Metabolism 7-11

Question 1

what are the excitatory primary neurones? what is their function?

Answer 1

neuropeptide Y (NPY) and Agouti-related peptide (AgRP)
promotes hunger

Question 2

what is the inhibitory primary neurone? what do they do?

Answer 2

POMC which goes on to release neurotransmitters a-MSH and ß-endorphin
they promote satiety

Question 3

where do the primary neurones project onto? where are they located?

Answer 3

project onto secondary neurones in the satiety centre, located in the arcuate nucleus of the hypothalamus

Question 4

name a hormone that is released from the gut to the hypothalamus which stimulates appetite

Answer 4

ghrelin
peptide hormone released from stomach wall when empty
stimulates excitatory primary neurones (NPY & AgRP) therefore stimulating appetite
full stomach inhibits ghrelin release

Question 5

name a hormone released from the gut to the hypothalamus which suppresses appetite

Answer 5

PYY
released by cells in the ileum & colon (after feeding)
inhibit excitatory primary neurones (suppress appetite)