Medication 1 Flashcards
Pharmacokinetics
Absorption, distribution, metabolism and excretion of meds
Pharmacodynamics
Refers to the biologic and therapeutic effects of drugs at target site
Biological half life
Time needed for half of the med to be excreted
Poly pharmacy
The concurrent use of 5 or more meds at the same time
Medications and the elderly
Absorption
Distribution
Metabolism
Excretion
Absorption git
Reduced gastric acidity, alters the way tablets are dissolved
Gastric emptying is slowed there progression of med is slowed
Decreased blood flow in the gut
Absorption skin and intramuscular
Topical faster(skn thinner) Im absorption ( difficult- vasoconstriction, vasodilation)
Metabolism
With advancing age there is a decline in the ability to transform active metabolites to inactive metabolites
Decreased bloood flow in the liver
Decreased liver metabolism
Liver
Decrease hepatic blood flow
Affect serum concentration and volume distribution
Slows down delivery of meds
Distribution
Gradual loss if water, lean meat and more fats
More concentrated in blood and slowly released and distributed
Diminishes volume distribution
Distribution renal
Glomerular filtration rate from early adulthood’s progresses
Diminished renal function affect decrease clearanc e of water in glumerular med
Excretion
With age there is gradual reduction in renal function
Summary absorption
Gastric ph Gastric emptying Gastrointestinal motility Gastric intestinal blood flow Cardiac output circulation
Distribution
Lean muscle
Total body fat total body water
Cardiac output
Metabolism
Enzyme activity
Liver mass
Hepatic blood flow
