior
selfmutilation
analgesics may be given
71
Q

2 common pain meds given to rodents:

A

butophanol

buprenex (buprenorphine)

72
Q

This virus is a respiratory dz (morbidity is 100%), can be combined with bacterial infection, seen in young weanlings/stressed mice, rough hair coat, hunched posture, dyspnea, chattering,

A

Sendai Virus

73
Q

Most common health condition, causes upper respiratory dz (rhinitis, head tilt),both treated with antibiotics in water

A

Mycoplasma pulmonis, Pasteurella Pneumotropica

74
Q

Corona Virus
Common in iummunosuppressed
Dehydration, wt loss, d+, sudden death
Need to control in colony

A

Mouse Hepatitis Virus (MHV)

75
Q

Corona virus similar to MHV
Causes swelling of lymph nodes/hardarian gland (behind eyes)
Animal may have ocular lesions & become photophobic
Supportive therapy
May also see red tears

A

Sialodacryodenitis

76
Q

Wild mice
Passed by arthropods
Hunched posture, photophobia, convulsions
Zoonotic by bite wounds, infected tissure/urine

A

Lymphocytic Choriomeningitis (LCM)

77
Q

Rotavirus
Miss less than 2 weeks of age
Soft yellow feces
Filter top cages, cull affected litters

A

Epizootic D+ of infant mice (EDIM)

78
Q

Clostridium or bacilus piliformis- bacterium form spores
wt loss, rough hair coat, listlessness, sudden death
Due to poor housing conditions

A

Tyzzers Dz

79
Q

2 main types of Mouse Parvoviruses

A

MPV type 1

Mouse Minute Virus (MMV)

80
Q

Targets intestinal/lymphoid tissue (subclinical)

Causes immune dysfunction

A

Mouse Parvoviruses

81
Q

2 Endoparasites/Ectoparasites:

A

pinworms

mites

82
Q

Aspicularis tetraptera, Syphacia obvelata
Fecal float, cellphance tape
Anthelminitic=Ivermectin

A

Pinworms

83
Q

Myobia musculi, Myocoptes musculinus
Alopecia, pruritus, dermatitis
Pluck fur, scrape skin
Ivermectin/Mitaban

A

Mites

84
Q

2 Misc health conditions:

A

moist dermatitis

Neoplasia

85
Q

Moist dermatitis=

Neoplasia=

A

wet housing condition

mammary tumors

86
Q

Nutrition of rodents:

A

Omnivores
pelleted diets are preferable to see mixtures
Food should be in crocks or hoppers
Fresh water

87
Q

3 ways to euthanize rodents:

A
  1. Overdose of isoflurance, halothane or sevoflurance (last resort)(inhalants)
  2. Overdose of injectable barbiturate(euthanasia solution)(clinical setting)(IP)
  3. Overdose of CO2 (research setting)
88
Q

Overdose of CO2 will not be successful in mice under ____ weeks of age; resistant to hypoxia

A

16

89
Q

Never _________ CO2 chamber for euthanasia

A

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Tech 4 (8 decks)

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