Mice

Question 1

What is the scientific name for mice?

Answer 1

Mus musculus

Question 2

What are the 3 main categories of mice?

Answer 2

Outbred stocks, inbred strains and F1 hybrids

Question 3

What are the 4 ecologic type of mice?

Answer 3

Axenic (free of microbes not needed to sustain life), Gnotobiotic (known microflora), Specific pathogen free, conventional (animals with undefined microflora)

Question 4

How many generations does it take to make inbred strains?

Answer 4

20 or more

Question 5

How much homozygosity do inbred strains have?

Answer 5

greater than 97%

Question 6

What do athymic nude mice lack?

Answer 6

T cells

Question 7

SCID mice lack what?

Answer 7

Both T and B cells

Question 8

What are F1 hybrids?

Answer 8

The first progeny between 2 different inbred strains

Question 9

How are transgenic mice made?

Answer 9

When foreign DNA is introduced into the cells during early embryonic development

Question 10

How are knockout mice made?

Answer 10

Introducing a transgene, knocks out specific genes to study loss of function

Question 11

What is it called when a mouse takes the whiskers off another mouse?

Answer 11

Barbering

Question 12

Which teeth are hypsodont and which are brachydont?

Answer 12

Incisors are hypsodont, molars are brachydont

Question 13

What kind of fat do mice use to keep warm?

Answer 13

Brown fat

Question 14

What is the lifespan of a mouse?

Answer 14

1.5-3 years

Question 15

What is the mouse gestation period?

Answer 15

19-21 days

Question 16

What is the weaning period?

Answer 16

21-28 days

Question 17

What is the mouse litter size?

Answer 17

10-12

Question 18

What is the Whitten effect?

Answer 18

Females introduced to males will cycle within 3 days

Question 19

What is the Bruce effect?

Answer 19

If a pregnant female smells a strange male within 4 days of conception, she will abort the current pregnancy

Question 20

How much food do mice consume?

Answer 20

3-5 g per day

Question 21

What must you do to a mouse before getting blood?

Answer 21

Anesthetize it

Question 22

Which veins are good for a small amount of blood in rats?

Answer 22

Dorsal tail artery or clipped toenail

Question 23

Which vein is good for a larger volume of blood?

Answer 23

Jugular vein

Question 24

What is the max amount of blood that can be taken in mice? How much blood do mice have in their bodies?

Answer 24

0.2 ml is the max.

Mice have 1.6-3.2 ml of blood

Question 25

What is the max amount that can be injected into a mouse?

Answer 25

1-2 ml

Question 26

What are the needle sizes used to give injections?

Answer 26

23 and 25 gauge

Question 27

What pain medications is recommended postop for rodents?

Answer 27

Butorphenol

Question 28

How much saline can be given to mice during anesthesia?

Answer 28

1-2 ml per 100 g body weight

Question 29

What is the preferred method of euthanasia for rodents?

Answer 29

CO2 chamber

Question 30

What is a good antibiotic to treat pneumonia?

Answer 30

Enrofloxacin (Baytril)

Question 31

What does Helicobacter cause in the body? What is it associated with?

Answer 31

Active chronic hepatitis | Associated with IBD.

Question 32

What is the most common respiratory disease in mice?

Answer 32

Mycoplasma pulmonis

Question 33

Tyzzer's disease is caused by what?

Answer 33

Clostridium pilaforme

Question 34

What does Citrobacter freundii cause? How is it transmitted?

Answer 34

Transmissible murine colonic hyperplasia | Transmitted via fecal/oral route

Question 35

What are clinical signs of Transmissible murine colonic hyperplasia?

Answer 35

Depression, anorexia, hunched posture, dehydration, rough hair coat, rectal prolapse

Question 36

What are clinical signs of Staph?

Answer 36

Dermatitis, foot swelling, SQ lumps, skin lesions, pneumonia, toxemia, septicemia

Question 37

How can pseudomonas aeruginosa be avoided?

Answer 37

By chlorinating drinking water to a pH of 2.5-2.8

Question 38

Strep is associated with what?

Answer 38

Dermatitis

Question 39

Corynebacterium pseudodiptheriticum is associated with what?

Answer 39

Severe hyperkeratotic dermatitis in nude mice, flaky skin and pruritis

Question 40

Which zoonotic bacteria can come from mice?

Answer 40

Salmonella

Question 41

What is the most common viral infection in mice?

Answer 41

Sendai virus

Question 42

How do you burn out Mouse Hepatitis Virus?

Answer 42

Cease breeding for 3-6 weeks

Question 43

What is a zoonotic virus that can come from mice and is of public health importance?

Answer 43

Lymphocytic Choriomeningitis (LCM)

Question 44

What is a rare pox virus that can come from mice?

Answer 44

Ectromelia

Question 45

What is Myobia musculi and what is Polyplax serrata?

Answer 45

A mite and a louse

Question 46

What is the best bedding for mice and rats?

Answer 46

Paper

Question 47

What are knockout mice used for?

Answer 47

Immunological research

Question 48

How are oral medications given?

Answer 48

Gavage

Question 49

What type of reproductive cycle do mice have?

Answer 49

Polyestrus, but are NOT induced ovulators

Question 50

What are transgenic mice used for?

Answer 50

Genetic biomedical research

Question 51

What is the house mouse louse?

Answer 51

Polyplax serrata