Exam 3 Boncher

Question 1

sulfa drug MOA

Answer 1

inhibit dihydropteroate synthase

Question 2

sulfa drug PC

Answer 2

C (except sulfasalazine B)

Question 3

trimethoprim MOA

Answer 3

inhibits dihydrofolate reductase

Question 4

sulfisoxazole + erythromycin use

Answer 4

H. flu ear infection

Question 5

sulfacetamide use

Answer 5

opthalmic drops, seborrheic dermatitis, acne

Question 6

sulfasalazine use

Answer 6

IBD- UC/Crohns

Question 7

Bactrim use

Answer 7

chronic bronchitis, sepsis, shigellosis, travelers diarrhea, UTI, CA-MRSA

Question 8

Bactrim spectrum of activity

Answer 8

strep, staph, E. coli, H. flu, toxoplasmosis

Question 9

sulfanilamide use

Answer 9

C. albicans vulvovaginitis

Question 10

sulfadiazine use

Answer 10

topical for burns PO for toxoplasmosis

Question 11

metronidazole PC

Answer 11

B, not in 1st trimester

Question 12

metronidazole use

Answer 12

anaerobic bacterial infections, intraabdominal infections, C. diff, septicemia, amebiasis

Question 13

metronidazole spectrum

Answer 13

bacteroides, fusobacterium, clostridium, peptococcus, entamoeba histolytica, trichomonas

Question 14

metronidazole MOA

Answer 14

inhibit nucleic acid synthesis

Question 15

daptomycin PC

Answer 15

B

Question 16

daptomycin spectrum

Answer 16

S. auries, S. pyogenes, S. agalactiae, Enterococcus faecalis

Question 17

daptomycin MOA

Answer 17

bind bacterial membranes to cause rapid depolarization leading to inhibiton of protein, DNA, and RNA synthesis

Question 18

linezolid PC

Answer 18

C

Question 19

linezolid spectrum

Answer 19

strep, S. aureus, enterococcus faecium

Question 20

linezolid MOA

Answer 20

inhibits protein synthesis by binding 23S rRNA on 50S subunit to prevent formation of 70S initiation complex

Question 21

clindamycin PC

Answer 21

B

Question 22

clindamycin spectrum

Answer 22

MSSA, strep, C. perfringens, Prevotella, fusobacterium, peptostreptococcus, plasmodium

Question 23

clindamycin MOA

Answer 23

binds 50S subunit to inhibit protein synthesis

Question 24

nitrofurantoin PC

Answer 24

B

Question 25

nitrofurantoin activity

Answer 25

UTI- E. coli, klebsiella, enterobacter, staph

Question 26

nitrofurantoin MOA

Answer 26

inactivates bacterial ribosomes for protein, DNA, RNA, CW synthesis

Question 27

Synercid PC

Answer 27

B

Question 28

Synercid activity

Answer 28

S. aureus, S. pyogenes, Enterococcus faecium

Question 29

Synercid MOA

Answer 29

bind 70S subunit at A and P sites causing misalignment of tRNA in P site to inhibit protein synthesis

Question 30

vancomycin PC

Answer 30

C

Question 31

vancomycin activity

Answer 31

enterococci, staph, listeria, strep, actinomyces, lactobacillus

Question 32

vanco MOA

Answer 32

inhibit cell wall syn by preventing transpeptidation and glycosylation

Question 33

telavancin PC

Answer 33

C

Question 34

telavancin MOA

Answer 34

inhibits cell wall synthesis by preventing cross linking

Question 35

telavancin activity

Answer 35

s. aurues, strep, entercoccus faecalis

Question 36

tinidazole PC

Answer 36

c

Question 37

tinidazole activity

Answer 37

amebiasis, bacterial vaginosis, giardiasis, tricomoniasis

Question 38

tinidazole MOA

Answer 38

generates free radicals that damage DNA

Question 39

chloramphenicol PC

Answer 39

C

Question 40

chloramphenicol activity

Answer 40

thyphoid fever, H. flu, rickettsia

Question 41

chloramphenicol MOA

Answer 41

bind 50S subunit to inhibit protein synthesis