Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Immunoglobulins > Flashcards

Immunoglobulins Flashcards

1
Q

What are immunoglobulins?

A

Antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where would you find immunoglobulins?

A

Plasma, tissues, secretions and lymphatics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What immune system produces immunoglobulins?

A

Humoral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What cells secrete immunoglobulins?

A

activated B cells - plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 5 classes of immunoglobulins?

A

IgG, IgM, IgA, IgD, IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What 2 regions do you find on the light and heavy chains?

A

variable and constant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What part recognises foreign material?

A

Fragment antigen binding (FAB) arms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What type of molecules interact with Fc?

A

effector molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What do light chains fold up in to?

A

VL (variable light)
CL (constant light)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What chain determines the class of the antibody?

A

heavy chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How many globular domains does the heavy chain fold into?

A

4 or 5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the heavy chain globular domains?

A

VH
CH1
CH2
CH3
CH4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What causes each antibody to have its own unique binding site?

A

Hypervariable loops (CDR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How many CDR’s create the antigen binding site?

A

6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the structural part of the antigen that is recognised?

A

epitope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Where is the antigen binding site?

A

tip of the FAB arms

17
Q

What is the antigen binding site formed by?

A

Vh and Vl domains

18
Q

What is the name of the manmade carbon molecule?

A

Buckminsterfullerene C60

19
Q

What is C60 used for?

A

immunise mice and generate antibodies

20
Q

What is the most abundant immunoglobin in plasma?

A

IgG

21
Q

What is the only immunoglobulin to cross placenta from mother to foetus?

A

IgG

22
Q

What is the predominant antibody of the secondary response?

A

IgG

23
Q

Where is IgM found?

A

plasma and secretions

24
Q

In IgM, what joins the units?

A

J chain and disulphide bonds

25
Q

How many units are in IgM so how many binding sites are there?

A

5
10

26
Q

What is the predominant antibody of the primary response?

A

IgM

27
Q

What is the major antibody of seromucous secretions?

A

IgA

28
Q

What are the 2 forms of IgA?

A

Monomeric (serum) and dimeric (secretory)

29
Q

What are dimers of IgA held together by?

A

J bonds and SC

30
Q

What immunoglobulin is associated with the allergic response and parasitic infections?

A

IgE

31
Q

Where is IgE expressed?

A

mast cells and basophils

32
Q

Where is IgD found?

A

Surface of lymphocytes

33
Q

What are Fc receptors?

A

Effector molecules that bind to Fc region on immunoglobulins

Immunology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions