Metabolic and Idiopathic Bone Disease Flashcards
what animals typically get panosteitis?
young, fast-growing large breed dogs
5-12 months old, up to 7 years old
german shepherd dogs
how long may clinical signs of panosteitis last?
up to 9 months
what can be seen on radiographs of panosteitis?
medullary opacity
endosteal thickening
periosteal proliferation
what is hypertrophic pulmonary osteopathy characterized by?
reluctance to move
firm swelling of the distal limbs
lameness
what is vitamin D deficiency caused by a deficiency of?
phosphorous, calcium, or phosphorous
what is vitamin D deficiency?
failure of mineralization of osteoid and cartilaginous matrix
what is the cortex like in rickets?
soft, with curvature and fracture
who does rickets occur in?
puppies
pigs
crias
cattle
what is the histological diagnosis of primary and secondary hyperparathyroidism?
fibrous osteodystrophy
what can secondary hyperparathyroidism be due to?
severe renal disease
nutritional deficiencies
what is osteomalacia?
abnormal softening of bones in adults
what is rickets?
abnormal softening of the bones in children
where does panosteitis have a predisposition to?
proximal to central 1/3 of femur
distal 1/3 of humerus
what is considered to be the source of pain in panosteitis?
medullary edema and capillary distension
who usually gets hypertrophic osteodystrophy?
young, rapidly growing large/giant breeds
2-8 months of age
is hypertrophic osteodystrophy usually bilateral?
yes
what happens in hypertrophic osteodystrophy pathologically?
neutrophil entrapment at chondro-osseous junction in metaphysis
immediately subjacent to physis
inflammation then necrosis
periosteal proliferation due to inflammation
who commonly gets craniomandibular osteopathy?
young scottish westhighland terriers
what is craniomandibular osteopathy like?
severe painful swelling of jaw
pain while eating
abnormal bone formation of flat bones of head
are legg-calve-perthes disease usually bilateral?
no- 12-16%
when is the peak incidence of legg-calve-perthes disease?
5-8 months of age
what is the treatment of choice for legg-calve-perthes disease?
femoral head osteotomy
total hip replacement
what does medical management of legg-calve-perthes disease yield?
25% success rate
what happens in primary and secondary hyperparathyroidism?
resorption of normal bone with replacement by fibrous connective tissue and woven bone
which nutritional deficiencies can lead to secondary hyperparathyroidism?
diet imbalance/deficiency of calcium or phosphorous
vitamin D deficiency
is there treatment for craniomandibular osteopathy?
no
what type of lameness is seen in legg-calve-perthes disease?
chronic non-traumatic hind limb lameness
what is legg-calve-perthes disease likely initiated by?
episodes of ischemia
how long may regression of the bone lesions in hypertrophic pulmonary osteopathy take after the primary mass is removed?
3-4 months
what is seen in rickets?
increased depth of physis and distortion
gross skeletal deformities
cortex soft, curvature and fracture
spinal deformities
joint enlargement
pronounced in costochondral junction
