MCBG Quiz Qs

Question 1

Which haem protein has a higher affinity for oxygen out of myoglobin and haemoglobin

Answer 1

Myoglobin

Question 2

What joins DNA strands together

Answer 2

DNA ligase

Question 3

Main function of RER

Answer 3

Synthesis of proteins destined for the lysosomes, the cell membrane and transport extracellularly

Question 4

By what property does gel electrophoresis separate DNA fragments

Answer 4

By size

Question 5

What is the overall charge of a DNA molecule

Answer 5

Negative - due to phosphate group

Question 6

What is the sequence of proteins produced in synthesis of collagen

Answer 6

Procollagen, Tropocollagen, Collagen

Question 7

Which organelle does the formation of disulphide bonds take place in

Answer 7

Endoplasmic reticulum

Question 8

In meiosis, when must non-disjunction occur for there to be any normal gametes

Answer 8

Meiosis 2 (2 normal cells, 1 trisomy and 1 monosomy)

Question 9

What is TATA box

Answer 9

DNA sequence that indicates where a genetic sequence can be read and decoded, type of promoter sequence, TATAAA

Question 10

What is it called when a large part of a chromosome is swapped with a large part of another chromosome

Answer 10

Translocation

Question 11

Which repair mechanism is defective in HNPCC

Answer 11

DNA mismatch repair

Question 12

Where on a graph would -1/Km be determined

Answer 12

X intercept

Question 13

What are the only sulphur containing amino acids incorporated into proteins

Answer 13

Methionine and cysteine

Question 14

What it mitotic spindle formed from

Answer 14

Microtubules which are polymers of the protein tubulin

Question 15

What to remember about identical twins in genetics

Answer 15

Have identical DNA so could be considered as one individual

Question 16

Transmissible spongiform encephalopathies are caused by abnormal folding of

Answer 16

Prions

Question 17

What misfolding is associated with Alzheimer’s disease

Answer 17

Amyloid Beta

Question 18

What misfolding is associated with Amyotrophic lateral sclerosis

Answer 18

Superoxide dismutase

Question 19

What folding is associated with Alzheimer’s disease and Frontotemporal dementia with Parkinson’s

Answer 19

Tau

Question 20

Which 3 amino acids have an aromatic side chain

Answer 20

Tyrosine, tryptophan and phenylalanine

Question 21

What is pKa

Answer 21

pH at which there is an equal concentration of the protonated/deprotonated species

Question 22

How many bases per turn in double helix of DNA

Answer 22

10

Question 23

Disulphide bonds are formed between

Answer 23

Cysteine residues

Question 24

What happens in G1

Answer 24

All cellular contents excluding chromosomes are duplicated

Question 25

At what end are most mRNA molecules polyadenlyated

Answer 25

3’

Question 26

What do zymogen granules look like down a microscope

Answer 26

Black circle

Question 27

What is the smallest repetitive element in chromatin

Answer 27

Nucleosome

Question 28

Which process is defective in xeroderma pigmentosum where UV damage is repaired

Answer 28

Nucleotide excision repair

Question 29

Salt bridges form between

Answer 29

Oppositely charged residues e.g. glutamic acid and lysine (hydrogen bonding and ionic bonding)