Metabolism IV - Week 1 Flashcards
What is meant by lipogenesis?
Fatty acid synthesis
De novo synthesis of fatty acids occurs…
Mainly in the liver, kidney, mammary glands, adipose tissue & brain
When does lipogenesis usually take place?
During excess energy intake
triglycerides formed in the liver are transported to adipose tissue by…
VLDL
What kind of process is lipogenesis?
Reductive
What is the substrate of lipogenesis?
Acetyl-CoA
How is Acetyl-CoA for lipogenesis usually formed?
By the pyruvate dehydrogenase complex
How does Acteyl-CoA enter the mitochondrial matrix?
Converted to Citric Acid due to TCA which can diffuse across
In lipogenesis, Acetyl-CoA must be converted to…
Malonyl-CoA
What is the crucial regulatory enzyme in lipogenesis?
Acetyl-CoA carboxylase
Where is acetyl-CoA carboxylase found?
Liver
What is the direct precursor for lipogenesis?
Malonyl-CoA
What is the purpose of fatty acid synthase?
Catalyses synthesis of saturated long-chain fatty acids from malonyl-CoA, acteyl-CoA and NADPH
Fatty acid synthase uses which compounds as precursors?
Acetyl-CoA and malonyl-CoA
What is the electron donor for fatty acid synthase?
NADPH
