Membrane fusion Flashcards
1
Q
How is membrane fusion mediated?
A
Fusion proteins
2
Q
What are SNAREs?
A
Vesicle fusion proteins
3
Q
What are the two types of SNAREs?
A
V-SNAREs and T-SNAREs
4
Q
Where are V-SNAREs found? What are they called in neurons?
A
Vesicle membranes. Also called synaptobrevin in neurons or VAMP
5
Q
Where are T-SNAREs found? What are they called in neurons?
A
Target membranes. Also called syntaxin in neurons
6
Q
How do SNAREs cause membrane fusion?
A
Each one has two helices outside the membrane. They make contact, coil up and pull the membranes together. Causes a local disruption in the membrane and the membranes fuse
7
Q
Which neurotoxins target SNAREs?
A
Botulinum and Tetanus. They’re both proteases
