B cell activation #1

Question 1

What is the T cell function where: 1 inhibits the other?

Answer 1

ANTAGONISTS

Question 2

What is the T cell function where: 1 does many functions?

Answer 2

PLEITROPHY

Question 3

What is the T cell function where: 1 does only 1 job?

Answer 3

REDUNDANCY

Question 4

What is the T cell function where: 1 works with 2 things?

Answer 4

SYNERGY

Question 5

What does a C-C chemokine mean?

Answer 5

double cystine no AA

Question 6

What does a CXC chemokine mean?

Answer 6

A.A between cystine

Question 7

What is CXCL8 and what does it bind to?

Answer 7

It is IL8

binds to CXCR2

Question 8

What lymphocyte is in humoral immunity?

Answer 8

B

Question 9

What does the humoral immunity bind to?

Answer 9

proteins, polysaccharide, phospholipid + nucleic acid antigen

Question 10

What does the humoral immunity act on?

Answer 10

soluble + free antigens

Question 11

Does humoral immunity provide immunity to extra/intracellular bacteria, virus + toxin?

Answer 11

extracellular

Question 12

What type of hypersensitivity is humoral immunity ?

Answer 12

1,2 and 3

Question 13

Which between active/ passive adapted immunity:
produced after exposure/ immediately…
Last for long/short period…
Where are Ab obtained…

Answer 13

ACTIVE: after exposure + long + produce Ab
PASSIVE: immediately+ short + Ab obtained from outside

Question 14

Which response- primary or secondary- produces more Ab?

Answer 14

secondary

Question 15

Which response- primary or secondary-is slower?

Answer 15

primary

Question 16

Which Ig is in Naiive B cells?

Answer 16

IgM+IgD

Question 17

Do plasma cells proliferate?

Answer 17

no

Question 18

Are plasma cells T dependent or not?

Answer 18

t dependent

Question 19

Where do plasma cells migrate to?

Answer 19

lymph nodes

Question 20

Where does the short-lived plasma cells develop?

Answer 20

germinal center

Question 21

Are memory cells dormant? and where do they develop?

Answer 21

yes-germinal centers of secondary lymphoid organs

Question 22

Explain B cell maturation + locations?

Answer 22

BM: stem cell -> pro B -> pre B -> immature B
lymphoid: mature B -> memory B -> plasma B

Question 23

Where is heavy chain rearrangement done at B cell maturation?

Answer 23

pro B -> pre B

Question 24

Where is light chain rearrangement done at B cell maturation?

Answer 24

Immature B

Question 25

Which Ig does immature B have?

Answer 25

IgM

Question 26

Which Ig does mature B have?

Answer 26

IgM + IgD

Question 27

Which Ig does plasma cell have?

Answer 27

IgG/ IgA/ IgE/ IgM

Question 28

Which cell t independent 1 or t independent 2 is mitogenic?

Answer 28

T independent cell 1 (TI1)

Question 29

Which cell t independent 1 function?

Answer 29

Proliferate B cell + polyclonal (bind to > epitopes of antigens)

Question 30

Which cell t independent 2function?

Answer 30

make antibody response

Question 31

What is the best example of T independent 1?

Answer 31

LPS for E.coli & protein coat of polio virus

Question 32

What is the best example of T independent 2?

Answer 32

Bacterial and fungal polysaccharides

Question 33

What Ig does t dependent vs t independent have?

Answer 33

t independent: IgM | T dependent: IgM + IgG

Question 34

Where is TI1 found, its feature and which B cell is here?

Answer 34

marginal zone of spleen (secondary lymphoid organ) rapid B-1

Question 35

How do light chains form?

Answer 35

VJ recombination: VJ recombinase Transcription DNA -> primary RNA -> Splicing VJC: We get VJ –C segment (CAN BE V2 OR V35 etc! ITS ALL FOR VARIATION) Translated: makes kappa chain (variable + constant)

Question 36

How does heavy chains form?

Answer 36

VDJ: We get VD –J segment VDJ + mui ALTERNATIVE SPLICING: VDJ binds with mui + VDJ binds with delta (since B has IgD + IgM) Translated: proteins -> make mui + delta heavy chain

Question 37

What does V,D,J,L,C mean?

Answer 37

``` L: leader V: variable J: joining C: constant D: diversity ```

Question 38

how many locis are heavy + light chain?

Answer 38

Light chain: 1 loci | Heavy chain: 2 loci

Question 39

Does diversity chains have domain?

Answer 39

yes! There are 4.

Question 40

Where is B1 cells found?

Answer 40

peritoneal + pleural cavities

Question 41

What Ig does B1 produce? Discuss affinity and reactivity.

Answer 41

IgM --> low affinity + polyreactive

Question 42

What is B1 defense against?

Answer 42

bacteria who have polysaccharides