meds; abx Flashcards
Penicillin MOA
inhibits cel wall synthesis
DOC for strep, meningococci and pneumonia cocci, mostly gram +, URI, catheter/ skin infections
Penicillin-Beta Lactam
Penicillin-Beta Lactam SE
resistance due to beta lactamse enzyme
hypersensitivity
GI upset
Vaginal candidas
Cefalosporin Beta lactams MOA
inhibits cell wall synthesis by binding to Pencicillin binding protein and inhibiting beta lactamaze
Cefalosporin Beta lactams use
surgical prophylaxis
mostly gram +
PCN allergy
doesn’t cross bbb
Cefalosporin Beta lactams SE
Production deficit of vitamin K
For true PCN anaphylaxis what meds should you use?
vanc or clindamycin
cefazolin trade name
ancef
cefuroxime trade name
ceftin
cefoxitin trade name
mefoxin
cefotetan trade name
cefotan
cefotaxime trade name
ciaforan
ceftriaxone trade name
rocephen
cefazidine trade name
foraz
cefepime trade name
maxipime
DOC for enterobacter
carbopenem
DOC with boradest spectrum activity
carbopenem
Carbopenem use
x bbb
last line agent for intrabdominal resistant, utis and pne
Carbopenem SE
dec depakote (valporic acid) up to 20%
lidocaine allergy (IM injection contains lido)
Vancomycin MOA
inhibits cell wall synethsis
beta lactamase resistant
Vancomycin use
Gram + works well if bacteria are actively binding
Blood stream infections
endocarditis caused by MRSA
Vanc SE
Red man syndrome
nephrotoxicity
phlembitis
chills/feverf
Aminoglycosides drug
gentamyacin
Aminoglycosides MOA
inhibits ribosomal proteins and causes mRNA to misread
Aminoglycosides USe
good post abx effect
synergistic w/ beta lactams and vanc
enterococcal endocardidtsi
Aminoglycosides SE
curare-like effect
ototoxicty
nephrotoxicity w/ loop dicuretics
ciproflaxacin and levoflaxacin are what type of meds
floroquinolone
floroquinolone MOA
inhibits DNA proteins synthesis
floroquinolone USE
Gram negative organisms
UTI, bacterial diarrhea, bone/ joint infections
floroquinolone SE
cartilage damage (tendon rupture in elderly and athelets)
long QT
Flagyl is what kind of abx
metronidazole
Flagyl MOA
forms toxic byproducts that cause unstable dna molecules
Flagyl uses
intrabdominal infections, vaginitis, c-diff
Flagyl SE
Peripheral neuropathy
disflurane like effects with etoh, hangoverm dizziness, flushing, ha, chest/ and pain
What abx are administered within 2 hrs of incision
vanc and fluroquinolones