Meningitis Flashcards by Ellen Schafer

Q

most likely cause of meningitis in newborns

A

E. coli
Klebsiella spp.
Group B Streptococcus
Enterobacter spp.

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Q

most likely cause of meningitis 1 month-29 years

A

N. meningitis
S. pneumoniae
H. influenzae

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Q

most likely cause of meningitis 30-70 yrs

A

S. pneumoniae

N. meningitidis

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Q

cotrimoxazole penetration

A

penetrates without inflammation

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Q

chloramphenicol penetration

A

penetrates without inflammation

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Q

isoniazid/rifampin penetration

A

penetrates without inflammation

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Q

linezolid penetration

A

penetrates without inflammation

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Q

ampicillin penetration

A

penetrates with inflammation

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Q

aztreonam penetration

A

penetrates with inflammation

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Q

cefotaxime penetration

A

penetrates with inflammation

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Q

ceftazadime penetration

A

penetrates with inflammation

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Q

cefuroxime penetration

A

penetrates with inflammation

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Q

ciprofloxacin penetration

A

penetrates with inflammation

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Q

levofloxacin penetration

A

penetrates with inflammation

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Q

imipenem/meropenem penetration

A

penetrates with inflammation

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Q

penicillin G penetration

A

penetrates with inflammation

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Q

piperacillin penetration

A

penetrates with inflammation

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Q

ticarcillin penetration

A

penetrates with inflammation

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Q

doxycycline penetration

A

penetrates with inflammation

Q

vancomycin penetration

A

penetrates with inflammation

Q

tetracycline penetration

A

penetrates with inflammation

Q

tigecyclines penetration

A

penetrates with inflammation

Q

aminoglycoside penetration

A

do not penetrate

Q

macrolides penetration

A

do not penetrate

ketolides penetration

do not penetrate

clindamycin penetration

do not penetrate

cefazolin penetration

do not penetrate

first gen cephalosporin penetration

do not penetrate

neonate meningitis empiric therapy

ampicillin + 3rd gen cephalosporin + vancomycin

3-50 yrs meningitis empiric therapy

3rd gen cephalosporin + vancomycin

>50 yrs meningitis empiric therapy

ampicillin + 3rd gen cephalosporin + vancomycin

S. pneumoniae drug of choice

penicillin G

S. pneumoniae alternatives

ceftriaxone, cefotaxime, cefuroxime, chloramphenicol, vancomycin

PRSP therapy

vancomycin + rifampin, quinolone, linezolid

H. influenzae beta-lactamase negative drug of choice

ampicillin

H. influenzae beta-lactamase positive drug of choice

ceftriaxone

H. influenzae alternatives

chloramphenicol, cotrimoxazole, fluoroquinolone

N. meningitidis drug of choice

penicillin G

N. meningitidis alternatives

ceftriaxone, chloramphenicol, fluoroquinolone

Group B Strep drug of choice

penicillin G

Group B Strep alternatives

ceftriaxone, chloramphenicol, cotrimoxazole

Listeria monocytogenes drug of choice

ampicillin

Listeria monocytogenes alternatives

cotrimoxazole, linezolid

ceftriazone dosing

2 gm q12hr or 4 gm q24hr IVPB

dexamethasone dosing

15 mg/kg q6hr for 2 days

H. influenzae and N. meningitidis prophylaxis

rifampin