Meningitis Flashcards by Ellen Schafer | Brainscape

Q

most likely cause of meningitis in newborns

A

E. coli
Klebsiella spp.
Group B Streptococcus
Enterobacter spp.

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Q

most likely cause of meningitis 1 month-29 years

A

N. meningitis
S. pneumoniae
H. influenzae

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Q

most likely cause of meningitis 30-70 yrs

A

S. pneumoniae

N. meningitidis

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Q

cotrimoxazole penetration

A

penetrates without inflammation

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Q

chloramphenicol penetration

A

penetrates without inflammation

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Q

isoniazid/rifampin penetration

A

penetrates without inflammation

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Q

linezolid penetration

A

penetrates without inflammation

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Q

ampicillin penetration

A

penetrates with inflammation

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Q

aztreonam penetration

A

penetrates with inflammation

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Q

cefotaxime penetration

A

penetrates with inflammation

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Q

ceftazadime penetration

A

penetrates with inflammation

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Q

cefuroxime penetration

A

penetrates with inflammation

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Q

ciprofloxacin penetration

A

penetrates with inflammation

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Q

levofloxacin penetration

A

penetrates with inflammation

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Q

imipenem/meropenem penetration

A

penetrates with inflammation

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Q

penicillin G penetration

A

penetrates with inflammation

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Q

piperacillin penetration

A

penetrates with inflammation

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Q

ticarcillin penetration

A

penetrates with inflammation

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Q

doxycycline penetration

A

penetrates with inflammation

Q

vancomycin penetration

A

penetrates with inflammation

Q

tetracycline penetration

A

penetrates with inflammation

Q

tigecyclines penetration

A

penetrates with inflammation

Q

aminoglycoside penetration

A

do not penetrate

Q

macrolides penetration

A

do not penetrate

Q

ketolides penetration

A

do not penetrate

Q

clindamycin penetration

A

do not penetrate

Q

cefazolin penetration

A

do not penetrate

Q

first gen cephalosporin penetration

A

do not penetrate

Q

neonate meningitis empiric therapy

A

ampicillin + 3rd gen cephalosporin + vancomycin

Q

3-50 yrs meningitis empiric therapy

A

3rd gen cephalosporin + vancomycin

Q

> 50 yrs meningitis empiric therapy

A

ampicillin + 3rd gen cephalosporin + vancomycin

Q

S. pneumoniae drug of choice

A

penicillin G

Q

S. pneumoniae alternatives

A

ceftriaxone, cefotaxime, cefuroxime, chloramphenicol, vancomycin

Q

PRSP therapy

A

vancomycin + rifampin, quinolone, linezolid

Q

H. influenzae beta-lactamase negative drug of choice

A

ampicillin

Q

H. influenzae beta-lactamase positive drug of choice

A

ceftriaxone

Q

H. influenzae alternatives

A

chloramphenicol, cotrimoxazole, fluoroquinolone

Q

N. meningitidis drug of choice

A

penicillin G

Q

N. meningitidis alternatives

A

ceftriaxone, chloramphenicol, fluoroquinolone

Q

Group B Strep drug of choice

A

penicillin G

Q

Group B Strep alternatives

A

ceftriaxone, chloramphenicol, cotrimoxazole

Q

Listeria monocytogenes drug of choice

A

ampicillin

Q

Listeria monocytogenes alternatives

A

cotrimoxazole, linezolid

Q

ceftriazone dosing

A

2 gm q12hr or 4 gm q24hr IVPB

Q

dexamethasone dosing

A

15 mg/kg q6hr for 2 days

Q

H. influenzae and N. meningitidis prophylaxis

A

rifampin