Metabolism Pathogens 1 Flashcards
Streptococcus pyogens is gram stain?
Gram (+) ; cocci
Streptococcus pyogenes causes ?
Strep throat, scarlet fever, Rheumatic fever, necrotizing fasciitis
Streptococcus pyogenes pathogenesis
Displays M protein
- aids in colonization
- antiphagocytic ( protein will not allow to be phagocotized )
Hyaluronic acid capsule (glue connective tissue )
- helps evade immune system
- resist phagocytosis
Produces exoenxymes:
- streptokinase : break down clots attempting to isolate streptococcus pyogenes
- hyaluronidase: hydrolyzes hylauronic acid
Strep throat transmission
Droplet
Strep throat signs/symptoms
Fever, sore throat, tonislitis, enlarged lymph nodes
Scarlet fever transmission
Droplet
Progress from strep throat (untreated)
What does streptococcus pyogenes produce in scarlet fever ?
Erythogenic toxin -> pink/red skin rash
Scarlet fever signs
Skin rash
Spotted, strawberry-like tongue
Rheumatic fever transmission
Autoimmune complication
-mis directed immune reaction againt M protein
Rheumatic fever signs/symptoms
Arthritis
-nodules at joints
Fever
Inflammation of heart
Necrotizing fasciitis is
Flesh eating bacteria
Necrotizing fasciitis transmission ?
Streptococcus pyogens enters through breaks in skin
Streptococcus pyogens produce ?
Toxins that destory tissue
Spread quickly
Streptococcus pyogenes dx
Culture
Detection of streptococcus pyogenes antigen test
Streptococcus pyogenes tx
Penicillins or cephalosporins
In metabolic pathways consist if multiple steps and the product of one rxn =
Reactant of the next rxn
Stops cell from making more product than it needs
Feedback inhibition
Loss of electrons
Oxidation
Gain of eelctrons
Reductions
Reduction and oxidation rxn are coupled
Coupling redox reactions
