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Immunology > B cell activation #1 > Flashcards

B cell activation #1 Flashcards

1
Q

What is the T cell function where: 1 inhibits the other?

A

ANTAGONISTS

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2
Q

What is the T cell function where: 1 does many functions?

A

PLEITROPHY

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3
Q

What is the T cell function where: 1 does only 1 job?

A

REDUNDANCY

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4
Q

What is the T cell function where: 1 works with 2 things?

A

SYNERGY

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5
Q

What does a C-C chemokine mean?

A

double cystine no AA

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6
Q

What does a CXC chemokine mean?

A

A.A between cystine

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7
Q

What is CXCL8 and what does it bind to?

A

It is IL8

binds to CXCR2

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8
Q

What lymphocyte is in humoral immunity?

A

B

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9
Q

What does the humoral immunity bind to?

A

proteins, polysaccharide, phospholipid + nucleic acid antigen

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10
Q

What does the humoral immunity act on?

A

soluble + free antigens

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11
Q

Does humoral immunity provide immunity to extra/intracellular bacteria, virus + toxin?

A

extracellular

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12
Q

What type of hypersensitivity is humoral immunity ?

A

1,2 and 3

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13
Q

Which between active/ passive adapted immunity:
produced after exposure/ immediately…
Last for long/short period…
Where are Ab obtained…

A

ACTIVE: after exposure + long + produce Ab
PASSIVE: immediately+ short + Ab obtained from outside

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14
Q

Which response- primary or secondary- produces more Ab?

A

secondary

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15
Q

Which response- primary or secondary-is slower?

A

primary

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16
Q

Which Ig is in Naiive B cells?

A

IgM+IgD

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17
Q

Do plasma cells proliferate?

A

no

18
Q

Are plasma cells T dependent or not?

A

t dependent

19
Q

Where do plasma cells migrate to?

A

lymph nodes

20
Q

Where does the short-lived plasma cells develop?

A

germinal center

21
Q

Are memory cells dormant? and where do they develop?

A

yes-germinal centers of secondary lymphoid organs

22
Q

Explain B cell maturation + locations?

A

BM: stem cell -> pro B -> pre B -> immature B
lymphoid: mature B -> memory B -> plasma B

23
Q

Where is heavy chain rearrangement done at B cell maturation?

A

pro B -> pre B

24
Q

Where is light chain rearrangement done at B cell maturation?

A

Immature B

25
Q

Which Ig does immature B have?

A

IgM

26
Q

Which Ig does mature B have?

A

IgM + IgD

27
Q

Which Ig does plasma cell have?

A

IgG/ IgA/ IgE/ IgM

28
Q

Which cell t independent 1 or t independent 2 is mitogenic?

A

T independent cell 1 (TI1)

29
Q

Which cell t independent 1 function?

A

Proliferate B cell + polyclonal (bind to > epitopes of antigens)

30
Q

Which cell t independent 2function?

A

make antibody response

31
Q

What is the best example of T independent 1?

A

LPS for E.coli & protein coat of polio virus

32
Q

What is the best example of T independent 2?

A

Bacterial and fungal polysaccharides

33
Q

What Ig does t dependent vs t independent have?

A

t independent: IgM

T dependent: IgM + IgG

34
Q

Where is TI1 found, its feature and which B cell is here?

A

marginal zone of spleen (secondary lymphoid organ)
rapid
B-1

35
Q

How do light chains form?

A

VJ recombination: VJ recombinase

Transcription DNA -> primary RNA -> Splicing

VJC: We get VJ –C segment (CAN BE V2 OR V35 etc! ITS ALL FOR VARIATION)

Translated: makes kappa chain (variable + constant)

36
Q

How does heavy chains form?

A

VDJ: We get VD –J segment

VDJ + mui

ALTERNATIVE SPLICING: VDJ binds with mui + VDJ binds with delta (since B has IgD + IgM)

Translated: proteins -> make mui + delta heavy chain

37
Q

What does V,D,J,L,C mean?

A 
L: leader
V: variable 
J: joining 
C: constant 
D: diversity
38
Q

how many locis are heavy + light chain?

A

Light chain: 1 loci

Heavy chain: 2 loci

39
Q

Does diversity chains have domain?

A

yes! There are 4.

40
Q

Where is B1 cells found?

A

peritoneal + pleural cavities

41
Q

What Ig does B1 produce? Discuss affinity and reactivity.

A

IgM –> low affinity + polyreactive

42
Q

What is B1 defense against?

A

bacteria who have polysaccharides

Immunology (8 decks)

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