Meh metabolism Flashcards

1
Q

Vit C (ascorbic acid) deficiency leads to

A

scurvy

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2
Q

Vitamin B1 (thiamin) deficiency leads to

A

beriberi

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3
Q

Vitamin B2 (riboflavin) deficiency leads to

A

ariboflavinosis

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4
Q

Vitamin B3 (niacin) deficiency leads to

A

pellagra

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5
Q

Vitamin B6 deficiency leads to

A

dermatitis, anaemia

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6
Q

Vitamin B12 deficiency leads to

A

anaemia

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7
Q

Maltose is made up of

A

glucose glucose

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8
Q

Sucrose is made up of

A

glucose fructose

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9
Q

Desirable BMI

A

18.5-24.9

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10
Q

How much fluids is needed

A

1mmol/kg/day

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11
Q

Which amino acids are conditionally essential during periods of high protein synthesis

A

arginine, tyrosine and cysteine

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12
Q

What is selenium

A

Trace element needed as cofactor for glutathione peroxidase to protect against oxidative stress

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13
Q

What is used in the first seconds of vigorous exercise

A

phosphocreatine

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14
Q

NADH supplies

A

ETC (DNP = uncoupler), high energy signal

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15
Q

What converts glucose to G6P

A

hexokinase

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16
Q

Glycolysis occurs in

A

cytosol

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17
Q

What converts DHAP to glycerol phosphate

A

glycerol 3-P dehydrogenase in adipose and liver

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18
Q

RBCs use

A

LDH reaction

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19
Q

Pyruvate is converted to acetyl CoA by

A

PDH

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20
Q

Krebs cycle produces

A

NADH and FADH2

21
Q

Kinase =

A

phosphorylators

22
Q

After phosphorylation, glycerol can

A

enter glycolysis

23
Q

Why do lipids have higher energy content

A

more reduced

24
Q

which vitamins are free radical scavengers

A

C and E

25
Q

What is galactosaemia

A

GALT deficiency

26
Q

What is glutathione

A

anti oxidant against NAPQI

27
Q

What converts H2O2 to water and oxygen

A

SOD and catalase

28
Q

NAD + goes to what in alcohol metabolism

A

NADH

29
Q

source of free radicals

A

nitric oxide synthase

30
Q

Alanine is utilised for

A

transport of ammonia to liver

31
Q

Creatinine is used to monitor

A

muscle mass and renal function

32
Q

Tyrosine is a precursor for

A

catecholamines

33
Q

Vit B6 is given for

A

homocystinuria

34
Q

PKU is

A

phenylalanine hydroxylase deficiency

35
Q

Fatty acid synthesis occurs

A

in cytoplasm

36
Q

Acetyl-CoA carboxylase produces

A

malonyl CoA from Acetyl CoA

37
Q

Hormone sensitive lipase breaks down

A

triacylglycerol into fatty acids and glycerol

38
Q

Insuline stimulates

A

fatty acid synthesis via dephosphorylation of acetyl-CoA carboxylase

39
Q

Muscles lack

A

glucose-6-phosphatase

40
Q

What is the rate limiting enzyme in glycogen synthesis

A

Glycogen synthase

41
Q

ApoA-1 deficiency inhibits

A

Nascent HDL synthesis

42
Q

FA are converted to

A

acetyl CoA by beta oxidation, then Krebs cycle

43
Q

Ideal cholesterol

A

Less than 5mmol/L

44
Q

ABCA1 facilitates

A

XS cholesterol transfer to HDL

45
Q

What has highest cholesterol content

A

LDL

46
Q

Cholesterol is converted to

A

cholesterol ester by LCAT

47
Q

Type 1 deficiency =

A

lipoprotein lipase defective

48
Q

Type 2A deficiency

A

LDL receptor

49
Q

Type 3 deficiency

A

ApOE