mediators of inflammation

Question 1

three stages of inflammatio

Answer 1

acute, subacute, chronic

Question 2

what orchesrates inflammatory response?

Answer 2

mediators

Question 3

pleiotropic

Answer 3

could have more than one response

Question 4

cell derived mediatorys

Answer 4

vasoactive amines
enzymes
prostgladins
cytokines + chemokines
neuropeptides

Question 5

plasma derived mediators

Answer 5

complement system
kinin system
coagulation (clotting) system

Question 6

once mediatory released from the cell

Answer 6

short lived, decay quickly and inactivated or inhibited

Question 7

vasoactive amines

preformed mediators

Answer 7

histamine- vasolidation, vascular permeabilty
(mast cells, basophils, platelts)

serotonin - vasoconctrstion
(platlets)

Question 8

Leukocyte Lysosomal Enzymes

prefroemd mediators

Answer 8

secreted (elastase)- destroy and digest microbes

• destroyed phagocytosed substances
• casues tissue damage

(ex. elastase, collagenase, cathepsin)

Question 9

newly synthesized mediators

AA

Answer 9

eicosanoids

20-carbn
cell membrane phospholipid coponets
mast cells, leukocytes endothelial cells

Question 10

AA mechanism

Answer 10

power point

Question 11

Newly Synthesized : PAF

Answer 11

phospholipid-derived mediator--
* aggregates platlets
vasodialtion
increased permeabilty
chemotaxis

Question 12

PAF mechanism

Answer 12

POwerpoint

Question 13

cytokines

Answer 13

polypeptide products of many cell types

Question 14

abudnatly produced by what?

Answer 14

macrohphage and lymphcoytes

Question 15

action and effects of chemokines

Answer 15

autocrine
paracrine
endocrine

Question 16

major cytokines in acute inflammation

Answer 16

TNF, Il-1, Il-6, chemokines

Question 17

cytokines principle role is?

Answer 17

endothelial activation

Question 18

chronic inflamation cytokines

Answer 18

Il-12 and IFN-y

Question 19

chemikines

Answer 19

chemoattractants for leukocytes

Question 20

function of chemokines

Answer 20

leukocyte recruitment
control cellular organization
activate leukocytes

Question 21

classification

cxc chemokines

Answer 21

Il-8 ==> acute

Question 22

classification cc chemokines

Answer 22

Mcp, mip rantes==>chronic

Question 23

chemokines regulate?

Answer 23

cell trafficking

Question 24

cells migrate toward during chemotaxis to?

Answer 24

toward higher concentraion of chemokines

Question 25

neuropeptides

Answer 25

play a role in
pain, regulate vessel tone
vascular permeabilty

Question 26

Calcitonin Gene Related Peptide

Answer 26

vasodialtion

transmit pain signals

Question 27

what releases ROS

Answer 27

activated pmns and macrophages

Question 28

lysosomal ros

Answer 28

destroy phagocytosied microbes and necrotic cellls

Question 29

secreted ros low levels

Answer 29

^ chemokine, cytokine, adhesion molecule

Question 30

secretied ros high levels

Answer 30

endotheial damage, ^ permeabilty

direct cell injury

Question 31

NO endothieal

Answer 31

eNOS (anti-inflammatory effects)

• vasoliation
• reduced adhesion

Question 32

NO macrophage

Answer 32

iNOS

* cytotoxic

Question 33

plasma protein derived mediators

Hageman Factor

Answer 33

complement
kinin
coagulation

Question 34

how is inflammation turned off

Answer 34

short lived
endogenous
anti inflammator
pharmaceuticals

Question 35

anti-inflammatory cytokines

Answer 35

iL-10-inhibts TNF

IL-2, IL-4 - promote repair

Question 36

endogenous “anti” mediators

Answer 36

antioxidants, lipoxins, protease inhibits, resolvins

Question 37

pharmaceuticals

Answer 37

nsaids (blocks cyclooxygenase (PG production

steroids - block PLA2 (aa formation)

Etanecceot - block action of TNF

antihistamines

Question 38

plaque biofilm reases

Answer 38

toxins, cytokines (LPs, TNF, IL1,8, PGE2)

Question 39

Periodontics

Answer 39

ongoing inflamamtion/infection (CRP, fibrinogen, Il-6)

Question 40

Sysremic disease with oral health disease

Answer 40

cardiovascular disease
diabetes
COPD