MEDICINES/TOXINS

Question 1

alpha amanitan

Answer 1

toxin produced by poisonous mushroom called death cap. It binds RNA poly III and blocks mRNA synthesis

Question 2

Ritamycin

Answer 2

inhibits transcription like TB

Question 3

Actinomycind

Answer 3

inhibits transcription and used for chemotherapy

Question 4

streptomycin

Answer 4

antibiotic that lands 30s subunit and blocks initiation in prokaryotes

Question 5

chloramphenicol

Answer 5

antibacterial that inhibits peptidyltransferase, cycloheximide in eukaryotes (used in cells producing lots of protein)

Question 6

clindamycin and erthryomycin

Answer 6

inhibits translocase for translation and slides ribosome 3 nucleotides in the 3’ direction

Question 7

diphtheria toxin

Answer 7

inhibits eukaryotic elongation

Question 8

this type of drug blocks the A site in prokaryotes and prevents elongation?

Answer 8

tetracyclines

Question 9

this antibiotic protein synthesis inhibitor leads to premature termination in both pro-and eukaryotes?

Answer 9

puromycin

Question 10

type II topoisomerase in eukaryotes is inhibited by?

Answer 10

Fluroquinones, i.e. ciprofloxacin

Question 11

type I DNA topoisomerase in eukaryotes is inhibited by?

Answer 11

Camptothecins for anti cancer

Question 12

type II DNA topoisomerase in eukaryotes is inhibited by?

Answer 12

Etoposide for anti cancer