metabolism and energy balance Flashcards

1
Q

how must glucose be processed before it can be used for energy

A

glucose transformed into pyruvate by glycolysis then into a one way conversion to acetyl CoA and then into the citric acid cycle

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2
Q

how must fats be processed to be used as energy

A

beta oxidation turns it into acetyl CoA and then into the citric acid cycle

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3
Q

how is glycogen stored in the body

A

skeletal muscle and liver

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4
Q

how are TAG (triacylglycerides) stored in the body

A

as adipose tissue

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5
Q

what is the process where TAG are converted into acetyl CoA

A

lipolysis

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6
Q

what is the process where non carbohydrate precursor is transformed into glucose

A

gluconeogenesis

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7
Q

what is the process where glycogen is transformed into pyruvate

A

glycogenolysis

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8
Q

all processes in the metabolism chart are reversible except which one.

A

pyruvate –> acetyl CoA

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9
Q

what fuels can the brain utilise

A

glucose primarily and ketone bodies

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10
Q

what are ketone bodies

A

products from acetyl CoA that can sustain the brain when glucose is not available. they are not as effective as glucose

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11
Q

what is the primary energy output of the human body

A

heat and work

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12
Q

what are the two theories for food intake regulation

A

glycostatic theory and lipostatic theory

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13
Q

what is glycostatic theory

A

glucose metabolism by hypothalamic centres regulates food intake

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14
Q

lipostatic theory

A

signals from fat stores send signals which change eating behaviour to maintain a weight

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15
Q

what are nutrient pools

A

nutrients available for immediate use in the plasma

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16
Q

what happens to excess glucose

A

store as muscle or liver glycogen or converted to fat

17
Q

how much ATP can be produced from glucose or glycogen

A

2 from glucose
3 from glycogen

18
Q

how much ATP is produced from a fatty acid

A

6-7 times the ATP of glycogen or glucose

19
Q

what is the citric acid cycle

A

takes acetyl CoA and generates electron donors for Oxidative phosphorylation

20
Q

what is oxidative phosphorylation

A

when oxygen is used to synthesise ATP

21
Q

What is ketoacidosis

A

too many ketone bodies causes an acid pH disturbance

22
Q

when is CO2 produced in energy production

A

with acetyl CoA and in the citric acid cycle

23
Q

what is fed state metabolism

A

it is when nutrients are used for energy, synthesis and storage

24
Q

what is fasted state metabolism

A

glycogen undergoes glycogenolysis back into glucose. Proteins and fats are converted into ATP. Excess acetyl CoA become ketone bodies

25
Q

what cells in the pancreas secrete insulin and glucagon

A

insulin is secreted by beta cells
glucagon is secreted by alpha cells

26
Q

metabolism is primarily controlled by what

A

the ratio of insulin to glucagon

27
Q

how does the body compensate for a drop in plasma glucose.

A

alpha cells release glucagon which stimulates glycogenolysis, gluconeogenesis and ketogenesis

28
Q

what is normal fasting blood glucose level

A

100 mg/dl

29
Q

what is the difference between type 1 and type 2 diabetes

A

type 1 is when there is an insulin deficiency due to beta cell destruction

type 2 is when the body is resistant to the the normal release of insulin

30
Q

how do blood glucose responses change due to exercise training

A

in all individuals, training will increase glucose uptake for an equivalent amount of insulin release

31
Q

how does muscle contractions directly effect glucose uptake

A

contractions cause glucose uptake independant of insulin. It does not matter if the muscle is insulin resistant (type 2)

32
Q

in type 1 diabetics, how do different types of exercise impact glucose trends

A

aerobic lowers
anaerobic elevates