Metabolic states Flashcards
when does the occur Post absorptive state?
12-18 hours after not eating
what happens during Post absorptive state?
Glucose made in the liver
which organs use the glucose in the Post absorptive state
Brain (co2)
RBC & muscle (lactate, alanine)
what does adipose tissue do during Post absorptive state
TG used to make FA & glycerol for energy or storage
what does the liver take up during Post absorptive state
FA, Glycerol, Alanine, Lactate
how long does the fed state last after eating?
3-6 hours
fatty meal = longer digestion
where is CHO taken up during fed state?
Glucose produce and taken up by liver, muscle, brain, adipose tissue
what happens to CHO during fed state?
used in brain
stored as TG (adipose tissue)
store as glycogen or used making lactate (liver/muscle)
where are AA taken up during fed state?
brain, adipose tissue, liver, muscle
what happens to AA during fed state?
undergoes protein synthesis
what happens to FA during fed state?
packaged into chylomicrons then released into muscle/adipose tissue releasing TG
what happens to chylomicron remnants during fed state?
go to liver and release fat for storage (TG)
liver releases vldl
what happens during exercise (macronutrients) (3)
adipose tissue breaks for TG into FA for energy oxidation
glycogen from liver supplies brain
muscle glycogen stored used
when does a ketogenic state occur?
low insulin, high lipolysis, high acetyl coA
how are ‘ketones’ formed
Acetyl coA x2 = Acetoacetyl coA + coA = Acetoacetate = B-hydroxybutyrate or Acetone
how are the ketones used
acetoacetate = acetoacetyl coA = acetyl CoA (into TCA cycle)
where does the fasting state occur?
18 hours after eating
what happens during fasting state
FA produced in adipose tissue & muscle (oxidised)
Protein broken into AA/Alanine
liver does gluconeogenesis to produce more glucose
ketones or glucose for brain
starvation state defintion
fully adapted to state of food deprivation
what happens during starvation state?
less glucose from liver (less glucose uptake)
more FA release (more ketone use)
