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Exotics > Mice > Flashcards

Mice Flashcards

1
Q

What is the scientific name for mice?

A

Mus musculus

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2
Q

What are the 3 main categories of mice?

A

Outbred stocks, inbred strains and F1 hybrids

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3
Q

What are the 4 ecologic type of mice?

A

Axenic (free of microbes not needed to sustain life), Gnotobiotic (known microflora), Specific pathogen free, conventional (animals with undefined microflora)

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4
Q

How many generations does it take to make inbred strains?

A

20 or more

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5
Q

How much homozygosity do inbred strains have?

A

greater than 97%

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6
Q

What do athymic nude mice lack?

A

T cells

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7
Q

SCID mice lack what?

A

Both T and B cells

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8
Q

What are F1 hybrids?

A

The first progeny between 2 different inbred strains

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9
Q

How are transgenic mice made?

A

When foreign DNA is introduced into the cells during early embryonic development

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10
Q

How are knockout mice made?

A

Introducing a transgene, knocks out specific genes to study loss of function

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11
Q

What is it called when a mouse takes the whiskers off another mouse?

A

Barbering

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12
Q

Which teeth are hypsodont and which are brachydont?

A

Incisors are hypsodont, molars are brachydont

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13
Q

What kind of fat do mice use to keep warm?

A

Brown fat

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14
Q

What is the lifespan of a mouse?

A

1.5-3 years

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15
Q

What is the mouse gestation period?

A

19-21 days

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16
Q

What is the weaning period?

A

21-28 days

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17
Q

What is the mouse litter size?

A

10-12

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18
Q

What is the Whitten effect?

A

Females introduced to males will cycle within 3 days

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19
Q

What is the Bruce effect?

A

If a pregnant female smells a strange male within 4 days of conception, she will abort the current pregnancy

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20
Q

How much food do mice consume?

A

3-5 g per day

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21
Q

What must you do to a mouse before getting blood?

A

Anesthetize it

22
Q

Which veins are good for a small amount of blood in rats?

A

Dorsal tail artery or clipped toenail

23
Q

Which vein is good for a larger volume of blood?

A

Jugular vein

24
Q

What is the max amount of blood that can be taken in mice? How much blood do mice have in their bodies?

A

0.2 ml is the max.

Mice have 1.6-3.2 ml of blood

25
Q

What is the max amount that can be injected into a mouse?

A

1-2 ml

26
Q

What are the needle sizes used to give injections?

A

23 and 25 gauge

27
Q

What pain medications is recommended postop for rodents?

A

Butorphenol

28
Q

How much saline can be given to mice during anesthesia?

A

1-2 ml per 100 g body weight

29
Q

What is the preferred method of euthanasia for rodents?

A

CO2 chamber

30
Q

What is a good antibiotic to treat pneumonia?

A

Enrofloxacin (Baytril)

31
Q

What does Helicobacter cause in the body? What is it associated with?

A

Active chronic hepatitis

Associated with IBD.

32
Q

What is the most common respiratory disease in mice?

A

Mycoplasma pulmonis

33
Q

Tyzzer’s disease is caused by what?

A

Clostridium pilaforme

34
Q

What does Citrobacter freundii cause? How is it transmitted?

A

Transmissible murine colonic hyperplasia

Transmitted via fecal/oral route

35
Q

What are clinical signs of Transmissible murine colonic hyperplasia?

A

Depression, anorexia, hunched posture, dehydration, rough hair coat, rectal prolapse

36
Q

What are clinical signs of Staph?

A

Dermatitis, foot swelling, SQ lumps, skin lesions, pneumonia, toxemia, septicemia

37
Q

How can pseudomonas aeruginosa be avoided?

A

By chlorinating drinking water to a pH of 2.5-2.8

38
Q

Strep is associated with what?

A

Dermatitis

39
Q

Corynebacterium pseudodiptheriticum is associated with what?

A

Severe hyperkeratotic dermatitis in nude mice, flaky skin and pruritis

40
Q

Which zoonotic bacteria can come from mice?

A

Salmonella

41
Q

What is the most common viral infection in mice?

A

Sendai virus

42
Q

How do you burn out Mouse Hepatitis Virus?

A

Cease breeding for 3-6 weeks

43
Q

What is a zoonotic virus that can come from mice and is of public health importance?

A

Lymphocytic Choriomeningitis (LCM)

44
Q

What is a rare pox virus that can come from mice?

A

Ectromelia

45
Q

What is Myobia musculi and what is Polyplax serrata?

A

A mite and a louse

46
Q

What is the best bedding for mice and rats?

A

Paper

47
Q

What are knockout mice used for?

A

Immunological research

48
Q

How are oral medications given?

A

Gavage

49
Q

What type of reproductive cycle do mice have?

A

Polyestrus, but are NOT induced ovulators

50
Q

What are transgenic mice used for?

A

Genetic biomedical research

51
Q

What is the house mouse louse?

A

Polyplax serrata

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