MCBG Quiz Qs Flashcards
Which haem protein has a higher affinity for oxygen out of myoglobin and haemoglobin
Myoglobin
What joins DNA strands together
DNA ligase
Main function of RER
Synthesis of proteins destined for the lysosomes, the cell membrane and transport extracellularly
By what property does gel electrophoresis separate DNA fragments
By size
What is the overall charge of a DNA molecule
Negative - due to phosphate group
What is the sequence of proteins produced in synthesis of collagen
Procollagen, Tropocollagen, Collagen
Which organelle does the formation of disulphide bonds take place in
Endoplasmic reticulum
In meiosis, when must non-disjunction occur for there to be any normal gametes
Meiosis 2 (2 normal cells, 1 trisomy and 1 monosomy)
What is TATA box
DNA sequence that indicates where a genetic sequence can be read and decoded, type of promoter sequence, TATAAA
What is it called when a large part of a chromosome is swapped with a large part of another chromosome
Translocation
Which repair mechanism is defective in HNPCC
DNA mismatch repair
Where on a graph would -1/Km be determined
X intercept
What are the only sulphur containing amino acids incorporated into proteins
Methionine and cysteine
What it mitotic spindle formed from
Microtubules which are polymers of the protein tubulin
What to remember about identical twins in genetics
Have identical DNA so could be considered as one individual
Transmissible spongiform encephalopathies are caused by abnormal folding of
Prions
What misfolding is associated with Alzheimer’s disease
Amyloid Beta
What misfolding is associated with Amyotrophic lateral sclerosis
Superoxide dismutase
What folding is associated with Alzheimer’s disease and Frontotemporal dementia with Parkinson’s
Tau
Which 3 amino acids have an aromatic side chain
Tyrosine, tryptophan and phenylalanine
What is pKa
pH at which there is an equal concentration of the protonated/deprotonated species
How many bases per turn in double helix of DNA
10
Disulphide bonds are formed between
Cysteine residues
What happens in G1
All cellular contents excluding chromosomes are duplicated
At what end are most mRNA molecules polyadenlyated
3’
What do zymogen granules look like down a microscope
Black circle
What is the smallest repetitive element in chromatin
Nucleosome
Which process is defective in xeroderma pigmentosum where UV damage is repaired
Nucleotide excision repair
Salt bridges form between
Oppositely charged residues e.g. glutamic acid and lysine (hydrogen bonding and ionic bonding)
