medications Flashcards
what is a medicine and what is a drug?
a drug is any substance that alters physiologic function, with the potential for affecting health.
a medicine is a drug that is administered for its potential therapeutic effects.
What is the nurses role in administering medication?
administering the correct med using the right technique and proper precautions
monitoring clients response, knowing incompatibilities and interactions, actions and side effects, know the moral ethical and legal aspects, be familiar with sources of information
have to know how to recognize unsafe and unclear orders and know what to do
help the client administer meds by themselves
what is the nomenclature for drug names
chemical - actual drug composition
generic - ID’s the active ingredient and is given by the manufacturer of the drug
trade - brand name or proprietary names for marketing
official - often the generic name, how the drug is identified in the official publications
how are drugs classified?
effect on body system
chemical composition
clinical indication for its therapeutic action ( antibiotiecs, analgesics )
what is the effect of the body on the drug?
pharmacokinetics
its the movement of the drug through the body in relation to the drug’s absorption, distribution,metabolism, and excretion
what influences absorption of a drug?
route of administration (oral is slowest, injection, then IV)
Lipid solubility (the more lipid soluble the faster)
pH (Acidic drugs in stomach, basic not until small intestines, so they take longer)
Blood Flow (increased with blood flow)
Conditions at the site of administration (the bigger and better the surface, the better the absorption)
Drug dosage ( Larger than normal does given in acute distress will react faster, than a normal maintenance dose)
the goal of a drug is to give a dose that achieves the desired therapeutic effect of the drug… this is called…..
Pharmacotherapeutics
what are the mechanism of drug action (pharmacokinetics)
Absorption
distribution
metabolism
excretion
what factors effect the distribution of a drug?
what are some complications?
blood flow to the tissues, the drugs ability to leave the bloodstream, and the drugs ability to enter the cells
Blood brain barrier, drugs can bind with plasma proteins causing unequal distributions
what is drug metabolism and what is the major site for this occurrence?
what are some other sites that play a role?
(biotransformation), is the change of a drug from its original form to a weaker form.
Liver is primarily responsible (liver function plays a role in this as well as health/disease state)
GI tissues, lungs, kidney, skin
What is excretion?
What organs and structures are responsible?
What are some special requirements and considerations for excretions of drugs?
Once the drugs is broken down to its inactive form then it must be excreted.
Kidneys excrete most drugs
many drugs are excreted through bile in the GI tract
sweat, salivary, mammary glands
Lungs for gaseous excretions
(laws state that drugs have to have details listen concerning the excretion of the drug in elderly pts who may have impaired renal function)
what is the process by which drugs alter cell physiology and affect the body called?
pharmacodynamics
what are adverse effects of drugs?
what are some examples? specifics
Undesirable effects other than the intended therapeutic effects
Allergic - immune system response, evidenced by rash, urticaria, fever, diarrhea, nausea and vomiting
Anaphylactic reaction is the most serious
Drug tolerance - need more to get the desired effect
Toxic effect - when a group of sysptems related to drug therapy can cause permanent damage or death. Can occur from a cumulative effect
Idiosyncratic effect - paradoxical effect is any unusual response to a drug that is manafested by and over response, under response, or opposite response to a drug.
Drug interactions - synergist and antagonistic effects are possibly VERY DANGEROUS FOR ELDERLY ( they see many doctors they dont always bring all their medication, leading to unknown drugs to cause interactions) Interactions can include dietary supplements and herbs.
what are some factors that affect drug action ?
Pregnancy (tetrogenics are drugs that are known to cause developmental defects in the embryo or fetus
Age - older people are sensitive to meds because of physiologic changes during the aging process, may be more susceptible to adverse effects
Weight - kids need smaller doses
gender
religous facters - people may not want/accept or follow orders for medications
Ethnic background and genetics- some ethnic groups obtain a therapeutic response at lower levels than others ( ACE inhibitors for example are less effective in african americans )
Psychological factors - expectations can mess with results, placebo and nocebo effect
Pathology - presence of a disease can effect drug action (liver problems would alter metabolism times and kidney problems would alter excretion times)
Environment - o2 levels, noise, sensory deprivation and overload can all effect positively or negatively
Nutritional state - less proteins in plasma for drugs to bind with mean more active ingredient in blood stream that gives a greater effect
Timing of administration - after meals (some drugs can even react with food), fasting, bed time, etc
What is a therepeutic range?
peak level?
trough level?
half-life?
Onset?
Plateau?
Duration?
the concentration of a drug in the blood serum that produces the desired effect without causing toxicity
highest plasma concentration, measured when absorption is complete
lowest plasma concentration, measured when 30 mins before next administration
the time ti takes for 50% of the substance to be eliminated from the body
time it takes for a med to produce a response
blood serum concentration is reached and maintained
Time medication takes to produce the greatest results
how do hospitals handle meds that a patient has when admitted?
What do they do if the pt is transferred to another clinical service or has surgery?
All meds are discontinued unless ordered otherwise
old perscriptions are stopped and new orders are made at the new facility
What is medication reconciliation?
What is it good for?
When should we be using it ?
process of specifying medications and maintaining a current accurate list of medications the patient is receiving.
It has been shown to decrease pt med errors in transferring pts
Going into and out of a facility
What determines the length of time that an order for narcotics are valid?
State laws
What are the parts of a medication order?
Patients name (FULL NAME)
Date and time order is written
Name of the drug to be administered
Dose
Route
frequency and duration
Signature of person writing the order
When naming a drug to be used, what is the safest way and what do you do if you dont know the drug?
Use the generic name
use the USP-NP
Who decides the frequency in which routine drugs are given?
The nursing service, facility policy, and pharmacy departments