meds; cardiac

Question 1

ephedrine dose

Answer 1

5 mg

Question 2

ephedrine concentration

Answer 2

50mg/ml

Question 3

Ephedrine MOA

Answer 3

indirect sympatomimetic ; release stored NE

increase CAMP -> Ca+ influx -> actin/ myosin interaction

increase CO and HR(alpha and beta)

Question 4

Ephedrine side effects

Answer 4

tachyphylaxis (depletes stored NE)

Question 5

neosynephrine dose

Answer 5

100 mcg

Question 6

neosynephrine concetration

Answer 6

10 mg/ ml

** pay attention to concentration!!

Question 7

neosynephrine MOA

Answer 7

alpha agonist

venous constriction > arterial constriction
mimics NE but lasts longer/ less potent

decrease hr,
increase bp
co varries
increase SVR
increase PVR

Question 8

Neosynepherine Side effects

Answer 8

reflex bradycardia because increase svr -> sensors in carotid/ aortic arch to decrease CO in response to the inc bp by increasing vagal tone

Question 9

Labetalol dose

Answer 9

5 mg

Question 10

Labetalol concentration

Answer 10

5 mg/ml

Question 11

Labetalol mode of action

Answer 11

non selective beta antagonist > alpha antagonist (7:1)

decreased svr, reflex tachycardia attenuated because of beta

Question 12

Labetalol side effects

Answer 12

tachyphylaxis

Question 13

Esmolol dose

Answer 13

10 mg
or 0.5 mg/kg

Question 14

Esmolol concentration

Answer 14

10 mg/ml

Question 15

Esmolol Gtt dose

Answer 15

50 mcg/kg/min

Question 16

Esmolol trade name

Answer 16

brevibloc

Question 17

Esmolol MOA

Answer 17

Beta 1 selective antagonist

prolong phase 4 of the myocardium; increase the diastolic time

Question 18

Esmolol metabolism

Answer 18

cleared w/ plasma hydrolysis plasma esterase in the cytosol

Question 19

Esmolol 1/2 life

Answer 19

15 min

Question 20

Esmolol side effects

Answer 20

Cocaine/ epi absorption + esmolol -> pulmonary edema/ collapse

Question 21

Hydralazine dose

Answer 21

5 mg

remember long onset!

Question 22

hydralazine concentration

Answer 22

20 mg/ml

Question 23

hydralazine MOA

Answer 23

arterial vasodilator by decreasing IP3 decreases calcium release in smm

Question 24

Hydralazine side effects

Answer 24

rebound tachycardia

Question 25

Metoprolol dose

Answer 25

1-15 mg

Question 26

Metoprolol MOA

Answer 26

Selective Beta 1 antagonist

Question 27

Beta 1 selective antagonist side effects with DM pts

Answer 27

interferes w/ gluconeogeneissi and potentiates insulin

Question 28

Beta 1 selective blockers effects on K

Answer 28

increase plasma K+ because it decreases na/k cycling

Question 29

Nitroglycerine gtt dose

Answer 29

5-10 mcg/ min

Question 30

nitroglycerine bolus dose

Answer 30

50-200 mcg

Question 31

Sodium Nitropurriside gtt dose

Answer 31

0.3mcg/kg/min-2mcg/kg/min

Question 32

SNP bolus dose

Answer 32

50-200 mcg

Question 33

Phenylephrine gtt dose

Answer 33

0.1-0.7 mcg/kg/min

Question 34

Epinephrine bolus dose

Answer 34

5-10 mcg

Question 35

Epi gtt dose

Answer 35

0.01-0.2 mcg/kg/min

Question 36

Norepi bolus dose

Answer 36

5-10 mcg

Question 37

Norepi gtt dose

Answer 37

0.01-0.2 mcg/kg/min

Question 38

Vasopressin gtt dose

Answer 38

0.01-0.2 units/min

Question 39

Vasopressin bolus dose

Answer 39

1-2 units

Question 40

What medication is used to reverse catecholamine resistance

Answer 40

vasopressin

Question 41

Vasopressin MOA

Answer 41

ADH V1>V2 V1 = increase water reabsoprtion

Question 42

Calcium chloride dose

Answer 42

250-1000 mg

Question 43

Calcium chloride MOA

Answer 43

inoppressor increase ca concentration = increase gradient for ca to enter smm and cardiac cells = increase contraction / bp

Question 44

Dobutamine gtt dose

Answer 44

2-20 mcg/kg/min

Question 45

Dobutamine MOA

Answer 45

Selective beta 1 agonist increase hr, increase co, decrease svr, decrease pvr

Question 46

Isoproterenol gtt dose

Answer 46

1-20 mcg/ min

Question 47

Isoproterenol moa

Answer 47

Beta agonist vasodilate coronary arteries

Question 48

Milrinone bolus Dose

Answer 48

25-50mcg/kg

Question 49

Milrinone gtt dose

Answer 49

0.125-0.75 mcg/kg/min

Question 50

Milrinone MOA

Answer 50

heart = PDE3 inhibitor = increase CAMP = increase contraction periphery= increase cGMP = increase PKG = + MLCP activity and inhibits ca influx

Question 51

tachycardiac and normal hr and hypertensive give...

Answer 51

labetalol

Question 52

tachycardiac and hypertensive or just tachycardic give....

Answer 52

esmolol

Question 53

bradycardic and hypertensive give....

Answer 53

hydralazine

Question 54

Diltiazem dose

Answer 54

5-20 mg

Question 55

Diltiazem moa

Answer 55

non DHP CCB decrease bp and co

Question 56

Verapamil dose

Answer 56

2.5 -10 mg

Question 57

Verapamila moa

Answer 57

non dhp ccb ; dec hr dec bp and dec CO