Membrane Channels And Pumps Flashcards
What is the Na/K ATPase (or Na/K exchanger)?
Primary active. Enables chemical gradient. Allows and starts metabolic pathways.
What is the primary active transporter of the P-type family?
SERCA calcium pump
Hydrophobic compounds often have active transporters. TF
False: can cross cell membrane. Semi permeable.
Describe a SERCA calcium pump?
SERCA are located inside of the cell. A P and N domains. A for actuator, conformation change. P type (bind phosphate) and ATPase (use ATP). N domain get close to A domain during conformation change, this opens it up for the calcium to release. Closed is active. Cannot accept calcium
Give an example of secondary active transport
Glucose using sodium pump channels.
What is a passive transporter
A channel that opens at plasma membrane and nutrients move down gradient. Energy comes from concentration gradient.
Primary active transport involves the hydrolysis of ATP. TF
True: energy is needed to move across a concentration gradient.
Describe a glucose transporter?
Secondary active transport. Energy would be required because more glucose is in the cell. Opportunistic transport. Glucose tags along with sodium to move into cell. Simporter.
Give an example of an active pump and a P-loop family member.
Na/K ATPase and ABC. Primary active transport.
What is a lactose permease?
Secondary transport. Protons move into the cell (down gradient). Lactose goes against gradient. (Opportunistic).
Describe the Na/K ATPase (or Na/K exchanger or pump).
Primary active. Uses membrane potential. ATP hydrolysis to pump Na+ out of the cell and K+ into the cell
Passive transport moves things according to an established gradient. TF
True
What is an ABC (or MDR) transporter?
MDR = Multi Drug Resistance. Causes resistance to cancer therapies. Removes toxins from the cell. Primary transport.
The energy for _______ transport comes from the gradient itself.
Passive.
Which of the following is a good example of primary active transport?
Calcium channels.
