Autoimmunity Flashcards
What is a result of the immune system breaking down self-tolerant mechanisms?
autoimmunity
what is a symptom of Hashimoto’s thyroiditis?
enlarged thyroid
what are the 2 types of autoimmune disease?
organ-specific
non organ-specific
where would you find organ-specific autoimmune disease?
thyroid
stomach
adrenal
pancreas
where would you find non organ-specific autoimmune disease?
muscle
kidney
skin
joints
what MHC is associated with autoimmune disease?
HLA
what type of antibodies are directly pathogenic?
autoantibodies
what autoimmune disease is caused by autoantibodies?
thyrotoxicosis
what type of hypersensitivity do autoantibodies LOCALISED to an organ trigger?
type II
what type of hypersensitivity do autoAg in systetm trigger?
type III
What are some autoimmune diseases affecting head and neck?
Hashimoto’s thyroiditis
Graves disease
Sjorgrens syndrome
what is Sjorgrens syndrome characterised by?
lymphocytic infiltrate in salivary and lacrimal glands
what does Sjorgrens syndrome result in?
lack of saliva and tear secretion = caries , candida
what are some treatments of autoimmune disorders?
anti-thyroid drugs
anti-inflammatory drugs
immunosuppressive drugs
monoclonal antibodies
how would you treat rheumatoid arthritis?
TNF antibody
