B cell activation #1 Flashcards
What is the T cell function where: 1 inhibits the other?
ANTAGONISTS
What is the T cell function where: 1 does many functions?
PLEITROPHY
What is the T cell function where: 1 does only 1 job?
REDUNDANCY
What is the T cell function where: 1 works with 2 things?
SYNERGY
What does a C-C chemokine mean?
double cystine no AA
What does a CXC chemokine mean?
A.A between cystine
What is CXCL8 and what does it bind to?
It is IL8
binds to CXCR2
What lymphocyte is in humoral immunity?
B
What does the humoral immunity bind to?
proteins, polysaccharide, phospholipid + nucleic acid antigen
What does the humoral immunity act on?
soluble + free antigens
Does humoral immunity provide immunity to extra/intracellular bacteria, virus + toxin?
extracellular
What type of hypersensitivity is humoral immunity ?
1,2 and 3
Which between active/ passive adapted immunity:
produced after exposure/ immediately…
Last for long/short period…
Where are Ab obtained…
ACTIVE: after exposure + long + produce Ab
PASSIVE: immediately+ short + Ab obtained from outside
Which response- primary or secondary- produces more Ab?
secondary
Which response- primary or secondary-is slower?
primary
Which Ig is in Naiive B cells?
IgM+IgD
Do plasma cells proliferate?
no
Are plasma cells T dependent or not?
t dependent
Where do plasma cells migrate to?
lymph nodes
Where does the short-lived plasma cells develop?
germinal center
Are memory cells dormant? and where do they develop?
yes-germinal centers of secondary lymphoid organs
Explain B cell maturation + locations?
BM: stem cell -> pro B -> pre B -> immature B
lymphoid: mature B -> memory B -> plasma B
Where is heavy chain rearrangement done at B cell maturation?
pro B -> pre B
Where is light chain rearrangement done at B cell maturation?
Immature B
Which Ig does immature B have?
IgM
Which Ig does mature B have?
IgM + IgD
Which Ig does plasma cell have?
IgG/ IgA/ IgE/ IgM
Which cell t independent 1 or t independent 2 is mitogenic?
T independent cell 1 (TI1)
Which cell t independent 1 function?
Proliferate B cell + polyclonal (bind to > epitopes of antigens)
Which cell t independent 2function?
make antibody response
What is the best example of T independent 1?
LPS for E.coli & protein coat of polio virus
What is the best example of T independent 2?
Bacterial and fungal polysaccharides
What Ig does t dependent vs t independent have?
t independent: IgM
T dependent: IgM + IgG
Where is TI1 found, its feature and which B cell is here?
marginal zone of spleen (secondary lymphoid organ)
rapid
B-1
How do light chains form?
VJ recombination: VJ recombinase
Transcription DNA -> primary RNA -> Splicing
VJC: We get VJ –C segment (CAN BE V2 OR V35 etc! ITS ALL FOR VARIATION)
Translated: makes kappa chain (variable + constant)
How does heavy chains form?
VDJ: We get VD –J segment
VDJ + mui
ALTERNATIVE SPLICING: VDJ binds with mui + VDJ binds with delta (since B has IgD + IgM)
Translated: proteins -> make mui + delta heavy chain
What does V,D,J,L,C mean?
L: leader V: variable J: joining C: constant D: diversity
how many locis are heavy + light chain?
Light chain: 1 loci
Heavy chain: 2 loci
Does diversity chains have domain?
yes! There are 4.
Where is B1 cells found?
peritoneal + pleural cavities
What Ig does B1 produce? Discuss affinity and reactivity.
IgM –> low affinity + polyreactive
What is B1 defense against?
bacteria who have polysaccharides
