Menstrual disorders Flashcards

1
Q

What is a menstrual cycle?

A

the time from the first day of a woman’s period to the day before her next period

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2
Q

normal blood loss in a period?

A

80ml over 7 days (16 tsp)

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3
Q

average duration of a period?

A

2-7 days

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4
Q

length of a cycle?

A

28 days ( average 24-35)

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5
Q

disturbances of menstruation - what are the 4 categories?

A

disturbance of menstrual frequency – infrequent or frequent

irregular menstrual bleeding – absent or irregular

abnormal duration of flow – prolonged or shortened

abnormal menstrual volume – heavy or light.

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6
Q

when is a cycle considered frequent/ infrequent

A

< 24 days

> 38 days

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7
Q

when is a cycle considered regular/irregular

A

< 20 days variation in 12 months

>20 days variation in 12 months

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8
Q

what volume of blood loss in one menstrual cycle is considered heavy, normal and light?

A

> 80 ml
5-80ml
<5ml

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9
Q
  • when is it considered heavy?
A
  • Bleeding>8dysmenorrhea0 ml over 7 days, regular cycle

AND/OR the need to change menstrual products every one to two hours

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10
Q

Features of heavy menstrual bleeding?

A

AND/OR passage of clots greater than 2.5 cm
Bleeding through the clothes
AND/OR ‘very heavy’ periods as reported by the woman/affecting quality of life
Can occur alone or in combination with symptoms like dysmenorrhea.
Health Implications e.g. anaemia
20%women in UK have hysterectomy aged <60 due to HMB

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11
Q

Common causes of HMB - UTERINE AND OVARIAN pathologies

A
  • Uterine fibroids (HMB/dysmenorrhoea, pelvic pain)
  • Endometrial polyps (HMB/ intermenstrual bleeding).
  • Endometriosis and adenomyosis (HMB/dysmenorrhoea, dyspareunia, pelvic pain, difficulty conceiving
  • Pelvic inflammatory disease and pelvic infection (for example chlamydia — may also present with vaginal discharge, pelvic pain, intermenstrual and postcoital bleeding, and fever
  • Endometrial hyperplasia or carcinoma (postcoital bleeding, intermenstrual bleeding, pelvic pain).
  • Polycystic ovary syndrome (causes anovulatory menorrhagia and irregular bleeding).
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12
Q

Sytemic diseases and disorders causing HMB? (4)

A
  • Coagulation disorders (for example von Willebrand disease).
  • history of dental bleeding or prolonged injury should be sorted, especially in those with younger age
  • Hypothyroidism (which may also present with fatigue, constipation, intolerance of cold, and hair and skin changes)
  • Liver or renal disease.
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13
Q

Iatrogenic causes of HMB? (3)

A
  • Anticoagulant treatment
  • Herbal supplements (for example ginseng, ginkgo, and soya) — these may cause menstrual irregularities by altering oestrogen levels or coagulation parameters.
  • Intrauterine contraceptive device(CU IUD).
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14
Q

MNEMONIC to remember HMB?

A

P - polyp
A - adenomyosis
L - leiomyoma/fibroid
M - malignancy

C - coagulopathy 
O - ovulation 
E - Endometrium/ hyperplaia
L - latrogenic
N - not yet classified
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15
Q

What are fibroids?

A

Non cancerous growths made of muscle and fibrous tissue. also called myoma or lieomyoma

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16
Q

What can fibroids cause symptom wise? (9)

A

HMB, pelvic pain, urinary symptoms, pressure symptoms, backache , Infertility, miscarriage

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17
Q

diagnosis of fibroids?

A

ultrasound

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18
Q

For HMB +/- small fibroids- what can they be controlled by? (3)

A

COCP
POP
Mirena

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19
Q

options for large fibroids?

A

desired Fibroid embolisation myomectomy

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20
Q

submucosal fibroids - what can be carried out?

A

Hysteroscopic fibroid resection

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21
Q

Declined or failed medical treatment & fertility preservation not required - what is the next step?

A

-Hysterectomy

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22
Q

what is endometriosis?

A

tissue present outside the lining of uterus

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23
Q

what does the tissue do during menstruation if you have endometriosis?

A

ectopic tissue behaves the same as endometrium and bleeds

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24
Q

who does endometriosis effect ?

A

women of reproductive age. 1.5 million women in UK affected.

