meds; cardiac Flashcards
ephedrine dose
5 mg
ephedrine concentration
50mg/ml
Ephedrine MOA
indirect sympatomimetic ; release stored NE
increase CAMP -> Ca+ influx -> actin/ myosin interaction
increase CO and HR(alpha and beta)
Ephedrine side effects
tachyphylaxis (depletes stored NE)
neosynephrine dose
100 mcg
neosynephrine concetration
10 mg/ ml
** pay attention to concentration!!
neosynephrine MOA
alpha agonist
venous constriction > arterial constriction
mimics NE but lasts longer/ less potent
decrease hr,
increase bp
co varries
increase SVR
increase PVR
Neosynepherine Side effects
reflex bradycardia because increase svr -> sensors in carotid/ aortic arch to decrease CO in response to the inc bp by increasing vagal tone
Labetalol dose
5 mg
Labetalol concentration
5 mg/ml
Labetalol mode of action
non selective beta antagonist > alpha antagonist (7:1)
decreased svr, reflex tachycardia attenuated because of beta
Labetalol side effects
tachyphylaxis
Esmolol dose
10 mg
or 0.5 mg/kg
Esmolol concentration
10 mg/ml
Esmolol Gtt dose
50 mcg/kg/min
Esmolol trade name
brevibloc
Esmolol MOA
Beta 1 selective antagonist
prolong phase 4 of the myocardium; increase the diastolic time
Esmolol metabolism
cleared w/ plasma hydrolysis plasma esterase in the cytosol
Esmolol 1/2 life
15 min
Esmolol side effects
Cocaine/ epi absorption + esmolol -> pulmonary edema/ collapse
Hydralazine dose
5 mg
remember long onset!
hydralazine concentration
20 mg/ml