MHC Flashcards
What cells recognise antigens?
T cells
B cells
what is a B cell receptor?
surface immunoglobulin
what is a T cell receptor?
T cell receptor
what does MHC bind?
peptide fragments derived from pathogens
where does MHC display peptide fragments from pathogens?
cell surface for recognition by appropriate T cells
where are MHC proteins encoded?
in large cluster of genes on chromosome 6
what are the 2 MHC families?
class I
class II
Where is MHC class I expressed?
nucleated cells
where is MHC class II expressed?
leukocytes
what differentiates MHC class I and II?
similar 3D structure different SUBUNIT
protein binding cleft is more open in MHC Class I
What MHC does an individual express?
2 forms
What is the main function of MHC?
T cells can only see antigens associated with MHC
What are the functions of MHC class I and II?
I - presents peptides to cytotoxic cells
II - presents peptides to helper T cells
In what clinical case does MHC have to match?
tissue grafting
what patients are found with HLA-B27?
Ankylosing spondylitis
