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Immunology > MHC > Flashcards

MHC Flashcards

1
Q

What is component of MHC 1?

A

All nucleated cells

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2
Q

What is component of MHC 2?

A

APC - dendritic cell, b cell + macrophages

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3
Q

What is CD4+?

A

HELPER CELLS -> MHC 2

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4
Q

What is CD8+?

A

CYTOTOXIC -> MHC 1

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5
Q

how much alpha + beta in MHC 1?

A

3 alpha + 1 beta

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6
Q

how much alpha + beta in MHC 2?

A

2 alpha + 2 beta

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7
Q

how much Cytoplasmic tail in transmembrane region in MHC 1?

A

1

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8
Q

how much Cytoplasmic tail in transmembrane region in MHC 2?

A

2

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9
Q

Where is the peptide binding cleft/variable region in MHC 1?

A

between alpha 1 + 2

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10
Q

Where is the peptide binding cleft/ variable region in MHC 2?

A

between alpha + beta

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11
Q

What is cytoplasmic tail in transmembrane region?

A

for signal transduction

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12
Q

is alpha or beta needed for signal transduction in MHC 1?

A

alpha

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13
Q

Does MHC 1 go through membrane?

A

yes its transmembrane.

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14
Q

Which alpha in MHC 1 bind to CD8?

A

alpha 3

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15
Q

At the peptide binding cleft of MHC 1 - how many amino acids does it bind to?

A

8-10 amino acids

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16
Q

What beta is in MHC 1?

A

BETA 2 MICROGLOBULIN

17
Q

Is beta necessary for MHC 1?

A

Without it we can’t make MHC 1

18
Q

How does MHC 1 get expressed?

A

Virus enter –> phagosome –> ubiquinated –> peptide –> enter via TAP to ER –> MHC 1 go through er to golgi to vesicle –> MHC 1 go out.

19
Q

What is HLA?

A

same as MHC

20
Q

Where is binding cleft in MHC2?

A

alpha 1 + beta 1

21
Q

Where is the conservative in MHC2?

A

alpha 2 + beta 2

22
Q

At the peptide binding cleft of MHC 2 - how many amino acids does it bind to?

A

13-25 amino acids

23
Q

Which beta in MHC 2 bind to CD4?

A

beta 2

24
Q

How many locis encode for MHC 2?

A

5

25
Q

How does MHC 2 get expressed?

A

antigen –> endolysosome –> ER –> MHC 2 + invarient chain –> golgi –> vesicle –> CLIP –> break invarient –> HLA –> break clip –> MHC 2

26
Q

How many peptides bind at once in MHC?

A

1

27
Q

What does MHC require of cells?

A

T

28
Q

What increases level of MHC?

A

CYTOKINES

29
Q

Peptides from ___ associate with MHC I

A

cytosol

30
Q

Peptides from ___ associate with MHC 2

A

vesicles

31
Q

HLAs in MHC 1:

A

HLA- a/b/c

32
Q

HLAs in MHC 2:

A

HLA- D p/q/r

33
Q

which MHC has endogenous antigens and which has exogenous antigens?

A

MHC 1: endogenous

2: exogenous

Immunology (8 decks)

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