Menstrual Cycle Flashcards

1
Q

what is primary amenorrhoea

A

the failure to establish menstruation by 16 years old

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2
Q

what is secondary amenorrhoea

A

stopping of a previously normal menstruation for over 6 months

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3
Q

what is oligomenorrhoea

A

infrequent menstruation

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4
Q

what is menorrhagia

A

excessive menstrual loss

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5
Q

how to fibroids cause menorrhagia

A

by increasing the surface area

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6
Q

what are common causes for menorrhagia

A

fibroids, polyps, endometrial cancer, bleeding disorders

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7
Q

what is dysmenorrhoea

A

pain during menstruation

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8
Q

what is endometriosis

A

growth of plaques made of endometrium growing outside of the uterus

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9
Q

what can you give to treat endometriosis

A

GnRH against - this will desensitise the GnRH receptors to switch off the HPG axis and so oestrogen won’t be produced to help the plaques grow

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10
Q

why are GnRH agonists not good for long term treatment

A

the lack of oestrogen produced can cause osteoporosis

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11
Q

what are the 2 layers which make up the endometrium

A
  1. functional layer

2. basal layer

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12
Q

what is the functional layer of the endometrium

A

the hormone responsive layer which grows and sheds if fertilisation doesn’t occur

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13
Q

what is the basal layer of the endometrium

A

the cells that grow to give the functional layer

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14
Q

true or false: low levels of oestrogen cause a positive feedback response

A

false

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15
Q

true or false: high levels of oestrogen cause a positive feedback response

A

true

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16
Q

is there a positive or negative feedback mechanism in the presence of oestrogen and progesterone

17
Q

how can progesterone be used in a contraceptive pill

A

thickens the cervical mucus to prevent sperm from entering

18
Q

at the start of the cycle, what does a rise in FSH cause

A

follicular development

19
Q

what cells does the FSH bind to

A

granulose cells

20
Q

what will the follicle begin secreting when it has matured

A

oestrogen and inhibin

21
Q

after an initial increase in FSH, what causes the FSH levels to fall

A

the inhibin produced by the mature follicle

22
Q

what causes the LH surge

A

high levels of oestrogen produced from the follicle cause a positive feedback response, causing a large increase in LH

23
Q

what does the LH surge allow to happen

A

ovulation

for the follicle to finish meiosis 1 and start meiosis 2

24
Q

what is left in the ovary after ovulation

A

corpus luteum

25
what hormones does the corpus lutuem produce
oestrogen and progesteorne and inhibin
26
why do the LH and FSH levels decrease after ovulation
the oestrogen and progesterone released by the corpus luteum cause a negative feedback response inhibin also prevents FSH production
27
what happens if fertilisation occurs
HCG is produced which has the same effect as LH
28
where is HCG produced from
syncytiotrophoblast
29
what do FSH and LH do
cause follicular development and ovulation as well as the release of oestrogen
30
what happens to the initial levels of LH and FSH in menopause
they increase