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25
how may endometriosis present? - what involvement does it have? - what can it cause?
with HMB - pelvic pain - multi system - infertility, fatigue and systemic symptoms
26
symptoms of endometriosis?
Lowe back pain painful cramps that get worse - dysmenorrhoea - abnormal bleeding or spotting doing period - painful urination/ pooing - pain during/ after intercourse
27
endometriosis is often misdiagnosed as it is hard to diagnose with the vague symptoms - what may it be mistaken for?
- IBS - anxiety/depression - stress - fatigue
28
Endometriosis stages - briefly describe them
stage 1 - minimal, may be small patches of surface lesions on or around organs in pelvic cavity stage 2 - mild , begins to infiltrate pelvic organs stage 3 - moderate - peritoneum pelvic side walls and other structures are involved stage 4 - severe - infiltrated and affecting pelvic organs and ovaries - adhesions present
29
diagnosis of endometriosis
- Pelvic examination | - Ultrasound scan, Diagnostic laparoscopy
30
management of endometriosis - medical and surgical
Management Options: Analgesia, Medical, Surgical Medical — COCP, POP, Mirena IUS , Depot provera, GnRH Analogues Surgical- Ablation,Hysterectomy endometrioma excision, pelvic clearance, Hysterectomy Surgical management may be required as part of fe
31
What is Adenomyosis?
condition where endometrium becomes embedded in myometrium .
32
what does Adenomyosis cause?
HMB
33
You may have significant ....? with Adenomyosis
dysmenorrhea.
34
treatment and definitive treatment for adenomyosis?
May respond to hormones partially | - Definitive treatment is hysterectomy
35
Endometrial polyps - overgrowth of endometrial lining can lead to? - polyps are mostly ?
- to formation of pediculated structures called polyps which extend into endometrium - benign
36
mamagement for Endometrial polyps?
polypectomy
37
Management of Heavy menstrual bleeding (lots) - what profile needs to be done
``` - Thorough history Pelvic examination (Speculum,Bimanual) remember to look at cervix - Clotting profile, thyroid function Pelvic Ultrasound scan Laparoscopy if endometriosis suspected ``` ``` Management options depend on: Impact on quality of life Underlying pathology Desire for further fertility Women’s preferences ``` - Endometrial Biopsy from all women aged 44 or above with HMB, refractory to medical treatment
38
with endometrial polyps - what is it always important to look at?
the cervix
39
non hormonal treatment for polyps? (3)
mefenamic acid transexemic acid GnRH analogues
40
what does transexemic acid do?
reduces blood loss 60% | antifibrinolytic)
41
what does mefenamic acid do?
(prostaglandin inhibitor) reduces blood loss 30% and pain
42
when are transexemic acid and mefenamic acid taken? who are they suitable for?
- at the time of periods , Do not regulate cycles | Suitable for those trying to conceive or avoiding hormones
43
What does LNG IUS (Mirena) and depo-provera do?
reduces bleeding – may cause irregular bleeding, some women will be amenorrhoeic
44
oral progestogens eg provera 10mg - when can it be given?
day 5-25 cycle reduce bleeding +regulate - day 15-25 may regulate cycle but does not reduce amount of bleeding
45
Surgical Treatments - endometrial ablation
Permanent destruction of endometrium using different energy sources
46
what does first generation ablation under hysteroscopic vision use?
diathermy
47
what does second generation ablation use?
thermal balloon, radio frequency
48
cervix removed or reserved in hysterectomy - what are they called?
Total hysterectomy: cervix and uterus removed Subtotal hysterectomy: uterus removed, cervix left
49
ovaries and tubes removed called?
sapling-oophorectomy
50
risks of hysterectomy?
infection, DVT BLADDER/BOWEL/ VESSEL INJURY | - altered bladder function / adhesions
51
Ovaries may be removed with uterus in women with?
endometriosis or presence of ovarian pathology
52
Disadvantages of oophorectomy?
immediate menopause – recommended HRT till age 50
53
Advantages of oophorectomy?
Reduces risk of subsequent ovarian cancer
54
Oligo/amennorhea?
infrequent, absent or abnormally light menstruation
55
causes of amennorhea?
Life changes:stress, eating disorders/malnourishment, obesity, Intense exercise
56
hormones that may cause amennorhoea - what may they have?
POP, mirena , depot injection prim ovarian insufficiency
57
what to look for with amennorhoea - underlying causes (4)
- Hyperprolactinemia (elevated levels of prolactin in the blood) - Prolactinomas (adenomas on the anterior pituitary gland) - Thyroid disorders (Graves’s disease) - Obstructions of the uterus, cervix, and/or vagina Investigate and treat the cause
58
Polycystic Ovary Syndrome is a ?
Metabolic syndrome with diagnosis confirmed if 2 of 3 criteria met
59
criteria for Polycystic Ovary Syndrome? (3)
- Ultrasound appearance of ovary - Biochemical hyperandrogenism - Clinical hyperandrogenism with oligomenorrhoea ,hirsuitism, acne, infertility and obesity
60
Polycystic Ovary Syndrome? can result in?
oligo menorrhea /amenorrhea
61
management of Polycystic Ovary Syndrome?
includes lifestyle adjustment with aim to achieve normal BMI
62
Polycystic Ovary Syndrome? - how man withdrawal bleeds do they need and why? - how is this achieved ?
3 - to prevent hyperplasia or endometrial protection COCP,POP, mirena IUS or norethisterone
63
What is Dysfunctional Uterine bleeding?
excessive uterine bleeding | - affects premenopausal women that is not due to pregnancy or any recognisable uterine or systemic diseases.
64
Dysfunctional Uterine bleeding - the underlying pathophysiology is believed to be due to?
ovarian hormonal dysfunction
65
Dysfunctional Uterine bleeding - GnRh analogues are good for?
bridging for patients who are nearly menopausal - the have declined other options
66
How do GnRh analogues work?
ant estrogen and produce a pseudo menopause .
67
6 month therapy is needed for?
dysfunctional uterine bleeding | - should get add back HRT until they are confirmed menopausal