Causes of liver disease - Week 6

Question 1

What is the definition of Chronic liver disease?

Answer 1

Leads to Cirrhosis

Question 2

What is NAFLD?

Answer 2

Fatty Liver or steato-hepatitis in absence of other cause

Question 3

Which factor is at the centre of NAFLD?

Answer 3

Oxidative stress

Question 4

Which metabolic syndromes are associated with NAFLD?

Answer 4

Type 2 Diabetes, Obesity, HDL Cholesterol, Hypertension, Triglycerides raised

Question 5

What is meant by NASH?

Answer 5

Type of NAFLD - If you have NASH, you have inflammation and liver cell damage, along with fat in your liver.
‎Symptoms & Causes · ‎Treatment · ‎Nafld · ‎Cirrhosis

Question 6

What is the difference between simple steatosis and NASH?

Answer 6

Simple steatosis has no influence on lover outcome (CV outcome) but NASH can progress to cirrhosis

Question 7

What is meant by primary biliary cholangitis?

Answer 7

autoimmune disease of the liver. It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver

Question 8

What is the typical presentation of primary biliary cholangitis?

Answer 8

Middle aged woman
Usually asymptomatic/ Incidental
Fatigue 
Itch without rash
Xanthesalma and xanthomas

Question 9

Primary Biliary Cholangitis may result in…

Answer 9

Liver failure/transplantation

Question 10

Which group are more affected by auto-immune hepatitis?

Answer 10

Women

Question 11

What is a complication of auto-immune hepatitis?

Answer 11

Cirrhosis

Question 12

Type 1 Auto-immune Hepatitis is more common in…

Answer 12

Adults

Question 13

Type 2 Auto-immune Hepatitis is more common in…

Answer 13

Children

Question 14

Which conditions are commonly associated with Type 1 Auto-immune hepatitis?

Answer 14

Autoimmune thyroiditis, graves disease, chronic UC

Question 15

Give some symptoms of auto-immune Hepatitis.

Answer 15

malaise, fatigue, lethargy, nausea, abdominal pain, anorexia

Question 16

What may be found O/E of a patient with auto-immune Hepatitis?

Answer 16

Hepatomegaly
Jaundice
Stigmata of chronic liver disease
Splenomegaly

Question 17

What is the treatment for Auto-immune hepatitis?

Answer 17

Corticosteroids

Azathioprine

Question 18

What is meant by primary sclerosing cholangitis?

Answer 18

Autoimmune destructive disease of large and medium sized bile ducts

Question 19

Primary Sclerosing Cholangitis is associated with…

Answer 19

Ulcerative Colitis

Question 20

What is the treatment for Primary Sclerosing Cholangitis?

Answer 20

Treatment maintain bile flow, monitor for cholangiocarcinoma and colo-rectal cancer

Question 21

What is Haemochromatosis?

Answer 21

Genetic Iron overload syndrome

Question 22

Which syndromes are associated with Haemochromatosis?

Answer 22

Cirrhosis, cardiomyopathy, Pancreatic failure (Diabetes)

Question 23

How is haemochromatosis treated?

Answer 23

Venesection

Question 24

What is meant by Wilson’s Disease?

Answer 24

loss of function or loss of protein mutations in caeruloplasmin (Copper binding protein)

Question 25

Alpha 1 anti-trypsin deficiency causes…

Answer 25

Lung emphysema & Liver deposition of mutant protein, cell damage

Question 26

What is meant by Budd-Chiari?

Answer 26

Thrombosis of the hepatic veins

Thrombotic tendency, protein C or S deficiency

Question 27

Why is Methotrexate important in liver disease?

Answer 27

Drug used to treat Rheumatoid arthritis and psoriasis which may cause progressive fibrosis - monitoring necessary

Question 28

What is meant by Cardiac Cirrhosis?

Answer 28

Cirrhosis secondary to increased right atrial pressure

Question 29

Give some causes of Cardiac Cirrhosis.

Answer 29

Incompetent tricuspid valve
Congenital
Rheumatic fever
Constrictive pericarditis

Question 30

What is the treatment for Cardiac Cirrhosis?

Answer 30

Treat the cardiac condition