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meds; cardiac Flashcards

1
Q

ephedrine dose

A

5 mg

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2
Q

ephedrine concentration

A

50mg/ml

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3
Q

Ephedrine MOA

A

indirect sympatomimetic ; release stored NE

increase CAMP -> Ca+ influx -> actin/ myosin interaction

increase CO and HR(alpha and beta)

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4
Q

Ephedrine side effects

A

tachyphylaxis (depletes stored NE)

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5
Q

neosynephrine dose

A

100 mcg

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6
Q

neosynephrine concetration

A

10 mg/ ml

** pay attention to concentration!!

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7
Q

neosynephrine MOA

A

alpha agonist

venous constriction > arterial constriction
mimics NE but lasts longer/ less potent

decrease hr,
increase bp
co varries
increase SVR
increase PVR

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8
Q

Neosynepherine Side effects

A

reflex bradycardia because increase svr -> sensors in carotid/ aortic arch to decrease CO in response to the inc bp by increasing vagal tone

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9
Q

Labetalol dose

A

5 mg

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10
Q

Labetalol concentration

A

5 mg/ml

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11
Q

Labetalol mode of action

A

non selective beta antagonist > alpha antagonist (7:1)

decreased svr, reflex tachycardia attenuated because of beta

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12
Q

Labetalol side effects

A

tachyphylaxis

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13
Q

Esmolol dose

A

10 mg
or 0.5 mg/kg

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14
Q

Esmolol concentration

A

10 mg/ml

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15
Q

Esmolol Gtt dose

A

50 mcg/kg/min

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16
Q

Esmolol trade name

A

brevibloc

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17
Q

Esmolol MOA

A

Beta 1 selective antagonist

prolong phase 4 of the myocardium; increase the diastolic time

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18
Q

Esmolol metabolism

A

cleared w/ plasma hydrolysis plasma esterase in the cytosol

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19
Q

Esmolol 1/2 life

A

15 min

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20
Q

Esmolol side effects

A

Cocaine/ epi absorption + esmolol -> pulmonary edema/ collapse

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21
Q

Hydralazine dose

A

5 mg

remember long onset!

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22
Q

hydralazine concentration

A

20 mg/ml

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23
Q

hydralazine MOA

A

arterial vasodilator by decreasing IP3 decreases calcium release in smm

24
Q

Hydralazine side effects

A

rebound tachycardia

25
Q

Metoprolol dose

26
Q

Metoprolol MOA

A

Selective Beta 1 antagonist

27
Q

Beta 1 selective antagonist side effects with DM pts

A

interferes w/ gluconeogeneissi and potentiates insulin

28
Q

Beta 1 selective blockers effects on K

A

increase plasma K+ because it decreases na/k cycling

29
Q

Nitroglycerine gtt dose

A

5-10 mcg/ min

30
Q

nitroglycerine bolus dose

A

50-200 mcg

31
Q

Sodium Nitropurriside gtt dose

A

0.3mcg/kg/min-2mcg/kg/min

32
Q

SNP bolus dose

A

50-200 mcg

33
Q

Phenylephrine gtt dose

A

0.1-0.7 mcg/kg/min

34
Q

Epinephrine bolus dose

35
Q

Epi gtt dose

A

0.01-0.2 mcg/kg/min

36
Q

Norepi bolus dose

37
Q

Norepi gtt dose

A

0.01-0.2 mcg/kg/min

38
Q

Vasopressin gtt dose

A

0.01-0.2 units/min

39
Q

Vasopressin bolus dose

40
Q

What medication is used to reverse catecholamine resistance

A

vasopressin

41
Q

Vasopressin MOA

A

ADH
V1>V2

V1 = increase water reabsoprtion

42
Q

Calcium chloride dose

A

250-1000 mg

43
Q

Calcium chloride MOA

A

inoppressor

increase ca concentration = increase gradient for ca to enter smm and cardiac cells = increase contraction / bp

44
Q

Dobutamine gtt dose

A

2-20 mcg/kg/min

45
Q

Dobutamine MOA

A

Selective beta 1 agonist

increase hr, increase co, decrease svr, decrease pvr

46
Q

Isoproterenol gtt dose

A

1-20 mcg/ min

47
Q

Isoproterenol moa

A

Beta agonist

vasodilate coronary arteries

48
Q

Milrinone bolus Dose

A

25-50mcg/kg

49
Q

Milrinone gtt dose

A

0.125-0.75 mcg/kg/min

50
Q

Milrinone MOA

A

heart = PDE3 inhibitor = increase CAMP = increase contraction

periphery= increase cGMP = increase PKG = + MLCP activity and inhibits ca influx

51
Q

tachycardiac and normal hr and hypertensive give…

52
Q

tachycardiac and hypertensive or just tachycardic give….

53
Q

bradycardic and hypertensive give….

A

hydralazine

54
Q

Diltiazem dose

55
Q

Diltiazem moa

A

non DHP CCB

decrease bp and co

56
Q

Verapamil dose

A

2.5 -10 mg

57
Q

Verapamila moa

A

non dhp ccb ; dec hr dec bp and dec CO

Clinical prep (21 decks)

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